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  4. SLC25A14 Antibody, HRP conjugated

SLC25A14 Antibody, HRP conjugated

  • 中文名稱：
    SLC25A14兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA021480LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC25A14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC25A14
  • 別名：
    SLC25A14; BMCP1; UCP5; UNQ791/PRO1682; Brain mitochondrial carrier protein 1; BMCP-1; Mitochondrial uncoupling protein 5; UCP 5; Solute carrier family 25 member 14
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Brain mitochondrial carrier protein 1 protein (55-111AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Participates in the mitochondrial proton leak measured in brain mitochondria.
  • 基因功能參考文獻：
    1. Increased expression of cerebral UCP5 and UCP4 is observed in a model of high altitude hypoxia and mitochondrial oxidative phosphorylation deficiency. PMID: 23266757
    2. Neuronal UCP5 exhibits transmembrane chloride transport activity. PMID: 22524567
    3. observed significant associations between genetic variants in the SIRT6 and UCP5 genes and atherosclerotic plaque PMID: 22087257
    4. The enhanced level of UCP5 is associated to mitochondrial dysfunction in colonic cells. PMID: 19910678
    5. expressed in skeletal muscle as three different isoforms; expression level of UCP5SI positively correlated with resting metabolic rate and lipid oxidation rate during a euglycemic clamp with infusion of insulin at a physiologic concentration PMID: 12051969
    6. UCP5 might be physiologically important in the pathology of oxidative stress-induced neurodegeneration PMID: 16941493
    7. The brain may respond to neuroprotection through the increased expression of UCP5 under ischemic conditions. PMID: 18018477

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  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性：
    Mainly expressed in brain. Some expression in testis and pituitary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10984

    OMIM: 300242

    KEGG: hsa:9016

    STRING: 9606.ENSP00000218197

    UniGene: Hs.194686



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