在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC22A8 Antibody

  • 中文名稱:
    SLC22A8兔多克隆抗體
  • 貨號(hào):
    CSB-PA855047ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: SLC22A8antibody IgG at 1.62μg/ml + Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 60, 61, 47, 12, 50 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA855047ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA855047ESR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SLC22A8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC22A8
  • 別名:
    hOAT3 antibody; OAT3 antibody; Organic anion transporter 3 antibody; S22A8_HUMAN antibody; SLC22A8 antibody; Solute carrier family 22 (organic anion transporter); member 8 antibody; Solute carrier family 22 member 8 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Solute carrier family 22 member 8 protein (473-542AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
  • 基因功能參考文獻(xiàn):
    1. Sgk1 stimulated OAT3 transport activity by interfering with the inhibitory effect of Nedd4-2 on the transporter. This study provides important insights into how OAT3-mediated drug elimination is regulated in vivo. PMID: 28608480
    2. SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort. PMID: 28371506
    3. The putative promoter sequences from hOAT1 (SLC22A6) and hOAT3 (SCL22A8) were cloned into a reporter plasmid. PMID: 26277839
    4. PPIs inhibit [(3)H]MTX transport via hOAT3 inhibition. PMID: 25239859
    5. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter. PMID: 25477469
    6. Pemetrexed is a superior substrate to methotrexate for hOAT3. PMID: 24042472
    7. In HEK293-Flp-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01]. PMID: 23649425
    8. High urine OAT1, OAT3 and OAT4 is associated with severe acute kidney injury. PMID: 21945944
    9. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 PMID: 21865262
    10. Interaction of human OAT3 with 2,3-dimercapto-1-propanesulfonic acid (DMPS) determines the effect of human OAT3 on basolateral DMPS uptake in rabbit renal proximal tubules. PMID: 20237588
    11. Angiotensin II inhibited hOAT3 activity through the activation of PKCalpha, which led to an acceleration of hOAT3 endocytosis. PMID: 19878671
    12. polymorphisms in the OAT3 gene did not appear to be associated with changes in renal and tubular secretory clearance of pravastatin PMID: 12811365
    13. OAT3 plays an important role for anionic drug secretion in patients with renal diseases; expression levels of drug transporters such as OAT3 may be related to the alteration of renal drug secretion. PMID: 14984259
    14. data suggest that genetic variation in OAT3 may contribute to variation in the disposition of drugs PMID: 16291576
    15. These results indicate that the tissue-specific expression of hOAT3 might be regulated by the concerted effect of genetic (HNF1alpha and HNF1beta) and epigenetic (DNA methylation) factors. PMID: 16793932
    16. urinary excretion of topotecan hydroxyl acid is accounted for by transport via OAT3, as well as glomerular filtration, in both rats and humans PMID: 17556638
    17. Inhibition of renal uptake (via OAT3) and efflux processes (via MRP2 and MRP4) explains the possible sites of drug-drug interaction for methotrexate with probenecid and some NSAIDs, including their glucuronides. PMID: 17578901
    18. hOAT3 contributes to the renal uptake of rosuvastatin PMID: 17585018
    19. The five regulatory single nucleotide polymorphism(SNP)s of OAT3 identified in nephrectomized patients are unlikely to influence OAT3 mRNA expression or promoter activity. PMID: 18414781

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 組織特異性:
    Expressed in kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10972

    OMIM: 607581

    KEGG: hsa:9376

    STRING: 9606.ENSP00000337335

    UniGene: Hs.266223



主站蜘蛛池模板: 丁香婷婷激情综合俺也去| 日韩精品一区二区午夜成人版| 少妇被爽到高潮动态图| 刺激性视频黄页| 天天综合色天天综合色h| 亚洲色无码中文字幕在线| 人妻无码中文久久久久专区| 国产欧美另类久久精品蜜芽| 无码高潮又爽又黄a片日本动漫| 国产亚洲精品久久久久久彩霞| 欧美噜噜久久久xxx| 天堂√最新版中文在线地址| 国产成人午夜福利在线播放| 中国国产1级毛卡片| 国产又粗又猛又爽又黄| 久久亚洲国产精品成人av秋霞 | 亚洲欧美综合一区二区三区| 免费精品国偷自产在线2020| 久久久亚洲精品一区二区三区| 99精品免费久久久久久久久日本| 最新色国产精品精品视频| 激情综合五月丁香亚洲| 亚洲精品国偷拍自产在线观看蜜桃| 亚洲国产一区二区三区| 亚洲午夜无码极品久久| 国产av无码精品色午夜| 天天躁日日躁狠狠躁免费麻豆| 欧美牲交a欧美牲交aⅴ图片| 高清av熟女一区| 中国女人内谢69xxxx免费视频| 国产一区二区| 亚洲欧洲自拍拍偷精品 美利坚| 国产成人a无码短视频| 精品国产制服丝袜高跟| 国产亚洲欧美另类一区二区| 国产sm精品调教视频网址| 国产人成无码视频在线观看| 囯产精品一品二区三区| 97精品国产久热在线观看| 少妇裸体性生交| 无码人妻精品一区二区三区久久久|