在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SIGLEC7 Antibody

  • 中文名稱:
    SIGLEC7兔多克隆抗體
  • 貨號:
    CSB-PA005300
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of K562 cells using CD328 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Adhesion inhibitory receptor molecule 1 antibody; Adhesion inhibitory receptor molecule 1, siglec 7 antibody; AIRM 1 antibody; AIRM-1 antibody; AIRM1 antibody; CD328 antibody; CD328 antigen antibody; CDw328 antibody; D siglec antibody; D-siglec antibody; HLDA 8 antibody; p75 antibody; p75/AIRM1 antibody; QA79 antibody; QA79 membrane protein antibody; Sialic acid binding Ig like lectin 7 antibody; Sialic acid binding immunoglobulin like lectin 7 antibody; Sialic acid-binding Ig-like lectin 7 antibody; SIGL7_HUMAN antibody; Siglec-7 antibody; SIGLEC19P antibody; SIGLEC7 antibody; SIGLECP2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human CD328.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
  • 基因功能參考文獻:
    1. Data reported that Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Furthermore, Siglec-7 seems to play a critical role in the maintenance of an immune-suppressive anti-inflammatory microenvironment, which is lost in diabetes, and may contribute to the manifestation and progression of this metabolic syndrome. PMID: 28378743
    2. NK cells with Siglec-7neg phenotype possess a high and sustainable killing activity and have the capability to eliminate a NK-resistant leukemia cell and hypersialylated tumor cells PMID: 29617289
    3. CD56bright NK cells from obese subjects had a reduced expression of Siglec-7 PMID: 28786023
    4. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities. PMID: 27312286
    5. Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils. PMID: 24810846
    6. These results show that Siglec-7 binds HIV-1 via gp120 and contributes to enhance the susceptibility to infection of CD4 positive T cells and monocyte-derived macrophages. PMID: 24330394
    7. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity. PMID: 24569453
    8. Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis. PMID: 22933622
    9. Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition. PMID: 23029261
    10. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors. PMID: 11774609
    11. high resolution crystal structures of this protein; insights into ligand specificity of this family of proteins PMID: 12438315
    12. Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells. PMID: 12778482
    13. x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1 PMID: 14747738
    14. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity PMID: 15292262
    15. Siglec-7 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2. PMID: 15557178
    16. upon pervanadate (PV) treatment, Siglec-7 recruited the protein tyrosine phosphatases Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase-1 and SHP-2 less efficiently than did other inhibitory receptors PMID: 15703304
    17. structural analysis of siglec-7 in complex with sialosides PMID: 16623661
    18. Siglecs-7 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
    19. The expression levels of Siglec-7 were detectable in bone marrow plasma from AML patients and serum from normal donors. PMID: 16828866
    20. The species-specific differences in the expression expression of Siglecs in SIV infection was studied. PMID: 18331725
    21. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. PMID: 19710502

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性:
    Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 10876

    OMIM: 604410

    KEGG: hsa:27036

    STRING: 9606.ENSP00000323328

    UniGene: Hs.655393



主站蜘蛛池模板: a 'v片欧美日韩在线| 欧美激情肉欲高潮视频| 欧美一区二区三区激情| 熟女熟妇伦av网站| 九九99无码精品视频在线观看| 永久中文字幕免费视频网站| 国产最大成人亚洲精品| 国产午夜福利精品久久2021| 国产精品久久无码一区二区三区网| 日韩乱码人妻无码中文字幕久久| 国产精品国产三级国产av麻豆| 日99久9在线 | 免费| 果冻传媒亚洲区二期| 中文字幕精品亚洲无线码二区| 高潮内射免费看片| 最新国产久免费视频在线观看| 最近日本精品一卡2卡3卡4卡 | 亚洲人成网线在线播放va蜜芽| 使劲快高潮了国语对白在线| 日本丰满少妇高潮呻吟| 亚洲va在线va天堂xxxx| 高潮潮喷奶水飞溅视频无码| 华人少妇被黑人粗大的猛烈进| 女人下边被添全过视频的网址| 国产97在线 | 日韩| 亚洲va天堂va欧美ⅴa在线| 亚洲v欧美v日韩v国产v| 欧美日韩精品| 欧美性猛交xxxx乱大交极品| 18禁无遮挡羞羞污污污污免费 | 初尝黑人嗷嗷叫中文字幕| 免费三级网站| 免费无码av一区二区| 天堂在线www中文| 最新国产麻豆aⅴ精品无码| 日本猛少妇色xxxxx猛叫| 解开人妻的裙子猛烈进入| 黄网站成人片免费视频| 51福利国产在线观看午夜天堂 | 国产成人精品午夜福利在线观看| 99久视频只有精品2019|