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  4. SLC34A3 Antibody

SLC34A3 Antibody

  • 中文名稱：
    SLC34A3兔多克隆抗體
  • 貨號：
    CSB-PA644639
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA644639(SLC34A3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SLC34A3
  • 別名：
    HHRH antibody; Na(+) dependent phosphate cotransporter 2C antibody; Na(+) Pi cotransporter 2C antibody; Na(+)-dependent phosphate cotransporter 2C antibody; Na(+)/Pi cotransporter 2C antibody; NaPi 2c antibody; NaPi-2c antibody; NPT2C antibody; NPT2C_HUMAN antibody; NPTIIC antibody; SLC34A3 antibody; Sodium dependent phosphate transport protein 2C antibody; Sodium inorganic phosphate cotransporter IIC antibody; Sodium phosphate cotransporter 2C antibody; Sodium phosphate transport protein 2C antibody; Sodium-dependent phosphate transport protein 2C antibody; Sodium-phosphate transport protein 2C antibody; Sodium/inorganic phosphate cotransporter IIC antibody; Sodium/inorganic phosphate cotransporter; type IIC antibody; Sodium/phosphate cotransporter 2C antibody; solute carrier family 34 (sodium phosphate) member 3 antibody; solute carrier family 34 (sodium/phosphate contransporter); member 3 antibody; solute carrier family 34 (type II sodium/phosphate contransporter); member 3 antibody; Solute carrier family 34 member 3 antibody; type IIc Na+ Pi cotransporter antibody; Type IIc Na+/Pi cotransporter antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC34A3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.
  • 基因功能參考文獻：
    1. genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3 PMID: 29505567
    2. This is the report of a patient with compound heterozygous mutations of SLC34A3 and normal skeletal features. Biallelic mutations in SLC34A3 can thus be associated with hypercalciuria not accompanied by rickets. PMID: 24924704
    3. Individuals with mutations affecting both SLC34A3 alleles had a significantly increased risk of kidney stone formation or medullary nephrocalcinosis, namely 46% compared with 6% observed in healthy family members carrying only the wild-type allele. PMID: 24700880
    4. this study reports the first cases of hereditary hypophosphatemic rickets with hypercalciuria in Africa and describes a novel causal mutation within the SLC34A3 gene PMID: 23246670
    5. A man with hereditary hypophosphataemic rickets with hypercalciuria & his 3 heterozygous children had a mutation in intron 5 of gene SLC34A3 (NM_080877.2:c[ 448 +5G>A] + [ 448 +5G>A]). PMID: 22806288
    6. Data show 101-bp deletion in intron 9 of the SLC34A3 gene. PMID: 22672866
    7. SLC34A3 mutations (exons and introns) were searched in two previously not reported hereditary hypophosphatemic rickets with hypercalciuria kindreds, which resulted in the identification of three novel mutations. PMID: 22387237
    8. these data suggest that mutations in SLC34A3 in hereditary hypophosphatemic rickets with hypercalciuria result in defective processing and stability PMID: 22159077
    9. Functionally important sites in the predicted first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter (NaPi-IIa) were identified by cysteine scanning mutagenesis (Ehnes et al., 2004). PMID: 15504899
    10. NaP(i)-IIc has a key role in the regulation of phosphate homeostasis. PMID: 16358214
    11. Loss of function of the SLC34A3 protein presumably results in a primary renal tubular defect and is compatible with the hereditary hypophosphatemic rickets with hypercalciuria phenotype. PMID: 16358215
    12. Therefore, understanding the mechanisms that control the apical expression of NaPi-IIa and NaPi-IIc as well as their functional properties is critical to understanding how an organism achieves P i homeostasis. PMID: 16955105
    13. Hereditary hypophosphatemic rickets with hypercalciuria were speculated to be associated with the abnormal functions of phosphate transporter gene type IIc. PMID: 17968493
    14. A novel missense mutation in SLC34A3 causes hereditary hypophosphatemic rickets with hypercalciuria in humans. PMID: 18480181
    15. Novel mutation in the SLC34A3 gene in a patient with an unusual presentation of hereditary hypophosphatemic rickets with hypercalciuria. PMID: 19820004

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  • 相關疾病：
    Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC34A transporter family
  • 數據庫鏈接：

    HGNC: 20305

    OMIM: 241530

    KEGG: hsa:142680

    STRING: 9606.ENSP00000355353

    UniGene: Hs.432442



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