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  4. SLC2A12 Antibody

SLC2A12 Antibody

  • 中文名稱：
    SLC2A12兔多克隆抗體
  • 貨號：
    CSB-PA067005
  • 規格：
    ￥1100
  • 圖片：
    • The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA067005 at dilution 1/30. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SLC2A12
  • 別名：
    Glucose transporter type 12 antibody; GLUT 12 antibody; GLUT-12 antibody; GLUT12 antibody; GLUT8 antibody; GTR12_HUMAN antibody; SLC2A12 antibody; Solute carrier family 2 (facilitated glucose transporter) member 12 antibody; Solute carrier family 2 facilitated glucose transporter member 12 antibody; Solute carrier family 2 member 12 antibody; Solute carrier family 2, facilitated glucose transporter member 12 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC2A12
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Insulin-independent facilitative glucose transporter.
  • 基因功能參考文獻：
    1. GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations. PMID: 29187448
    2. GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties. PMID: 25855082
    3. findings show the level of expression of GLUT12 was significantly higher in Alzheimer's disease compare to aged controls PMID: 24820014
    4. Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 PMID: 23396969
    5. Embedded in microvillous (maternal-facing) and basal (fetal-facing) membranes of syncytiotrophoblast, main placental barrier layer. (review) PMID: 12583599
    6. Glucose transport properties and hexose affinities of GLUT12. PMID: 12914765
    7. GLUT12 protein was localized to the apical membrane of human and rat distal tubules and collecting ducts. Levels of both GLUT1 and GLUT12 are elevated in animal models of hypertension and diabetic nephropathy. PMID: 16091581
    8. GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers PMID: 16803853
    9. Translocation of GLUT12 in cultured myoblasts was dependent on activation of PI3-K. PMID: 19549745

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 組織特異性：
    Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.
  • 數據庫鏈接：

    HGNC: 18067

    OMIM: 610372

    KEGG: hsa:154091

    STRING: 9606.ENSP00000275230

    UniGene: Hs.486508



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