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  4. SHROOM3 Antibody, Biotin conjugated

SHROOM3 Antibody, Biotin conjugated

  • 中文名稱：
    SHROOM3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA844740LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SHROOM3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SHROOM3
  • 別名：
    APXL3 antibody; hShrmL antibody; MSTP013 antibody; Protein Shroom3 antibody; Shrm antibody; Shrm3 antibody; SHRM3_HUMAN antibody; ShrmL antibody; Shroom family member 3 antibody; Shroom-related protein antibody; shroom3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein Shroom3 protein (1309-1571AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.
  • 基因功能參考文獻：
    1. Two protein-truncating de novo mutations in two independent cases in SHROOM3 strongly implicates this protein in severe human neural tube defects. PMID: 25805808
    2. variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effacement and impairment of the glomerular filtration barrier PMID: 25273069
    3. The SNP rs17319721 functions as a cis-acting expression quantitative trait locus of SHROOM3 that facilitates TGF-B1 signaling and contributes to allograft injury. PMID: 25437874
    4. RESULTS: rs1260326 in GCKR (beta=1.30, P = 3.23E-03), rs17319721 in SHROOM3 (beta = -1.28, P-value = 3.18E-03) and rs12917707 in UMOD (beta = 2.0, P-value = 8.84E-04) were significantly associated with baseline estimated GFR PMID: 23586973
    5. A recessive missense mutation in SHROOM3 is associated with heterotaxy syndrome. PMID: 21936905

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  • 亞細胞定位：
    Cell junction, adherens junction. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Shroom family
  • 數據庫鏈接：

    HGNC: 30422

    OMIM: 604570

    KEGG: hsa:57619

    STRING: 9606.ENSP00000296043

    UniGene: Hs.683808



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