在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SHOC2 Antibody, HRP conjugated

  • 中文名稱:
    SHOC2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA891468LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SHOC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    KIAA0862 antibody; Leucine-rich repeat protein SHOC-2 antibody; Protein soc-2 homolog antibody; Protein Sur-8 homolog antibody; Ras-binding protein Sur-8 antibody; SHOC2 antibody; SHOC2_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Leucine-rich repeat protein SHOC-2 protein (3-89AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
  • 基因功能參考文獻:
    1. Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of colorectal cancer (CRC) cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC cells. PMID: 27469030
    2. Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments. PMID: 27466182
    3. results demonstrate that PSMC5 is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner. PMID: 26519477
    4. Noonan-like syndrome has been related to the invariant c.4A > G missense change in SHOC2. PMID: 22995099
    5. Two unrelated Taiwanese patients have been described with Noonan-like syndrome with loose anagen hair who also have moyamoya disease and in whom heterozygous germline mutation in SHOC2 was found. PMID: 25858597
    6. ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of Epidermal Growth Factor, a stimulus that induces proliferation rather than differentiation in these cells. PMID: 25514808
    7. Extreme phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation in Noonan-like syndrome with loose anagen hair. PMID: 25331583
    8. A newborn heterozygous for the invariant c.4A>G missense change in SHOC2. PMID: 24458587
    9. Data show that both Shoc2 and HUWE1 are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1. PMID: 25022756
    10. Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
    11. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. PMID: 23076151
    12. targeting of Shoc2 to late endosomes may facilitate EGFR-induced ERK activation under physiological conditions of cell stimulation by EGF, and therefore, may be involved in the spatiotemporal regulation of signaling through the RAS-RAF module PMID: 22606262
    13. The p.Ser2Gly mutation demonstrated introduction of an N-myristoylation site, resulting in aberrant membrane targeting of SHOC2 and impaired translocation to the nucleus upon growth factor stimulation. PMID: 21548061
    14. 92 patients with Noonan syndrome and related disorders to characterize mutations in the SHOC2 gene were analysed. PMID: 20882035
    15. Results indicate that the Shoc2 scaffold protein modulates Ras-dependent Raf1 activation in a Ca(2+)- and calmodulin-dependent manner. PMID: 20071468
    16. Data suggest that Shoc2 regulates the spatio-temporal patterns of the Ras-ERK signaling pathway primarily by accelerating the Ras-Raf interaction. PMID: 20051520
    17. no evidence of leukemogenic SHOC2 involvement in juvenile myelomonocytic leukemia PMID: 20110435
    18. Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction PMID: 16301319
    19. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. PMID: 19684605

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    SHOC2 family
  • 數據庫鏈接:

    HGNC: 15454

    OMIM: 602775

    KEGG: hsa:8036

    STRING: 9606.ENSP00000358464

    UniGene: Hs.104315



主站蜘蛛池模板: 色一情一乱一伦一视频免费看| 就去干成人网| 久久ww精品w免费人成| 性色av一区二区三区无码| 国产在线拍偷自揄拍无码 | 深夜福利在线观看视频| 亚洲人成网站观看在线播放| 亚洲国产午夜精华无码福利| 成人免费网站视频www| 男人女人做爽爽18禁网站| 人人插人人插人人爽| 3d动漫精品啪啪一区二区| 国语精品福利自产拍在线观看| 人妻人人澡人人添人人爽人人玩| 国产日韩av一区二区三区五区| 亚洲欧洲日产国无高清码图片 | 狠狠97人人婷婷五月| 欧美巨鞭大战丰满少妇| 青草精品国产福利在线视频| 亚洲综合欧美在线一区在线播放| 一区二区在线 | 欧洲| 久久久亚洲欧洲日产国产成人无码| 国产精品黄页免费高清在线观看| 亚洲欧美日韩成人一区在线| 丰满人妻翻云覆雨呻吟视频| 亚洲午夜福利av一区二区无码| 亚洲精品欧美综合四区| 国产成人av在线一区二区三区| 天美传媒一区二区| 国产极品白嫩精品| 性色av一二三天美传媒| 浪潮av激情高潮国产精品| 国产女主播白浆在线观看| 色一情一乱一伦一区二区三区小说| 四虎影视在线永久免费观看 | 小12萝裸体视频国产| 97免费人妻在线视频| 精品人妻无码一区二区三区性| 亚洲欧洲av综合色无码| 国产美女口爆吞精普通话| 精品久久久久久中文字幕人妻最新|