在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SIGLEC5 Antibody

SIGLEC5 Antibody

  • 中文名稱：
    SIGLEC5兔多克隆抗體
  • 貨號：
    CSB-PA021299GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SIGLEC5
  • 別名：
    SIGLEC5; CD33L2; OBBP2; Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD antigen CD170
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human SIGLEC5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 基因功能參考文獻：
    1. PSGL1 and Siglec-5 are in close proximity at the leukocyte surface.SPSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.Siglec-5 plays a role in PSGL1-mediated leukocyte rolling and the inflammatory response in general. PMID: 27892504
    2. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory. PMID: 26459514
    3. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus. PMID: 24799499
    4. we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor. PMID: 24068891
    5. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function. PMID: 23321067
    6. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees. PMID: 22945238
    7. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. PMID: 21795693
    8. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes. PMID: 20231688
    9. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure. PMID: 12763136
    10. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation. PMID: 15769739
    11. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
    12. The expression levels of Siglec-5 were high or detectable in bone marrow plasma from AML patients and serum from normal donors. PMID: 16828866
    13. Siglec-14 and Siglec-5 appear to be the first glycan binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 indicates partial gene conversion between SIGLEC14 and SIGLEC5. PMID: 17012248
    14. Siglec-5 is identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils. PMID: 17675532
    15. Structural implications of SIGLEC5-mediated sialoglycan recognition are reported. PMID: 18022638
    16. Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival. PMID: 19596804

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from
  • 數據庫鏈接：

    HGNC: 10874

    OMIM: 604200

    KEGG: hsa:8778

    STRING: 9606.ENSP00000455510

    UniGene: Hs.310333



主站蜘蛛池模板： 少妇人妻无码专区视频| 亚洲精品宾馆在线精品酒店| 亚洲精品无码mv在线观看网站| 伦埋琪琪久久影院三级| 亚洲精品永久在线观看| 久久亚洲精品国产亚洲老地址| 久久这里只精品国产免费10| 西西人体大胆4444www| 亚洲成在人线a免费77777| 久久中文字幕人妻熟女| 无码av大香线蕉伊人久久| 寂寞骚妇被后入式爆草抓爆 | 人妻激情文学| 精品一区二区三区免费毛片爱 | 国产在线拍揄自揄拍无码视频| 国精产品一二三区精华液| www亚洲精品久久久乳| 国产无遮挡免费真人视频在线观看 | 欧美激情第1页| 亚洲va无码va在线va天堂| 手机看片精品国产福利| 18黄暴禁片在线观看| 色婷婷综合久久久久中文字幕| 日韩欧美亚洲综合久久影院d3| 亚洲嫩模喷白浆在线观看| 婷婷丁香五月中文字幕| 中文字幕人成乱码熟女香港| 丰满少妇aaaaaa爰片毛片| 777天堂麻豆爱综合视频| 免费观看全黄做爰的视频| 免费看美女部位隐私网站| 男女啪啪激烈高潮喷出gif免费| 一进一出抽搐gif| 亚洲国产精品久久久天堂麻豆宅男| 人人爽人人爽人人片a免费| 少妇爆乳无码专区| 男人扒开女人内裤强吻桶进去 | 日本xxxx少妇高清hd| 西西人体www大胆高清视频| 国产一卡三卡四卡无卡精品| 最新777第四色米奇影视|