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  4. SLA Antibody, FITC conjugated

SLA Antibody, FITC conjugated

  • 中文名稱：
    SLA兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA613387LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLA
  • 別名：
    hSLAP antibody; SLA 1 antibody; sla antibody; SLA1 antibody; SLAP 1 antibody; SLAP antibody; SLAP-1 antibody; SLAP1 antibody; SLAP1_HUMAN antibody; Src like adapter antibody; Src like adapter protein 1 antibody; Src like adaptor antibody; SRC-like-adapter antibody; Src-like-adapter protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Src-like-adapter protein (2-276AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
  • 基因功能參考文獻：
    1. results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases PMID: 25800872
    2. Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control PMID: 24284075
    3. upon ligand stimulation SLAP stably associates with Flt3 through multiple phosphotyrosine residues in Flt3. SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3-ITD mutation PMID: 23300935
    4. These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling. PMID: 22798681
    5. Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids. PMID: 19631983
    6. The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution. PMID: 16521218

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  • 亞細胞定位：
    Cytoplasm. Endosome.
  • 組織特異性：
    Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 10902

    OMIM: 601099

    KEGG: hsa:6503

    STRING: 9606.ENSP00000394049

    UniGene: Hs.75367



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