在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SIVA1 Antibody

  • 中文名稱:
    SIVA1兔多克隆抗體
  • 貨號:
    CSB-PA021347GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SIVA1
  • 別名:
    Apoptosis regulatory protein Siva antibody; CD27 binding (Siva) protein antibody; CD27-binding protein antibody; CD27BP antibody; Siva 1 antibody; Siva 2 antibody; SIVA_HUMAN antibody; Siva1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SIVA1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
  • 基因功能參考文獻:
    1. Loss of SIVA1 expression is associated with nasopharyngeal carcinoma. PMID: 26406409
    2. These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53. PMID: 25813352
    3. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells. PMID: 25374190
    4. electrical stimulation -inducible SIVA1 modulates p53 activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization PMID: 25431847
    5. SIVA1 interacts with RAD18 and serves as a molecular bridge between RAD18 and PCNA, thus targeting the E3 ligase activity of RAD18 onto PCNA. PMID: 24958773
    6. Siva1 promotes the ubiquitination and degradation of ARF, which in turn affects the stability of p53. PMID: 23462994
    7. Upon stimulation of thromboxane A2, degradation of Siva1 is impeded, resulting in an accumulation of the protein, which translocates from the nucleus to the cytosol. PMID: 22343716
    8. negative regulator of IL-2 gene expression in Treg cells PMID: 21955384
    9. Data show that low levels of Siva1 and Ser16-phosphorylated stathmin correlate with high metastatic states of breast cancer cells. PMID: 21768358
    10. These findings suggest that the caspase-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication. PMID: 21048035
    11. These results suggest that Siva-mediated unprovoked apoptosis is not likely to be involved in the pathogenesis of Familial Mediterranean fever. PMID: 20934406
    12. Siva-1 forms a functional complex with Tyk2 and participates in the transduction of signals that inhibit B lymphocyte growth. PMID: 20727854
    13. Siva-1 putative amphipathic helical region (SAH) binds BCL-XL and sensitizes cells to UV radiation induced apoptosis PMID: 14739602
    14. Overexpression of Siva-1 in T lymphocytes triggers the activation of a caspase-dependent death pathway including a pivotal mitochondrial step. Both N- and C-terminal domains of Siva proteins display the ability to induce a cell death process in T cells. PMID: 15034012
    15. Siva-1 has a role, through its inhibitory effect on NF-kappaB activity, in TCR-mediated AICD with implications in peripheral tolerance, T-cell homeostasis and cancer PMID: 16491128
    16. determined the N-terminal part of Siva as the binding region for CD27; the peroxisomal membrane protein PMP22 is a new interaction partner of Siva and may be involved in the host response against CVB3. PMID: 16683188
    17. Confirming the anti-apoptotic role of HPV-16 E7 in the HaCaT cellular model, evaluated by nuclear morphology, it was also found that Siva-1 expression produced a significant increase of the apoptotic rate in UV radiation-exposed HaCaT cells. PMID: 17348035
    18. Results suggest that Siva-1 might participate in the CD4-initiated signaling apoptotic pathway induced by the HIV-1 envelope in T-lymphoid cells. PMID: 17653867
    19. lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival PMID: 17965021
    20. Data show that Siva and pyrin are co-expressed, and that pyrin modulates the apoptotic response to oxidative stress mediated by Siva. PMID: 18330885
    21. Telethonin might be involved in CVB3-mediated cell damage and in the resulting cardiac dysfunction due to the interaction with Siva. PMID: 18849585
    22. Siva-1 has a role in negatively regulating NF-kappaB activation by targeting TRAF2. PMID: 19392652
    23. Siva1 is an important mediator for the Hdm2-p53 interaction and is an integral component of the negative feedback mechanism for p53 inhibition. PMID: 19590512

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=In the nucleus, accumulates in dot-like structures.
  • 組織特異性:
    Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
  • 數據庫鏈接:

    HGNC: 17712

    OMIM: 605567

    KEGG: hsa:10572

    STRING: 9606.ENSP00000329213

    UniGene: Hs.112058



主站蜘蛛池模板: 国产中年熟女高潮大集合| 国产午夜福利精品久久2021| 亚洲人成无码网站久久99热国产| 老子午夜精品无码| 久草热8精品视频在线观看| 成人a毛片视频免费看| 中文字幕人成人乱码亚洲电影| 非洲黑人最猛性xxxx交| 久久精品免视看国产成人明星| 国产永久免费观看的黄网站| 精品国产自在现线看久久| 国产92成人精品视频免费| 少妇被粗大的猛烈进出图片| 欧洲精品无码一区二区三区在线播放| 成人a片产无码免费视频在线观看| 国产成人欧美一区二区三区| 亚洲日韩中文字幕无码一区| 国产熟妇高潮呻吟喷水| 欧美变态另类牲交| 日韩av片无码一区二区不卡电影 | 亚洲欧美在线观看品| 久碰人妻人妻人妻人妻人掠| 亚洲 精品 综合 精品 自拍| 强迫大乳人妻中文字幕| 久久精品女同亚洲女同| 国产又黄又爽又色的免费视频| 成人免费看片又大又黄| 97视频精品全国免费观看| 狠狠色噜噜狠狠狠狠蜜桃| 亚洲日韩中文字幕在线播放| 无罩大乳的熟妇正在播放| 国产69囗曝吞精在线视频| 99久热国产精品视频尤物| 免费无码黄网站在线看| 无码精品国产dvd在线观看9久| 亚洲国产精品久久久久4婷婷| 男女高潮激烈免费观看| 亚洲码国产精品高潮在线| 精品国产一区二区av麻豆不卡| 国产精品卡一卡2卡三卡网站| 老熟女乱子伦|