在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC38A2 Antibody, HRP conjugated

  • 中文名稱:
    SLC38A2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA847210LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC38A2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Amino acid transporter 2 antibody; Amino acid transporter A2 antibody; ATA2 antibody; KIAA1382 antibody; PRO1068 antibody; Protein 40-9-1 antibody; S38A2_HUMAN antibody; SAT2 antibody; Slc38a2 antibody; SNAT2 antibody; Sodium-coupled neutral amino acid transporter 2 antibody; Solute carrier family 38 member 2 antibody; System A amino acid transporter antibody; System A amino acid transporter 2 antibody; System A transporter 1 antibody; System N amino acid transporter 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sodium-coupled neutral amino acid transporter 2 protein (1-76AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
  • 基因功能參考文獻:
    1. there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function PMID: 27355203
    2. In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport. PMID: 27129276
    3. Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2. PMID: 26608079
    4. Decreased placental mTOR activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR. PMID: 26374858
    5. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2. PMID: 26041779
    6. Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression. PMID: 25653282
    7. SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis. PMID: 23408887
    8. SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows. PMID: 23728383
    9. Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants. PMID: 22028413
    10. findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA PMID: 21930789
    11. Proteomic analysis of TAP-tag purified SNAT2 fusion proteins identified two novel SNAT2-interacting proteins that may potentially function in conjunction with SNAT2 transceptor to regulate signalling pathways influencing protein turnover and cell growth PMID: 21622135
    12. Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. PMID: 20206993
    13. SNAT2 amino acid response element, along with a nearby conserved CAAT box, has enhancer activity and it confers regulated transcription to a heterologous promoter PMID: 14623874
    14. The synthesis of SNAT2 is required for the hypertonic stimulation of system A transport activity. PMID: 15581851
    15. Up-regulation of SNAT2 is essential for the rapid restoration of cell volume after hypertonic stress. PMID: 15922329
    16. Amino acid depletion was associated with an up-regulation of amino acid transport system A activity, largely mediated through an enhancement of SNAT2 expression at both the protein and mRNA level in BeWo cells. PMID: 16125834
    17. deficient in the amino acid response pathway exhibited little or no induction of SNAT2 mRNA PMID: 16445384
    18. The strong expression of Na(+)-coupled neutral amino acid transporter 2 in the somato-dendritic compartment and in non-neuronal elements that are integral parts of the blood-brain and brain-cerebrospinal fluid barrier. PMID: 16616430
    19. SNAT2 expression can be modulated by specific signaling pathways in response to different stresses PMID: 16621798
    20. Results suggest that cortisol may be involved in upregulation of system A (SNAT2)in the placenta to ensure sufficient amino acid supply to the developing fetus. PMID: 16621896
    21. Therefore, we can speculate that such anion-conducting pathways are general features of Na+-transporting systems. PMID: 17237199
    22. Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed PMID: 18697751
    23. Report SNAT2 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    24. analysis of a conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 PMID: 19589777
    25. we have identified a novel regulatory pathway involving increased gene expression of the SNAT2 isoform mediated by a STAT-dependent pathway, which links IL-6 to increased activity of amino acid transporter system A PMID: 19741197

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Amino acid/polyamine transporter 2 family
  • 組織特異性:
    Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein
  • 數據庫鏈接:

    HGNC: 13448

    OMIM: 605180

    KEGG: hsa:54407

    STRING: 9606.ENSP00000256689

    UniGene: Hs.221847



主站蜘蛛池模板: 亚洲午夜私人影院在线观看| 18禁裸体动漫美女无遮挡网站 | 131美女爱做视频国产福利| 精品一区二区久久久久久久网站| 国产精品久久久久9999小说| 亚洲 另类 日韩 制服 无码| 手机看片精品国产福利| 久久久久久久久888| 国产男女性潮高清免费网站| 亚洲伊人久久大香线蕉综合图片| aaa午夜级特黄日本大片| 日本丶国产丶欧美色综合| 内射老妇bbwx0c0ck| av无码中文一区二区三区四区| 国产亚洲另类无码专区| 国产精品成人免费视频网站京东 | 色婷婷综合缴情综免费观看| 亚洲精品一区二区| 制服 丝袜 亚洲 中文 综合| 青青视频免费观看免费 | 久久精品国产99久久久古代| 亚洲狠狠色成人综合网| 日韩免费无砖专区2020狼| 99久久久精品免费观看国产| 国产动作大片中文字幕| 97视频热人人精品免费| 亚洲跨种族黑人xxxxx| 东京热大乱系列无码| 永久黄网站色视频免费直播| 99视频在线精品免费观看6| 日韩美女自卫慰黄网站| 日本无码人妻一区二区色欲| 亚洲精品国产精华液| 国产亚洲精品久久久性色情软件 | 国产成人精品999视频| 风流少妇又紧又爽又丰满| 欧美成人一区二免费视频| 97精品国产久热在线观看| 波多野结衣办公室33分钟| 亚洲日韩av一区二区三区四区| 久久99久久99小草精品免视看 |