在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC12A4 Antibody, Biotin conjugated

  • 中文名稱:
    SLC12A4兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA892363LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC12A4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC12A4
  • 別名:
    Electroneutral potassium chloride cotransporter 1 antibody; Electroneutral potassium-chloride cotransporter 1 antibody; Erythroid K Cl cotransporter 1 antibody; Erythroid K-Cl cotransporter 1 antibody; FLJ40489 antibody; hKCC 1 antibody; hKCC1 antibody; KCC 1 antibody; KCC1 antibody; Potassium transport protein antibody; Potassium/chloride cotransporter 1 antibody; S12A4_HUMAN antibody; Slc12a4 antibody; Solute carrier family 12 (potassium/chloride transporters) member 4 antibody; Solute carrier family 12 member 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier family 12 member 4 protein (601-900AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4 has no transport activity.
  • 基因功能參考文獻:
    1. data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. PMID: 28093242
    2. Insulin-like growth factors I can induce the upregulation of KCC1 gene, and KCC1 gene participates in the invasion ability of HEC-1B cells through the ERK signaling pathway. PMID: 21666489
    3. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity PMID: 21733850
    4. human osteoblasts express functional K-Cl cotransporters in their cell membrane that seem to be able to induce the indirect activation of volume-sensitive Cl- channels by KCl through an increase in intracellular ions, water influx and cell swelling. PMID: 12637262
    5. loss-of-function KCC mutant cervical cancer cells exhibit inhibited cell growth accompanied by decreased activity of cell cycle gene products PMID: 12902337
    6. the KCC1 gene promoter lacks a TATA box and is composed of an initiator element (InR) and a downstream promoter element (DPE) PMID: 14976052
    7. Hb polymerisation and sickling could be dissociated from the abnormal response of KCC to deoxygenation observed in HbS-containing red cells. PMID: 15039017
    8. KCC activation by IGF-1 plays an important role in IGF-1 signaling to promote growth and spread of gynecological cancers. PMID: 15262997
    9. IGF-II (insulin-like growth factors-2) can enhance KCC1 (KC1 co-transport-1) gene expression in cervical cancer cells through signal transduction pathways PMID: 19317253

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC12A transporter family
  • 組織特異性:
    Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular con
  • 數據庫鏈接:

    HGNC: 10913

    OMIM: 604119

    KEGG: hsa:6560

    STRING: 9606.ENSP00000395983

    UniGene: Hs.10094



主站蜘蛛池模板: 国产乱人伦偷精品视频免| 中文字幕亚洲乱码熟女在线 | 国产精品福利一区二区| 97人妻精品一区二区三区| 成人精品一区二区三区电影免费 | 秋霞特色aa大片| 久久综合色鬼综合色| 真实国产乱子伦精品一区二区三区| 亚洲精品午夜久久久伊人| 人人妻人人澡人人爽欧美一区双| 中国女人和老外的毛片| 亚洲日本一区二区三区在线播放| 在线播放国产麻豆va剧情| 国产成人精品日本亚洲专区61| 国产精品毛片av在线看| 无码av岛国片在线播放| 亚洲国产中文在线视频| 日本熟妇大屁股人妻| 日韩精品无码一本二本三本色| 国产成熟妇女性视频电影| 无码孕妇孕交在线观看| 亚洲熟妇久久精品| 成人无码精品一区二区三区| 亚洲国产成人爱av网站| 狠狠色噜噜狠狠狠7777奇米| 久久www香蕉免费人成| 国产成人亚洲综合无码品善网| 欧美人与牲动交xxxx| 中文字幕丰满乱孑伦无码专区| 强开小婷嫩苞又嫩又紧韩国视频| 国产亚洲久久久久久久| 欧美va亚洲va在线观看| 老湿机69福利区18禁网站| 国产v亚洲v天堂a无码99| 熟女性饥渴一区二区三区| 无遮挡又爽又刺激的视频| 亚洲成av人无码中文字幕| 国产精品喷浆| 欧美午夜精品久久久久久浪潮| 免费国产高清毛不卡片基地| 日韩在线不卡免费视频一区|