在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SH3GLB1 Antibody

  • 中文名稱:
    SH3GLB1兔多克隆抗體
  • 貨號:
    CSB-PA878084LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of HepG2 cells using CSB-PA878084LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SH3GLB1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Bax interacting factor 1 antibody; Bax-interacting factor 1 antibody; Bif 1 antibody; Bif antibody; Bif-1 antibody; CGI 61 antibody; dJ612B15.2 antibody; Endophilin B1 antibody; Endophilin-B1 antibody; PPP1R70 antibody; Protein phosphatase 1 regulatory subunit 70 antibody; SH3 containing protein SH3GLB1 antibody; SH3 domain GRB2 like endophilin B1 antibody; SH3 domain-containing GRB2-like protein B1 antibody; Sh3glb1 antibody; SH3p13 antibody; SHLB1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Endophilin-B1 protein (1-365AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,SH3GLB1 Antibody (CSB-PA878084LA01HU),的標記方式是Non-conjugated。對于SH3GLB1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA878084LB01HU SH3GLB1 Antibody, HRP conjugated ELISA
    FITC CSB-PA878084LC01HU SH3GLB1 Antibody, FITC conjugated
    Biotin CSB-PA878084LD01HU SH3GLB1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability.
  • 基因功能參考文獻:
    1. Here the authors report that Endophilin B2, similarly to Endophilin B1, plays an indispensable role in mitochondria sequestration and inner mitochondrial membrane (IMM) protein degradation during mitophagy. PMID: 27112121
    2. endophilin B1 participates in dynamin 2-dependent formation of a population of transport vesicles distinct from those generated by A-type endophilins PMID: 27508440
    3. Bif-1 is involved in prostate cancer tumorigenesis and acts as a suppressor in prostate cancer progression. PMID: 27748942
    4. endophilin B1 mediated the biological function of EGFR in cancer cell proliferation through regulating the EGFR endocytic trafficking and downstream signaling. PMID: 27609472
    5. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy PMID: 25619828
    6. Our findings suggest that endophilin-B1 is a key mediator of a feed-forward mechanism of Alzheimer's disease pathogenesis PMID: 25981964
    7. Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5, Ambra1, beclin-1, LC3B and Bif-1 is significantly correlated with poor outcome. PMID: 23429496
    8. these data suggest a novel function for Bif-1 as a suppressor of breast cancer cell migration by promoting EGFR degradation through the regulation of endosome maturation PMID: 22785202
    9. The expression of Bif-1 is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1. PMID: 21283040
    10. These findings suggest that Bif-1 acts as a critical regulator of Atg9 puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation. PMID: 21068542
    11. GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagic response and cell death. PMID: 20159967
    12. Double knockdown of endophilin B1 and Drp1 leads to a mitochondrial phenotype identical to that of the Drp1 single knockdown, a result consistent with Drp1 acting upstream of endophilin B1 in the maintenance of morphological dynamics of mitochondria. PMID: 15452144
    13. Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis. PMID: 16227588
    14. BAR domain of endophilin-A1 drives membrane curvature by coordinate action of the crescent's scaffold mechanism and the ridge's membrane insertion in addition to membrane binding via amino-terminal amphipathic helix. PMID: 16763557
    15. The decreased expression of Bif-1 in malignant gastric epithelial cells compared with the normal mucosal cells suggests that loss of Bif-1 expression may play a role in gastric tumorigenesis, possibly by inhibiting the apoptosis mediated by Bif-1. PMID: 16916719
    16. Src phosphorylation of Bif-1 suppresses the interaction between Bif-1 and Bax, resulting in the inhibition of Bax activation during anoikis. PMID: 18474606
    17. Bif-1 expression might play a role in tumorigenesis in both urinary bladder (UB) and gallbladder (GB) cancer PMID: 18752120
    18. The loss of Bif-1 expression in a subset of prostate cancer samples is in agreement with the proapoptotic function of Bif-1. PMID: 18824435
    19. down-regulation of Bif-1 during the transition from normal colorectal mucosa to colorectal adenocarcinoma PMID: 18833585
    20. upregulation of Bif-1 could in part be responsible for tumorigenesis in cutaneous Merkel cell carcinoma PMID: 19125733
    21. Deregulation of Bif-1-related cell death is dependent not on Bif-1 mutation but on other mechanisms. PMID: 19132989
    22. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation PMID: 19805544

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane. Midbody.
  • 蛋白家族:
    Endophilin family
  • 組織特異性:
    Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 10833

    OMIM: 609287

    KEGG: hsa:51100

    UniGene: Hs.136309



主站蜘蛛池模板: 国产在线一卡2卡三卡4卡免费| 欧美日韩视频无码一区二区三| 青青草国产成人99久久| 奇米影视777四色狠狠| 色综合欧美亚洲国产| 成 人 网 站不卡在线观看| 亚洲综合伊人久久大杳蕉| 无码不卡av东京热毛片| 亚洲不乱码卡一卡二卡4卡5| 无码专区视频精品老司机| 久久一日本综合色鬼综合色| 中文字幕高清免费日韩视频在线| 成人精品一区二区三区中文字幕 | 人妻.中文字幕无码| 亚洲国产欧美在线人成| 国产精品无码人妻一区二区在线| 国产精品高清视亚洲中文| 尤物色综合欧美五月俺也去| 小嫩妇好紧好爽18禁视频| 18禁高潮出水呻吟娇喘蜜芽| 88久久精品无码一区二区毛片| 蜜桃av亚洲精品一区二区 | 免费无码不卡中文字幕在线| 国产女人天天春夜夜春| 午夜福利不卡片在线机免费视频| 国产老熟妇精品观看| 久久这里只精品国产免费10| 国产美足白丝榨精在线观看sm| 午夜福利视频一区二区手机免费看| 国产在热线精品视频| 亚洲一区精品无码| 日本公与熄乱理在线播放| 欧美老妇疯狂xxxxbbbb| 又色又爽又高潮免费视频观看 | 亚洲久久中文字幕www网站| 久久国产精品2020免费| 无码视频一区二区三区| 99这里只有精品| 137裸交肉体摄影| 天堂久久久久va久久久久| 亚洲色大成网站www国产|