在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC27A4 Antibody

  • 中文名稱:
    SLC27A4兔多克隆抗體
  • 貨號:
    CSB-PA193776
  • 規格:
    ¥2024
  • 圖片:
    • Immunofluorescence analysis of A549 cells, using SLC27A4 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC27A4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SLC27A4; ACSVL4; FATP4; Long-chain fatty acid transport protein 4; FATP-4; Fatty acid transport protein 4; Arachidonate--CoA ligase; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4; ACSVL4
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human SLC27A4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.
  • 基因功能參考文獻:
    1. SLC27A4 gene mutation is responsible in the diagnosis of ichthyosis prematurity syndrome in a premature infant. PMID: 26341232
    2. expand the mutational repertory of FATP4 with three undescribed pathogenic mutations in two families PMID: 27168232
    3. The results have interesting implications that SLC27A4/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application. PMID: 26662804
    4. no association between placental expression and maternal body mass index PMID: 27016784
    5. we resequenced the SLC27A3 and SLC27A4 genes using 267 autism spectrum disorders(ASD) patient and 1140 control samples and detected 47 and 30 variants for the SLC27A3 and SLC27A4, revealing that they are highly polymorphic with multiple rare variants. PMID: 26548558
    6. We describe two siblings with ichthyosis prematurity syndrome and report a recurrent homozygous mutation (c.1430T>A) that is predicted to lead to a p.Val477Asp substitution in fatty acid transport protein 4. PMID: 24889544
    7. the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
    8. the clinical implications of defects in these transporters and relevant animal models, including the FATP4 animal models and ichthyosis prematurity syndrome, a congenital ichthyosis caused by FATP4 deficiency. [review] PMID: 24120574
    9. FATP4, ichthyin and TGM1 interact in lipid processing essential for maintaining the epidermal barrier function PMID: 23290633
    10. FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum PMID: 23271751
    11. FATP1 and FATP4 proteins perform different functional roles in handling long chain fatty acids in skeletal muscle PMID: 22235293
    12. even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. PMID: 22028793
    13. Mutation in FATP4 in a patient with self-healing congenital verruciform hyperkeratosis.( PMID: 20815031
    14. findings propose fatty acid transport protein 4 as a candidate gene for the insulin resistance syndrome PMID: 14715877
    15. intra-pair correlations revealed that FATP4 expression was significantly up-regulated in acquired obesity." PMID: 15168018
    16. Data suggest that endogenous FATP4 does not function to translocate fatty acids across the plasma membrane, but functions more as a very long-chain acyl-CoA synthetase. PMID: 17901542
    17. Mutations in FATP4 gene cause the ichthyosis prematurity syndrome. PMID: 19631310

    顯示更多

    收起更多

  • 相關疾病:
    Ichthyosis prematurity syndrome (IPS)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    ATP-dependent AMP-binding enzyme family
  • 組織特異性:
    Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tiss
  • 數據庫鏈接:

    HGNC: 10998

    OMIM: 604194

    KEGG: hsa:10999

    STRING: 9606.ENSP00000300456

    UniGene: Hs.656699



主站蜘蛛池模板: 色妞色视频一区二区三区四区 | 免费中文熟妇在线影片| 十八禁视频网站在线观看| 免费无码久久成人影片 | 国产精品成人永久在线| 99精品国产在热久久无毒| 国产免费一区二区三区在线观看| 精品国产偷窥一区二区| 无码熟妇人妻av在线影片最多| 少妇性荡欲视频| 国产精品扒开腿做爽爽爽a片唱戏| 苍井空张开腿实干12次| 久久精品2021国产| 又黄又湿啪啪响18禁| 无码乱人伦一区二区亚洲| 亚洲精品一区二区三区不卡| 国产白嫩漂亮美女在线观看 | 国产成人精品优优av| 免费视频爱爱太爽了| 无码日韩人妻av一区免费| 亚洲小说春色综合另类| 免费人成视频在线| 丁香婷婷无码不卡在线| 亚洲国产成人无码精品| 亚洲精华国产精华精华液网站| 怡春院国产精品视频| 777米奇影院狠狠色| 特级毛片在线大全免费播放| 国产99久久久久久免费看| 伊人精品成人久久综合| 欧美精品一国产成人综合久久| 老太婆性杂交欧美肥老太| 国产免费爽爽视频| 天天影视性色香欲综合网| 亚洲爆乳无码专区| 性欧美牲交在线视频| 正在播放熟妇群老熟妇456| 亚洲国产精品第一区二区| 成人免费无遮挡无码黄漫视频| 在线|国产精品女主播阳台| 久久久亚洲精品成人|