在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC12A6 Antibody

  • 中文名稱:
    SLC12A6兔多克隆抗體
  • 貨號:
    CSB-PA539726
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA539726(SLC12A6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA539726(SLC12A6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SLC12A6
  • 別名:
    ACCPN antibody; Electroneutral potassium-chloride cotransporter 3 antibody; Furosemide sensitive KCl cotransporter 3 antibody; Gaxp antibody; K-Cl cotransporter 3 antibody; KCC 3 antibody; KCC 3A antibody; KCC 3B antibody; KCC3 A antibody; KCC3 antibody; KCC3 B antibody; KCC3A antibody; KCC3B antibody; Potassium chloride cotransporter 3 antibody; Potassium chloride cotransporter KCC3a S3 antibody; S12A6_HUMAN antibody; SLC12 A6 antibody; SLC12A 6 antibody; SLC12A6 antibody; Solute carrier family 12 (potassium/chloride transporters); member 6 antibody; Solute carrier family 12 member 6 antibody; Solute carrier family 12; member 6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human SLC12A6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
  • 基因功能參考文獻:
    1. Neurodegenerative deficits in hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum are primarily caused by an axonopathy superimposed upon abnormal development, affecting peripheral but also central nervous system axons, all ultimately because of a genetic defect in the axonal cotransporter KCC3. PMID: 27230413
    2. These results suggest that the function of the peripheral nervous system depends on finely tuned, kinase-regulated KCC3 activity and implicate abnormal cell volume homeostasis as a previously unreported mechanism of axonal degeneration. PMID: 27485015
    3. These results suggest that the expression of KCC3 in ESCC may affect cellular invasion and be related to a worse prognosis in patients with ESCC. PMID: 25110711
    4. SPAK may promote KCC3-mediated cervix tumor aggressiveness via the NF-kappaB/p38 MAPK/MMP2 axis. PMID: 24655550
    5. SLC12A6 has been shown to be causative in Andermann Syndrome. PMID: 24341143
    6. serine residue 96 of human KCC3 is a third site that has to be dephosphorylated for full activation of the cotransporter during hypotonicity. PMID: 24043619
    7. mis-trafficking of mutant protein is an important pathophysiological feature of HMSN/ACC causative KCC3 mutations. PMID: 21628467
    8. Neuropathic features of hereditary motor and sensory neuropathy/agenesis of corpus callosum in transgenic mouse lines are predominantly due to a neuronal KCC3 deficit, while the auditory impairment is due to loss of non-neuronal KCC3 expression. PMID: 22423107
    9. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions. PMID: 21613606
    10. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity PMID: 21733850
    11. mutations of the KCC3 gene may result in non-syndromic childhood onset of demyelinating hereditary motor and sensory neuropathy PMID: 20020398
    12. human osteoblasts express functional K-Cl cotransporters in their cell membrane that seem to be able to induce the indirect activation of volume-sensitive Cl- channels by KCl through an increase in the intracellular ions, water influx and cell swelling. PMID: 12637262
    13. all of the CCCs examined (NKCC1, NKCC2, KCC1, KCC3, and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site PMID: 12657561
    14. KCC activation by IGF-1 plays an important role in IGF-1 signaling to promote growth and spread of gynecological cancers. PMID: 15262997
    15. Not only truncating but also missense mutations of the KCC3 gene are associated with Andermann syndrome. PMID: 16606917
    16. Among patients with early-stage node-negative breast cancer, disease-free survival (DFS) and overall survival (OS) curves were significantly different based on IGF-1 and KCC expression. PMID: 17133354
    17. KCC3 mutations in exon 22 constitute a recurrent mutation site for hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC), regardless of ethnic origin. PMID: 17893295
    18. KCC3 down-regulates E-cadherin/beta-catenin complex formation by inhibiting transcription of E-cadherin gene and accelerating proteosome-dependent degradation of beta-catenin protein PMID: 18006853
    19. study provides evidence that the upstream SLC12A6 G/A promoter SNP is functional not only by changing the DNA primary structure but also by influencing the allelic epigenotype and consequently by influencing the chromatin organization PMID: 18536702
    20. Using a yeast 2-hybrid it was discovered that the C-terminal domain of KCC3, that is lost in most hereditary motor and sensory neuropathy with agenesis of the corpus callosum-causing mutations, directly interacts with brain-specific creatine kinase. PMID: 18566107
    21. Study identified two sites in KCC3 that are rapidly dephosphorylated in hypotonic conditions in cultured cells and human red blood cells in parallel with increased transport activity. PMID: 19665974

    顯示更多

    收起更多

  • 相關疾病:
    Agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
  • 亞細胞定位:
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC12A transporter family
  • 組織特異性:
    Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proxi
  • 數據庫鏈接:

    HGNC: 10914

    OMIM: 218000

    KEGG: hsa:9990

    STRING: 9606.ENSP00000452776

    UniGene: Hs.510939



主站蜘蛛池模板: 97无码免费人妻超级碰碰夜夜| 两性色午夜免费视频| 国产偷窥熟妇高潮呻吟| 国产精品久久久久久久久久久不卡 | 人妻丰满熟妇av无码区乱| 在线看片免费人成视频久网| 亚欧无线一线二线三线区别| 日韩一区二区三区射精| 内谢少妇xxxxx8老少交| 免费女人高潮流视频在线观看| 国产精品对白刺激久久久| 久久久久无码精品国产不卡| 久久精品成人免费国产| 人狥杂交一区欧美二区| 欧美真人性做爰一二区| 国产92成人精品视频免费| 亚洲 中文 欧美 日韩 在线| 99久久国产自偷自偷免费一区| 亚洲 欧美 中文 日韩aⅴ| 中文字幕无码家庭乱欲| 久久精品99久久香蕉国产色戒| 成在人线av无码免观看午夜网 | 精品人无码一区二区三区| 在线看片人成视频免费无遮挡| 国产精品99久久不卡| 曰本大码熟中文字幕| 亚洲 欧美精品suv| 国产成人综合在线视频| 性生交大片免费看女人按摩摩| 久久九九有精品国产23百花影院 | 一二三四视频在线观看日本| 久久人人做人人爽人人av | 高潮好爽视频在线观看| 麻豆果冻传媒2021精品传媒一区| 国产成人精品视频一区二区不卡| 国产亚洲视频在线观看播放| 中国少妇videos呻吟| 国产午夜福利视频在线观看| 日本真人做爰免费的视频| 亚洲综合色婷婷六月丁香宅男大增 | 在线观看国产精品av|