在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC23A1 Antibody, HRP conjugated

  • 中文名稱:
    SLC23A1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA887038LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC23A1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC23A1
  • 別名:
    hSVCT1 antibody; Na(+)/L-ascorbic acid transporter 1 antibody; S23A1_HUMAN antibody; Slc23a1 antibody; Sodium-dependent vitamin C transporter 1 antibody; solute carrier family 23 (nucleobase transporters); member 1 antibody; Solute carrier family 23 member 1 antibody; SVCT1 antibody; Yolk sac permease-like molecule 3 antibody; YSPL3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier family 23 member 1 protein (173-259AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
  • 基因功能參考文獻:
    1. consensus site for HNF1 that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity PMID: 25933589
    2. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis. PMID: 24708273
    3. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS] PMID: 25527764
    4. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells. PMID: 22990596
    5. A genetic variant in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort. PMID: 24284447
    6. SVCT1 directly interacts with GRHPR. PMID: 23599041
    7. These findings show a role for Rab8a in the physiological function of SVCT1 in intestinal epithelia. PMID: 23014846
    8. A genetic variant (rs33972313) in the SLC23A1 vitamin C active transporter locus was identified that is reliably associated with circulating concentrations of L-ascorbic acid in the general population. PMID: 20519558
    9. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20519558
    10. SVCT1 is the transporter that allows vectorial uptake of ascorbic acid in differentiated CaCo-2 cells PMID: 12381735
    11. Results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity. PMID: 15084584
    12. Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth. PMID: 16357110
    13. C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production PMID: 17008880
    14. We present a transport model for SVCT1 that will provide a framework for investigating the impact of specific mutations and polymorphisms in SLC23A1 and help us better understand the contribution of SVCT1 to vitamin C metabolism in health and disease. PMID: 18094143
    15. The results suggest that uncharged His51 of hSVCT1, directly or indirectly, contributes to substrate binding through the hydrogen bond. PMID: 18247577
    16. SVCT1 may be targeted to facilitate the delivery of drugs with low bioavailability by conjugating with ascorbic acid PMID: 18417304
    17. N-Glycosylation is therefore essential for SVCT1 functionality. PMID: 18619416
    18. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association with colorectal adenoma risk. PMID: 18791929
    19. Results using short interfering RNA suggest that in HepG2 cells, decreasing hSVCT2 message levels reduces the overall ascorbic acid uptake process more than decreasing hSVCT1 message levels. PMID: 18845575
    20. Results describe the membrane topology of human SVCT1 and SVCT2, and the role of glycosylation on protein transport. PMID: 19379732
    21. HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression PMID: 19741195
    22. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18818748

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Xanthine/uracil permease family, Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily
  • 組織特異性:
    Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
  • 數據庫鏈接:

    HGNC: 10974

    OMIM: 603790

    KEGG: hsa:9963

    STRING: 9606.ENSP00000302851

    UniGene: Hs.643467



主站蜘蛛池模板: 性暴力欧美猛交在线播放| 热99re久久精品国产首页免费| 色伦专区97中文字幕| 成 人 网 站 免费观看| 777久久精品一区二区三区无码| 成人网站免费大全日韩国产| 欧美日产国产新一区| 同性女女黄h片在线播放| 大伊香蕉精品一区二区| 牲交欧美兽交欧美| 精品乱码一区二区三区四区 | 精品无码av不卡一区二区三区| 少妇与子乱在线观看| 久久久久人妻精品区一三寸| 粗大黑人巨精大战欧美成人| 色噜噜狠狠色综合日日| 精品国产美女av久久久久| 日本一区二区三区免费播放视频站| 欧美最新精品videossexohd| 毛片免费视频肛交颜射免费视频 | 日本无卡码高清免费v| 精品无码国产一区二区三区av | 香蕉久久国产av一区二区| 精品福利一区二区三区免费视频| 国产乱子伦三级在线播放| 亚洲中文字幕无码天然素人| 精品日产一卡2卡三卡4卡在线| 东京无码熟妇人妻av在线网址| 国产精品538一区二区在线| 乱中年女人伦av二区| 丰满熟女高潮毛茸茸欧洲视频 | 久久婷婷五月综合色欧美蜜芽 | 人妻久久久精品99系列2021| 亚洲色欲色欲综合网站| 国产精品.xx视频.xxtv| 国产成人综合久久精品推下载| 俺去啦俺来也五月天| 肉色超薄丝袜脚交一区二区| 解开人妻的裙子猛烈进入| 人妻少妇-嫩草影院| 肉体裸交137日本大胆摄影|