在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SLC28A2 Antibody

SLC28A2 Antibody

  • 中文名稱：
    SLC28A2兔多克隆抗體
  • 貨號：
    CSB-PA001737
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 3T3 cells using CNT2 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using CNT2 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SLC28A2
  • 別名：
    SLC28A2 antibody; CNT2 antibody; Sodium/nucleoside cotransporter 2 antibody; Concentrative nucleoside transporter 2 antibody; CNT 2 antibody; hCNT2 antibody; Na(+)/nucleoside cotransporter 2 antibody; Sodium-coupled nucleoside transporter 2 antibody; Sodium/purine nucleoside co-transporter antibody; SPNT antibody; Solute carrier family 28 member 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CNT2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
  • 基因功能參考文獻(xiàn)：
    1. results that validate the newly developed structural homology model of CNT membrane architecture for human CNTs, revealed extended conformationally mobile regions within transport-domain TMs, identified pore-lining residues of functional importance, and provided evidence of an emerging novel elevator-type mechanism of transporter function. PMID: 28385889
    2. association between ribavirin (RBV) serum levels and SLC28A2 rs11854484 genotype, as well as the replicated association of ITPA and SLC28A3 genetic polymorphisms with RBV-induced anemia and treatment response PMID: 23195617
    3. genetic association studies in population in Italy: Data suggest that 3 SNPs (SLC28A2 rs11854484; IL28B, rs8099917; CYP27B1, rs4646536) are associated with pharmacokinetics of ribavirin and thus, sustained virologic response in hepatitis C patients. PMID: 23149444
    4. These findings support the theory that CNT2 plays roles other than salvage and establishes links with energy metabolism. PMID: 20506327
    5. there are notable species differences in the specificity of SPNT for synthetic nucleoside analogs. PMID: 12110519
    6. Characterization of sodium-dependent nucleoside transporter hCNT2 cloned from duodenum. PMID: 12893280
    7. Human nucleoside transporters involved in cellular uptake of Bbenzamide riboside and tiazofurin and their role in cytotoxicity. PMID: 15486050
    8. analysis of polymorphisms in the human concentrative nucleoside transporter, CNT2 PMID: 15861032
    9. Results identify the critical domains and amino acid residues that contribute to the observed difference in specificity between concentrative nucleoside transporter (CNT)2 orthologs. PMID: 16840788
    10. HNF4alpha is a major determinant of SLC28A1 expression, whereas C/EBPalpha and HNF3gamma modulate SLC28A2 gene expression. PMID: 17187757
    11. hCNT2 shares common cation specificity and coupling characteristics with hCNT1, which differ markedly from those of hCNT3. PMID: 17453413
    12. This study shows that adenosine elimination on human airway epithelia is mediated by ADA1, CNT2, and CNT3, which constitute important regulators of adenosine-mediated inflammation. PMID: 17696452
    13. Five novel nonsynonymous variants (L12R, R142H, E172D, E385K, M612T) expressed in U-251 cells revealed that all except E385K can uptake various substrates of CNT2: inosine, ribavirin and uridine. PMID: 17700367
    14. These data suggest that selected genes of the SLC28 and SLC29 families are not only targets of HIV-1 infection, but might also contribute to the development of adipose tissue alterations leading to lipodystrophy. PMID: 17926640
    15. Report expression and hepatobiliary transport characteristics of CNT2 in sandwich-cultured human hepatocytes. PMID: 18635603
    16. Single nucleotide polymorphisms of this protein may play a role in variation in the pharmacokinetics and pharmacological effects of nucleoside analogs. PMID: 19098160
    17. Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20028759

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
  • 組織特異性：
    Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11002

    OMIM: 606208

    KEGG: hsa:9153

    STRING: 9606.ENSP00000315006

    UniGene: Hs.367833



主站蜘蛛池模板： 日韩av一国产av一中文字慕| 人妻少妇久久中文字幕| 免费观看黄网站在线播放| 亚洲亚洲人成综合网络| 午夜无码乱码在线观看| 女同性av片在线观看免费网站| 国产成人精品无码一区二区三区| 亚洲卡一卡二乱码新区仙踪| 337p大胆啪啪私拍人体| 亚无码乱人伦一区二区| 精品第一国产综合精品蜜芽| 欧美精品18videosex性欧| 亚洲国产精品无码中文字2022| 中文字幕日本六区小电影| 国产麻豆乱子伦午夜视频观看| 日本强伦姧人妻久久影片| 五月丁香综合激情六月久久| 麻豆av一区二区天美传媒| 国产喷水1区2区3区咪咪爱av| 久久精品国产只有精品66| 特黄熟妇丰满人妻无码| 久久久无码一区二区三区| 国产在线一卡2卡三卡4卡免费| 丰满少妇aaaaaa爰片毛片| 131mm少妇做爰视频| 国产品无码一区二区三区在线| 日本高清熟妇老熟妇| 波多野结av在线无码中文| 亚洲一区二区三区| 中文字幕人成乱码熟女app| 综合激情亚洲丁香社区| 亚洲成av人片天堂网站| 麻豆高清免费国产一区| 国产97超碰人人做人人爱| 亚洲成aⅴ人最新无码| 少妇的肉体在线观看| 国产成人精品日本亚洲77上位| 国产乱子伦三级在线播放| 少妇久久久久久人妻无码| 国产精品久久无码一区| 毛片tv网站无套内射tv网站|