在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SLAMF6 Antibody, Biotin conjugated

SLAMF6 Antibody, Biotin conjugated

  • 中文名稱：
    SLAMF6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA021368LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLAMF6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Activating NK receptor antibody; CD352 antibody; KALI antibody; KALIb antibody; LY108 antibody; MGC104953 antibody; Natural killer T and B cell antigen antibody; NK T B antigen antibody; NK-; T-; and B-cell antigen antibody; NK-T-B-antigen antibody; NTB A antibody; NTB-A antibody; NTBA antibody; NTBA receptor antibody; SF2000 antibody; SLAF6_HUMAN antibody; SLAM family member 6 antibody; SLAM family member 6 precursor antibody; SLAM Family Receptor antibody; Slamf6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SLAM family member 6 protein (248-331AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A. In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity.
  • 基因功能參考文獻：
    1. these results showed that the NTB-A/SAP pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis PMID: 28546549
    2. in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans PMID: 28373584
    3. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'. PMID: 26878112
    4. our data reveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate restimulation-induced cell death of activated human T cells. PMID: 24688028
    5. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules. PMID: 23528733
    6. Data indicate that the dominance of the SLAMF3/SLAMF6 pathway in inducing IL-17A production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A promoter. PMID: 22989874
    7. SLAMF3 and SLAMF6 T cell surface expression and IL-17 levels significantly correlate with disease activity in systemic lupus erythematosus patients PMID: 22184727
    8. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 and IL-2 cytokine production PMID: 21231893
    9. Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells. PMID: 21075351
    10. regulation of interferon-gamma secretion, and not interleukin-4 in vitro, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response PMID: 14988414
    11. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells. PMID: 15153464
    12. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2 PMID: 16920955
    13. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. PMID: 17045824

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients.
  • 數據庫鏈接：

    HGNC: 21392

    OMIM: 606446

    KEGG: hsa:114836

    STRING: 9606.ENSP00000357036

    UniGene: Hs.492348



主站蜘蛛池模板： 无码人妻一区二区三区在线| 国内高清a自拍视频| 99久久国产露脸精品竹菊传媒| 影音先锋男人av鲁色资源网| 色诱久久久久综合网ywww| 免费人成自慰网站| 中文字幕日韩精品无码内射| 日日碰狠狠躁久久躁96| 中文字幕人妻熟在线影院| 日韩免费视频| 无尺码精品产品视频| 久久婷婷六月综合色液啪| 天天天狠天天碰天天爱| 欧美丰满熟妇bbbbbb| 狠狠色丁香婷婷久久综合| 国产在线码观看超清无码视频| 亚洲跨种族黑人xxxxx| 爽爽影院免费观看视频| 亚洲一卡2卡三卡四卡精品| 99久久亚洲综合精品成人| 国产视频一区二区| 精品久久人人妻人人做精品| 久久久喷潮一区二区三区| 中文字幕人妻丝袜成熟乱| 国产在线无码一区二区三区视频| www.-级毛片线天内射视视| 亚洲中文字幕乱码一区| 加勒比东京热无码一区| 日本精品少妇一区二区三区| 久久精品人妻无码一区二区三区v 国产薄丝脚交视频在线观看 | 色综合无码av网站| 欧美激情a∨在线视频播放| 国产美女无遮挡裸色视频| 99re久久热在这里精品| 中文字幕av一区二区三区| 中文字幕无码中文字幕有码| av天堂中av世界中文在线播放| 在线日韩av免费永久观看| 亚洲无线码在线一区观看| 东京热毛片无码dvd一二三区| 国产精品18禁污污网站|