在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC34A2 Antibody

  • 中文名稱:
    SLC34A2兔多克隆抗體
  • 貨號:
    CSB-PA021581LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA021581LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SLC34A2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SLC34A2 antibody; Sodium-dependent phosphate transport protein 2B antibody; Sodium-phosphate transport protein 2B antibody; Na(+)-dependent phosphate cotransporter 2B antibody; NaPi3b antibody; Sodium/phosphate cotransporter 2B antibody; Na(+)/Pi cotransporter 2B antibody; NaPi-2b antibody; Solute carrier family 34 member 2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Sodium-dependent phosphate transport protein 2B protein (574-689AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,SLC34A2 Antibody (CSB-PA021581LA01HU),的標記方式是Non-conjugated。對于SLC34A2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA021581LB01HU SLC34A2 Antibody, HRP conjugated ELISA
    FITC CSB-PA021581LC01HU SLC34A2 Antibody, FITC conjugated
    Biotin CSB-PA021581LD01HU SLC34A2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
  • 基因功能參考文獻:
    1. The upstream breakpoint lies in the same region as the breakpoint of a fused gene SLC34A2-ROS1, which encodes a constitutive kinase in the lung cancer cell line HCC78 and nonsmall-cell lung cancer (NSCLC), suggesting that the deletion in this family is a hot spot for recombination, not only in cancer samples with somatic mutation, but also in PAM patients with germline genetic defects of SLC34A2. PMID: 30262706
    2. SLC34A2 plays a crucial promoting role in colorectal cancer development. PMID: 29653487
    3. Studied expression of solute carrier family 34 member 2 (SLC34A2/NaPi2b) in epithelial ovarian cancer using monoclonal antibody MX35 and immunohistochemistry. Different staining intensities were observed in different grades of epithelial ovarian cancer. PMID: 28464843
    4. Low SLC34A2 expression is associated with non-small cell lung cancer. PMID: 26910912
    5. SLC34A2 has an important role in promoting proliferation and tumorigenicity of BC. PMID: 28151475
    6. SLC34A2 was down-regulated in osteosarcoma patients.SLC34A2 interacted with PTEN, and decreased the phosphorylation of PI3K and AKT, which inactivated the PI3K/AKT signaling pathway. PMID: 28777670
    7. High expression of SLC34A2 was identified in about 2/3 patients and correlated with significantly better patient's overall survival. Epidermal growth factor receptor mutations were detected in about 53% of patients with no statistically significant difference to patient's overall survival. Anaplastic lymphoma kinase rearrangement was found in 8 out of 175 patients, harboring this abnormality leads to shorter overall survi PMID: 28720066
    8. we elucidated that miR-939 exerted its function mainly through inhibiting SLC34A2/Raf/MEK/ERK pathway, which is activated in GC. Multivariate analysis identified miR-939, SLC34A2, and their combination as independent indicators for poor prognosis and tumor recurrence in GC patients. PMID: 28114937
    9. a novel role of SLC34A2 inbreast cancer stem cells (BCSCs) state regulation and establishes a rationale for targeting the SLC34A2/PI3K/AKT/SOX2 signaling pathway for breast cancer therapy. PMID: 28381172
    10. Knockdown of SLC34A2 inhibits proliferation. PMID: 28281971
    11. Our work sheds new light on the nature of the state of lung cancer stem cell-like cells and the role of SLC34A2 in the tumorigenicity of these cells PMID: 26846105
    12. our data indicated that SLC34A2 could exert significantly suppressive effects on tumorigenesis and progression of NSCLC. SLC34A2 might provide new insights for further understanding the early pathogenesis of human non-small cell lung cancer PMID: 26156586
    13. SLC34A2 might be associated with the initiation and progression of lung adenocarcinoma PMID: 25017204
    14. Data indicate that humanized monoclonal antibody Rebmab200 and murine monoclonal antibody MX35 monoclonal antibodies had similar specificity for sodium phosphate transporter NaPi2b. PMID: 23936189
    15. investigation revealed that the c.910A > T mutation in the SCL34A2 gene was responsible for pulmonary alveolar microlithiasis (PAM) patients in China PMID: 23164546
    16. identified 2 cases of pulmonary alveolar microlithiasis(PAM) with new mutations of SLC34A2 gene; identified the NaPi-IIb in a aortic valve; hypothesize that mutations in SLC34A2 may play a role in development of aortic valve calcification and arteriosclerosis PMID: 22336687
    17. a comprehensive analysis indicates that SCL34A2 is the only gene of the several phosphate transporters genes whose expression differentiates normal from carcinoma samples, suggesting it might exert a major role in ovarian carcinomas. PMID: 22553815
    18. The performed study revealed that SLC34A2 gene exhibited the most distinct change in expression and may become a molecular marker of papillary thyroid cancer PMID: 17091453
    19. study provides the data on the pattern of NaPi2b expression and cellular localization in breast, lung and ovarian cancers PMID: 21956469
    20. Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis. PMID: 21716206
    21. There was a significantly increased gene expression of SLC34A2 (normal tissues: 6.71+/-0.77; tumour tissues: 10.29+/-0.80) among breast cancer tissues compared with normal tissues. PMID: 21036732
    22. In human lung alveolar epithelial cells, the content of calcium and phosphate in cell supernatant decreased with increased amount of SLC34A2 mRNA. PMID: 19134407
    23. study describes mutations in SLC34A 2 gene in an inbred Turkish family with three siblings diagnosed with pulmonary alveolar microlithiasis(PAM); findings suggest that impaired activity of the SLC34A2 gene may be responsible for familial PAM PMID: 20046000
    24. A novel mutation in exon 8 of the SLC34A2 gene were associated with pulmonary alveolar microlithiasis in Chinese pedigree. PMID: 20017296
    25. The current study was performed to characterize the minimal promoter region and transcriptional factor(s) necessary to activate gene expression of NaPi-IIb in human intestinal cells. PMID: 15458926
    26. Study identified a pulmonary alveolar microlithiasis locus by homozygosity mapping to 4p15, then identified, by a candidate-gene approach, the gene responsible for the disease as SLC34A2, which is involved in phosphate homeostasis in several organs. PMID: 16960801
    27. Mutations in the SLC34A2 gene that abolish normal gene function cause pulmonary alveolar microlithiasis. PMID: 17095743
    28. The monoclonal antibodies were shown to recognize specifically transiently overexpressed and endogenous NaPi2b in commonly used immunoassays. PMID: 18724815
    29. SLC34A2 is associated with sodium-lithium countertransport activity and blood pressure PMID: 19119262
    30. The gene responsible for PAM, SLC34A2, has been identified. It encodes a type IIb sodium-dependent phosphate transporter, the function of which provides an insight into the pathogenesis of this disease. PMID: 19617834

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Pulmonary alveolar microlithiasis (PALM)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC34A transporter family
  • 組織特異性:
    Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11020

    OMIM: 265100

    KEGG: hsa:10568

    STRING: 9606.ENSP00000371483

    UniGene: Hs.479372



主站蜘蛛池模板: 欧美日韩国产免费一区二区三区| 亚洲毛片αv无线播放一区| 国产女主播喷水视频在线观看| 亚洲乱码国产乱码精品精大量| 成人av在线一区二区三区| 亚 洲 成 人 网站在线观看| 久久www成人免费直播| 精品久久久无码中文字幕 | 久久久久人妻一区精品色欧美| www国产亚洲精品久久| 国产在线第一区二区三区| 性暴力欧美猛交在线播放| 成熟丰满熟妇高潮xxxxx| 18禁成年免费无码国产| 亚洲男人综合久久综合天堂| 欧美亚洲日本高清不卡| 日韩精品一区二区在线观看| 熟女人妻aⅴ一区二区三区麻豆| 欧美特黄特色三级视频在线观看| 好爽好黄的视频| 先锋影音最新色资源站| 无遮挡午夜男女xx00动态| 日韩精品无码去免费专区| 国产精品亚洲综合色区韩国| 久久久久久人妻一区精品| 国产成人av在线播放影院| 欧美天天综合色影久久精品| 亚洲精品成人无码中文毛片不卡 | 色狠狠久久av五月综合| 久久综合久久88中字幕文| 国产精品亚洲a∨天堂不卡| 99久久国产综合精品麻豆| 青青草国产精品日韩欧美| 老司机免费的精品视频| 欧美性受xxxxzooz乱毛| 日日碰狠狠添天天爽| 精品国产一区二区三区四区在线看| 青青久久成人免费影院| 中文乱码免费一区二区三区| 国产亚洲色婷婷久久99精品| 成人免费毛片内射美女app|