在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC30A10 Antibody, FITC conjugated

  • 中文名稱:
    SLC30A10兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA747695LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC30A10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC30A10
  • 別名:
    SLC30A10; ZNT10; ZNT8; Zinc transporter 10; ZnT-10; Manganese transporter SLC30A10; Solute carrier family 30 member 10
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Zinc transporter 10 protein (58-278AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells.
  • 基因功能參考文獻:
    1. Structural homology analysis provide evidence that L349P mutation severe structural changes of ZnT-10 in its CTD domain resulting in abnormal reduced function. PMID: 27550551
    2. SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 pathway. PMID: 28688763
    3. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 or restoring the Mn-induced trafficking of ATP2C1 can reduce Mn accumulation, providing a possible target for treating HMDPC. PMID: 28692648
    4. results indicate that residues in the transmembrane and C-terminal domains together confer optimal manganese transport capability to SLC30A10 and suggest that the mechanism of ion coordination in the transmembrane domain of SLC30A10 may be substantially different from that in YiiP/other SLC30 proteins. PMID: 27307044
    5. allele was also associated with increased sway velocity (15%, P = .033; adjusted for age and sex) and reduced SLC30A10 expression PMID: 26628504
    6. We describe early disease manifestations (including videos) in 5 previously unreported Indian children, carrying novel homozygous SLC30A10 mutation PMID: 25778823
    7. SLC30A10 is a cell surface-localized manganese efflux transporter that reduces manganese levels and protects against manganese toxicity. PMID: 25319704
    8. These results suggest that both the up-regulation of ZIP14 and the down-regulation of ZnT10 by IL-6 might have enhanced the accumulation of manganese in SH-SY5Y cells. PMID: 24576911
    9. a case of inherited manganism caused by SLC30A10 mutation is presented PMID: 23369405
    10. ZnT10 is significantly decreased in the frontal cortex in Alzheimer's disease. PMID: 23741496
    11. This review will address Mn transport proteins, the newly discovered SLC30A10 mutations and their implications to Parkinsonism and Mn regulation. PMID: 23357421
    12. The study demonstrates down-regulation by Zn of ZnT10 mRNA levels in cultured intestinal and neuroblastoma cell lines and demonstrate reduced transcription from the ZnT10 promoter at an elevated extracellular Zn concentration. PMID: 22706290
    13. SLC30A10 mutations cause a treatable recessive disease with pleomorphic phenotype, and provide compelling evidence that SLC30A10 plays a pivotal role in manganese transport. PMID: 22341971
    14. This work has confirmed that SLC30A10 functions as a Mn transporter in humans that, when defective, causes Mn accumulation in liver and brain. PMID: 22341972
    15. identified the full-length sequences of SLC30A10, extending the SLC30 family to ten members; used an expressed sequence tag (EST) data mining strategy to determine the pattern of ZnT genes expression in tissues PMID: 15154973

    顯示更多

    收起更多

  • 相關疾病:
    Hypermanganesemia with dystonia 1 (HMNDYT1)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Recycling endosome. Early endosome.
  • 蛋白家族:
    Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
  • 組織特異性:
    Specifically expressed in fetal liver and fetal brain. Expressed in adult tissues with relative levels small intestine > liver > testes > brain > ovary > colon > cervix > prostate > placenta.
  • 數據庫鏈接:

    HGNC: 25355

    OMIM: 611146

    KEGG: hsa:55532

    STRING: 9606.ENSP00000355893

    UniGene: Hs.284450



主站蜘蛛池模板: 人人妻碰人人免费| 一二三区乱码不卡手机版| 日韩av无码社区一区二区三区| 日本少妇三级hd激情在线观看| 国产精品视频免费一区二区| 国产精品久久久久9999爆乳 | 久久久欧美国产精品人妻噜噜| 老司机深夜18禁污污网站| 精品免费国偷自产在线视频| 日本极品少妇videossexhd| 欧美成人午夜免费全部完| 永久免费的啪啪网站免费观看 | 波多野结衣在线观看一码| 国产精品18久久久| 国产成人亚洲精品无码车a | 成年午夜无码av片在线观看| 久久久久无码精品国产不卡| 久久久久77777人人人人人| 免费乱理伦片在线观看八戒| 国产 亚洲 制服 无码 中文| 男女吃奶做爰猛烈紧视频| 国产成人92精品午夜福利| 人妻无码av中文系列久| 无码熟妇人妻av| 成人伊人亚洲人综合网站| 欧美成人精品午夜免费影视| 大肉大捧一进一出好爽视频mba| 中文字幕在线亚洲精品| 国产在线视频天天综合网| 伊人久久精品亚洲午夜| 中国丰满熟妇xxxx性| 不卡无码av一区二区三区| 亚洲精品午夜一区人人爽| 亚洲国产精品一区二区www| 国产精品无码一区二区在线| 亚洲乱码卡一卡二卡| 久久99精品久久久久久不卡| 熟妇女人妻丰满少妇中文字幕| 一区三区不卡高清影视| 久久好在线视频| 国产亚洲精品无码成人|