在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC28A3 Antibody, Biotin conjugated

  • 中文名稱:
    SLC28A3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA884504LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC28A3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC28A3
  • 別名:
    SLC28A3 antibody; CNT3Solute carrier family 28 member 3 antibody; Concentrative Na(+)-nucleoside cotransporter 3 antibody; CNT 3 antibody; hCNT3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier family 28 member 3 protein (1-102AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.
  • 基因功能參考文獻:
    1. De novo structure prediction of three N-terminal transmembrane helices of the human concentrative nucleoside transporter 3 (hCNT3) homotrimer belonging to the solute carrier 28 family of transporters (SLC28) using Rosetta program and its Broker protocol. PMID: 28774292
    2. CYR61 negatively regulates the nucleoside transporters hENT1 and hCNT3 in pancreatic ductal adenocarcinoma. PMID: 27604902
    3. Data suggest that CNT3 forms a homotrimer in solution and membrane-bound inside cells; the quaternary structure creates an aqueous basin that significantly shortens the substrate translocation distance. PMID: 28661652
    4. results that validate the newly developed structural homology model of CNT membrane architecture for human CNTs, revealed extended conformationally mobile regions within transport-domain TMs, identified pore-lining residues of functional importance, and provided evidence of an emerging novel elevator-type mechanism of transporter function. PMID: 28385889
    5. Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as good candidates for modulatory genes in the auditory system. [meta-analysis] PMID: 26188009
    6. The co-expression of galectin-4 and CNT3 proteins is not impaired in inflamed colon from patients with Crohn's disease, thereby anticipating the integrity of this system for drug targeting. PMID: 26481311
    7. Results show that high CNT3 expression level is associated with overall favorable outcomes and is predictive of clinical outcomes in acute myeloid leukemia patients with t(8;21). PMID: 25955569
    8. The presence of homozygous major allele for SLC28A3 (CC genotype) were each associated with an almost two-fold increase in the formation clearance of dFdCTP. PMID: 24300978
    9. Genetic polymorphisms in SLC28A3, SLC29A1 and RRM1 can influence the clinical outcome of metastatic breast cancer patients treated with paclitaxel-gemcitabine chemotherapy. PMID: 24361227
    10. association between ribavirin (RBV) serum levels and SLC28A2 rs11854484 genotype, as well as the replicated association of ITPA and SLC28A3 genetic polymorphisms with RBV-induced anemia and treatment response PMID: 23195617
    11. Data show that ENT1, ENT2, ENT4 and CNT3 protein was detected on ovarian carcinoma cells in all effusions, with expression observed in 1-95% of tumor cells. PMID: 21822668
    12. A genetic variant in SCL28A3 coding for the concentrative nucleoside transporter 3 protects patients with chronic hepatitis C against hemolytic anemia without affecting sustained virological response in hepatitis C virus genotype 1. PMID: 21346688
    13. Acidic and hydrophobic motifs in the N terminus tail of the hCNT3 control ER export and cell surface expression levels in nonpolarized cells, whereas a putative beta-turn domain contributes to hCNT3 polarized surface expression in epithelial cells. PMID: 20643903
    14. H+ drives uridine and adenosine transport by hCNT3 with lower affinity but higher maximal transport rate than Na+. PMID: 20495821
    15. TGF-beta1 acts through activation of ERK1/2 and the small GTPase RhoA to promote plasma membrane trafficking of the hCNT3 protein. PMID: 20172853
    16. hCNT3 gene is evolutionarily conserved with hCNT1 and hCNT2. Physiologically, hCNT3 is a glycoprotein, which transports purine and pyrimidine nucleosides in a Na-dependent manner with high affinities. PMID: 14504928
    17. genetic analysis and functional characterization of CNT3 variants suggest that this transporter does not tolerate nonsynonymous changes and is important for human fitness PMID: 15738947
    18. examination of single nucleotide polymorphisms in the coding regions of the hCNT3 gene PMID: 15861042
    19. hCNT3 possesses two Na+-binding sites, only one of which is shared by H+ PMID: 15870078
    20. The effects of cysteine substitution mutants spanning transmembrane domains 11-13 on the transport activity of CNT3 expressed in S. cerevisiae are reported. PMID: 16271041
    21. Minimal features required for human CNT3 transport are two hydrogen bond acceptors at 3'-OH and 5'-O and the hydrophobic center occupied by the base ring. PMID: 16446384
    22. transcripts for CNT3 protein in human kidneys and in cultured proximal tubule cells suggest involvement of CNT3 in renal handling of nucleosides and nucleoside drugs PMID: 17409283
    23. CNT3 was inserted into the apical membrane, thus generating, a transepithelial flux of both nucleosides and nucleoside-derived drugs. PMID: 17412768
    24. hCNT2 shares common cation specificity and coupling characteristics with hCNT1, which differ markedly from those of hCNT3. PMID: 17453413
    25. This study shows that adenosine elimination on human airway epithelia is mediated by ADA1, CNT2, and CNT3, which constitute important regulators of adenosine-mediated inflammation. PMID: 17696452
    26. These data suggest that selected genes of the SLC28 and SLC29 families are not only targets of HIV-1 infection, but might also contribute to the development of adipose tissue alterations leading to lipodystrophy. PMID: 17926640
    27. A polymorphic variant of the human concentrative nucleoside transporter, CNT3, is found that severely affects its functionality. PMID: 17993510
    28. identified a C-terminal intramembranous cysteine residue of hCNT3 (Cys-561) that reversibly binds the hydrophilic thiol-reactive reagent p-chloromercuribenzene sulfonate (PCMBS) PMID: 18199742
    29. a pivotal functional role for Cys-561 in Na+- as well as H+-coupled modes of hCNT3 nucleoside transport PMID: 18621735
    30. The isolation and charcterization of an alternatively spliced SLC28A3-related mRNA is reported. PMID: 18827020
    31. This evidence suggested that apical CNT3 and basolateral ENT2 are involved in proximal tubular reabsorption of adenosine and some nucleoside drugs and that apical ENT1 is involved in proximal tubular secretion of 2'-deoxyadenosine. PMID: 19297449
    32. Pancreatic adenocarcinoma patients with a high expression of hENT1 and hCNT3 immunostaining have a significantly longer survival after adjuvant gemcitabine-based chemoradiation PMID: 19318496
    33. identified residues of functional importance and with a revised 15-TM membrane architecture, suggest a novel membrane-associated topology for a region of the protein (TM 11A) that includes the highly conserved CNT family motif (G/A)XKX(3)NEFVA(Y/M/F) PMID: 19380585
    34. identified two conserved pore-lining glutamate residues (Glu-343 and Glu-519) with essential roles in CNT3 Na(+)/nucleoside and H(+)/nucleoside cotransport PMID: 19380587

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
  • 組織特異性:
    Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.
  • 數據庫鏈接:

    HGNC: 16484

    OMIM: 608269

    KEGG: hsa:64078

    STRING: 9606.ENSP00000365413

    UniGene: Hs.535966



主站蜘蛛池模板: 我的性奴的肉玩具1一17心奴| 色欲av伊人久久大香线蕉影院| 真实的国产乱xxxx| 草草影院精品一区二区三区| 国产人妻精品一区二区三区| 亚洲精品国产精品乱码不卡√| 色欲av久久综合人妻无码| 小箩莉末发育娇小性色xxxx| 日日摸日日碰人妻无码| 韩国主播av福利一区二区| 好日子在线观看视频大全免费动漫| 精品无人区卡一卡二卡三乱码| 伊伊人成亚洲综合人网7777| 精品国产日韩亚洲一区| 国产亚洲精品福利在线无卡一| 国产精品成人免费一区久久羞羞 | 久久免费午夜福利院| 亚洲啪av永久无码精品放毛片| 亚洲人成网站18禁止一区| 亚洲精品无码久久久久av老牛| 久久熟妇人妻午夜寂寞影院| 亚洲欧美日韩在线不卡| 人人妻人人澡人人爽精品日本| 人妻少妇偷人无码视频| 熟睡中被义子侵犯在线播放| 久久精品女人天堂av| 欧美另类videosbestsex日本| 国产热re99久久6国产精品首页| 2021国产精品成人免费视频| 国产精品美女久久久久久2021| 韩国精品无码少妇在线观看| 欧美高清freexxxx性| 少妇太爽了在线观看免费视频 | 高中国产开嫩苞实拍视频在线观看| 国内精品伊人久久久久影院对白| 熟妇人妻午夜寂寞影院| 99精品久久99久久久久| 少妇粉嫩小泬白浆流出| www成人国产高清内射| 国产很色很黄很大爽的视频| 亚洲成a人v电影在线观看|