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SLC12A5 Antibody, Biotin conjugated

  • 中文名稱:
    SLC12A5兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA863965LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC12A5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC12A5
  • 別名:
    Electroneutral potassium chloride cotransporter 2 antibody; Electroneutral potassium-chloride cotransporter 2 antibody; Erythroid K Cl cotransporter 2 antibody; Furosemide sensitive K Cl cotransporter antibody; hKCC2 antibody; K-Cl cotransporter 2 antibody; KCC 2 antibody; KCC2 antibody; KIAA1176 antibody; Neuronal K Cl cotransporter antibody; Neuronal K-Cl cotransporter antibody; Potassium Chloride Cotransporter antibody; Potassium chloride transporter 5 antibody; rKCC2 antibody; S12A5 antibody; S12A5_HUMAN antibody; SLC12A5 antibody; Solute carrier family 12 (potassium chloride transporter) member 5 antibody; Solute carrier family 12 member 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier family 12 member 5 protein (944-1071AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
  • 基因功能參考文獻:
    1. the long-time considered "neuron-specific" KCC2 co-transporter is expressed in pancreatic islet beta-cells where it modulates Ca(2+)-dependent insulin secretion. PMID: 28496181
    2. These data clearly demonstrated that partially disrupted neuronal Cl(-) extrusion, mediated by two types of differentially impaired KCC2 mutant in an individual, causes epilepsy of infancy with migrating focal seizures. PMID: 27436767
    3. Study describes the developmental patterns of cation-chloride cotransporters in the human brain from the fetal stage to senescence. Expression of KCC2 and its functionally associated proteins begins in early fetal period. PMID: 26428952
    4. The authors show that APP can physically interact with KCC2, a neuron-specific K(+)-Cl(-) cotransporter that is essential for Cl(-) homeostasis and fast GABAergic inhibition. PMID: 28054918
    5. SLC12A5 promoted the migration and invasion of BUC by enhancing MMP-7 expression. PMID: 28333147
    6. Study shows that the overall expression of potassium-chloride cotransporter-2 is increased in the hippocampi of temporal lobe epilepsy patients. PMID: 26427846
    7. Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. These oscillations included transient discharges leading to ictal-like field events with frequency spectra as in vitro Restoration of KCC2 function suppressed seizure activity and thus may present a useful therapeut PMID: 27852771
    8. The KCC2 exerts specific functions for the maturation of glycinergic synapses in cultured spinal cord neurons. PMID: 26780567
    9. SLC12A5 plays a pivotal oncogenic role in colorectal carcinogenesis; its overexpression is an independent prognostic factor of patients with CRC. PMID: 25947013
    10. the functional deficit of KCC2 may offer an explanation for the delayed onset of Rett symptoms. PMID: 26733678
    11. A KCC2 mutation causes epilepsy of infancy with migrating focal seizures. Decreased KCC2 expression, reduced protein glycosylation and impaired Cl- extrusion contribute to loss of KCC2 activity, impairing synaptic inhibition and promoting excitability. PMID: 26333769
    12. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence. PMID: 26126716
    13. a novel signaling pathway that couples KCC2 to the cytoskeleton and regulates the formation of glutamatergic synapses. PMID: 26056138
    14. These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE. PMID: 24928908
    15. KCC2-R952H from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation. PMID: 24668262
    16. Functional characterization of mutant SLC12A5 revealed its potential oncogenic effect in colon cancer. PMID: 24699064
    17. Reduced KCC2/NKCC1 ratio in the cerebrospinal fluid of Rett Syndrome patients suggests a disturbed process of GABAergic neuronal maturation and open up a new therapeutic perspective. PMID: 23894354
    18. Disrupted KCC2 activity seems to be involved in neuropathic pain, epilepsy, motor spasticity, stress and schizophrenia. PMID: 23621303
    19. BPA can disrupt Kcc2 gene expression through epigenetic mechanisms PMID: 23440186
    20. Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the dorsolateral prefrontal cortex associated with schizophrenia PMID: 22496567
    21. Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential. PMID: 22082832
    22. KCC2 is widely expressed in several human cancer cell lines and serves to increase cervical tumourigenesis via an ion transport-independent mechanism PMID: 21911617
    23. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions. PMID: 21613606
    24. levels of KCC2 mRNA and protein were significantly decreased in the neurons around large abnormal neurons in focal cortical dysplasia PMID: 21256718
    25. analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4 PMID: 20516068
    26. chromosome 20 mapping PMID: 11701957
    27. Expression of hKCC2 cRNA in Xenopus laevis oocytes results in significant Cl(-)-dependent (86)Rb(+) uptake under isotonic conditions PMID: 12106695
    28. human osteoblasts express functional K-Cl cotransporters in their cell membrane that seem to be able to induce the indirect activation of volume-sensitive Cl- channels by KCl through an increase in the intracellular ions, water influx and cell swelling. PMID: 12637262
    29. GABAergic transmission is influenced by the neuronal expression chloride-extruding K(+)-Cl(-) cotransporter KCC2--REVIEW PMID: 15528236
    30. KCC2 expression is not only necessary but is also sufficient for ending the depolarizing period of GABA in developing cortical neurons PMID: 15932617
    31. constitutive K(+)-Cl(-) cotransport mediated by KCC2 is completely independent of serine-threonine phosphatase activity PMID: 16291749
    32. decrease in the spontaneous activity transients was associated with a developmental up-regulation of the neuronal chloride extruder K+-Cl- cotransporter 2 PMID: 16324114
    33. PKC-dependent phosphorylation of KCC2 may play a central role in modulating both the functional expression of this critical transporter in the brain and the strength of synaptic inhibition PMID: 17693402
    34. The novel KCC2a isoform differs from the only previously known KCC2 isoform (now termed KCC2b) by 40 unique N-terminal amino acid residues, including a putative Ste20-related proline alanine-rich kinase-binding site. PMID: 17715129
    35. the two isoforms can be coimmunoprecipitated from the neonatal brain, suggesting the presence of endogenous KCC2a-KCC2b heteromers. PMID: 19307176
    36. membrane rafts render KCC2 inactive and NKCC1 active PMID: 19686239

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  • 相關疾病:
    Epileptic encephalopathy, early infantile, 34 (EIEE34); Epilepsy, idiopathic generalized 14 (EIG14)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC12A transporter family
  • 組織特異性:
    Brain specific. Detected in neuronal cells.
  • 數據庫鏈接:

    HGNC: 13818

    OMIM: 606726

    KEGG: hsa:57468

    STRING: 9606.ENSP00000387694

    UniGene: Hs.21413



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