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SIRPB1 Antibody

  • 中文名稱：
    SIRPB1兔多克隆抗體
  • 貨號：
    CSB-PA001428
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using CD172b Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SIRPB1 antibody; Signal-regulatory protein beta-1 antibody; SIRP-beta-1 antibody; CD172 antigen-like family member B antibody; CD antigen CD172b antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD172b.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.
  • 基因功能參考文獻：
    1. SIRPB1 copy-number polymorphism was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner. PMID: 25039969
    2. SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis. PMID: 19893026
    3. SIRP beta 1 is a disulfide-linked homodimer in leukocytes that regulates neutrophil transepithelial migration PMID: 16081415
    4. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in monocytes and dendritic cells.
  • 數據庫鏈接：

    HGNC: 15928

    OMIM: 603889

    UniGene: Hs.664861



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