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  4. SLC17A3 Antibody, Biotin conjugated

SLC17A3 Antibody, Biotin conjugated

  • 中文名稱：
    SLC17A3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA021419LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLC17A3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC17A3
  • 別名：
    SLC17A3 antibody; NPT4 antibody; Sodium-dependent phosphate transport protein 4 antibody; Na(+)/PI cotransporter 4 antibody; Sodium/phosphate cotransporter 4 antibody; Solute carrier family 17 member 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
  • 基因功能參考文獻：
    1. Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004). PMID: 27772792
    2. hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner. PMID: 21778665
    3. variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of para-aminohippurate, bumetanide, estrone and urate; SNPs may contribute to inter-individual differences in disposition of anionic drugs and certain endogenous organic anions PMID: 21282933
    4. Genetic variants within SLC2A9,ABCG2 and SLC17A3 are associated with uric acid levels PMID: 20053405
    5. a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. PMID: 20810651
    6. SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. PMID: 20162743
    7. mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex PMID: 15505377

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  • 亞細胞定位：
    [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family
  • 組織特異性：
    Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).
  • 數據庫鏈接：

    HGNC: 10931

    OMIM: 611034

    KEGG: hsa:10786

    STRING: 9606.ENSP00000380250

    UniGene: Hs.327179



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