在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SIM2 Antibody, HRP conjugated

  • 中文名稱:
    SIM2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA621763LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SIM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SIM2
  • 別名:
    bHLHe15 antibody; Class E basic helix loop helix protein 15 antibody; Class E basic helix-loop-helix protein 15 antibody; MGC119447 antibody; SIM 2 antibody; SIM antibody; Sim2 antibody; SIM2_HUMAN antibody; Single minded homolog 2 (Drosophila) antibody; Single minded homolog 2 antibody; Single-minded homolog 2 antibody; Transcription factor SIM2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Single-minded homolog 2 protein (347-433AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
  • 基因功能參考文獻:
    1. TMEM75 functions as an oncogene relying on activation of SIM2 in colorectal cancer. PMID: 29964097
    2. SIM2 increases CRT sensitivity through tumor differentiation by cooperation with ARNT. PMID: 29427302
    3. Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with prostate cancer. PMID: 28910345
    4. In SH-SY5Y cells, ethanol exposure increased Sim2 expression in a manner similar to that of cleaved caspase 3. PKA activation was required for this. Sim2 might be involved in activating caspase 3 and ethanol-induced apoptosis in SH-SY5Y cells. PMID: 25319570
    5. a single peptide containing multiple SIM2 epitopes can be used to induce both a CD4 and CD8 T cell response, providing a peptide-based vaccine formulation for potential use in immunotherapy of various cancers. PMID: 24690990
    6. Data showed that SIM2 was highly expressed in human glioma tumors and cell lines and its short form might increase the invasion of glioma cells through the alteration of epithelial-mesenchymal transition. PMID: 24909296
    7. miR-200a is downregulated in human glioma and inhibition of miR-200a caused upregulation of SIM2-s in T98G cells and promoted their motility. PMID: 24162743
    8. role for SIM2s in promoting human breast tumor differentiation and maintaining epithelial integrity. PMID: 22777354
    9. Altered expression of SIM2 and ETS2 could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome. PMID: 23343470
    10. These results suggest an involvement of SIM2 in key traits of prostate tumor cell biology. PMID: 22174909
    11. Significantly lower frequency of SIM2 C-G haplotype (rs2073601-rs2073416) was noticed in individuals with Down syndrome (P value =0.01669) and their fathers (P value=0.01185) PMID: 22048266
    12. Genetic variants of SIM2 gene may not be associated with the susceptibility to congenital scoliosis and different clinical phenotypes of CS in Chinese Han population. PMID: 20137643
    13. The SIM2 is expressed in prostate cancer(PCa) and that anti-SIM2 antibodies are detectable in PCa patients' sera implicate SIM2 as a PCa-associated antigen that is a suitable potential target for PCa immunotherapy. PMID: 19737960
    14. Isoform-specific expression of SIM2 short-form (SIM2-s) was seen selectively in colon, prostate, and pancreatic carcinomas. PMID: 12676991
    15. a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome PMID: 14701734
    16. Potential role of SIM2 in central nervous system development. SIM2 overexpression could participate in pathogenesis of mental retardation in Down syndrome. PMID: 15946822
    17. provide a direct link between SIM2-s and differentiation, and may provide a model to identify SIM2-s targets PMID: 16129820
    18. Knockdown of SIM2s in MCF-7 breast cancer cells contributed to an epithelial-mesenchymal transition associated with increased MMP2 and slug levels. PMID: 18160708
    19. Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta. PMID: 19169276
    20. SIM2s' functional interference with HIF1alpha activities on BNIP3 may indicate a novel role for SIM2s in promoting tumourigenesis. PMID: 19668230
    21. The expression of a splice variant of SIM2, SIM2s, is lost or reduced in human breast cancers. Inhibits growth and invasiveness of breast cancer cells upon ectopic expression. Represses MMP3 expression by direct binding to the MMP3 promoter. PMID: 16840439
    22. Tissue- and tumor-specific expression of both SIM2 isoforms (SIM2-s and SIM2-l), but not SIM1, were detected in the pancreatic tumor models. PMID: 14550949
    23. Stage-specific expression of the sim2-short-form protein was seen in normal matched paraffin sections of the colon tumors. In a matched set of tissues of Benign Prostatic Hyperplasia (BPH) and prostate carcinomas, sim2-s expression was detected in the BPH PMID: 12530058

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 10883

    OMIM: 600892

    KEGG: hsa:6493

    STRING: 9606.ENSP00000290399

    UniGene: Hs.146186



主站蜘蛛池模板: 少妇人妻偷人精品视频| 曰的好深好爽免费视频网站| 久爱无码免费视频在线| 黄桃av无码免费一区二区三区 | 97性无码区免费| 免费看成人毛片无码视频| 邻居少妇张开腿让我爽了在线观看 | 国产在线精品一区在线观看| 无套内射在线无码播放| 国产亚洲精品久久久久久小舞| 久久精品国产男包| 18禁无遮挡啪啪无码网站| 狠狠躁夜夜躁人人爽天天5| 亚洲日韩久热中文字幕| 国内精品久久久久久无码 | 国产午夜高清高清在线观看| 与子敌伦刺激对白播放| 国产性生交xxxxx免费| 饥渴少妇av无码影片| 产后漂亮奶水人妻无码| 无码毛片内射白浆视频| 丰满岳乱妇一区二区三区| 97久章草在线视频播放| 无人区一码卡二卡三乱码| 97久久精品亚洲中文字幕无码| 亚洲中文字幕婷婷在线| 国内精品自线在拍2020不卡| 久久精品无码专区免费| 国产99久久久久久免费看 | 国产果冻豆传媒麻婆精东| 熟妇高潮喷沈阳45熟妇高潮喷| 1000部啪啪未满十八勿入下载| 人妻av中文字幕一区二区三区| 亚洲卡一卡二乱码新区仙踪| 欧美大肥婆大肥bbbbb| 日本一道本高清一区二区| √天堂资源在线中文8在线最新版| av无码精品一区二区三区宅噜噜| 亚洲国产午夜精华无码福利| 亚洲日韩乱码中文无码蜜桃臀网站| 黄页网址大全免费观看|