在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SH2D2A Antibody

SH2D2A Antibody

  • 中文名稱：
    SH2D2A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003129
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using Lad Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    F2771 antibody; SCAP antibody; SH2 domain containing adapter protein antibody; SH2 domain containing protein 2A antibody; SH2 domain protein 2A antibody; SH2 domain-containing adapter protein antibody; SH2 domain-containing protein 2A antibody; SH22A_HUMAN antibody; Sh2d2a antibody; T cell specific adapter protein antibody; T cell specific adapter protein TSAd antibody; T cell specific adpater protein TSAd antibody; T cell-specific adapter protein antibody; T lymphocyte specific adaptor protein antibody; TSAd antibody; VEGF receptor associated protein antibody; VEGF receptor-associated protein antibody; VRAP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Lad.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides. PMID: 27896837
    2. TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells. PMID: 26163016
    3. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. PMID: 25492967
    4. Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues. PMID: 24910151
    5. in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene PMID: 21696499
    6. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements PMID: 20305788
    7. TSAd associates with laminin binding protein and mediates T lymphocyte migration during T cell activation PMID: 19561400
    8. 'short' alleles of the promoter could contribute to the genetic susceptibility to Juvenile Rheumatoid Arthritis PMID: 15129233
    9. TSAd appears to contribute to interleukin-2 synthesis at multiple different levels PMID: 15752554
    10. upon chemokine stimulation, Lad acts as an adaptor protein that links the G protein beta subunit to the tyrosine kinases Lck and Zap-70, thereby mediating T-cell migration PMID: 17327418
    11. SH2D2A expression is regulated both at the transcriptional and translational level. PMID: 18160104
    12. This study found a significant association between CIDP and the genotype GA13-16 homozygote (OR 3.167; p 0.013). PMID: 18533279
    13. lymphocyte-specific protein tyrosine kinase binds to T cell-specific adapter protein (TSAd) prolines and phosphorylates and interacts with the three C-terminal TSAd tyrosines PMID: 18541536
    14. the present study shows that the SH2D2A gene may contribute to susceptibility to MS. PMID: 18554728

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 組織特異性：
    Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, sma
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10821

    OMIM: 604514

    KEGG: hsa:9047

    STRING: 9606.ENSP00000376123

    UniGene: Hs.103527



主站蜘蛛池模板： 97伦伦午夜电影理伦片| 国产亚洲精品久久久久久禁果tv | 波多野结衣av高清一区二区三区| 久久久久久久久888 | 亚洲乱码日产精品bd在线| 亚洲第一狼人伊人av| 沈阳45老熟女高潮喷水亮点| 奇米精品视频一区二区三区| 无码av免费一区二区三区a片| 国产色情又大又粗又黄的电影| 精品乱子伦一区二区三区| 亚在线观看免费视频入口| 一本之道av不卡精品| 精品无码乱码av| 国产一区二区三区不卡av| 性按摩xxxx在线观看| 欧洲vat一区二区三区| 久久天天躁狠狠躁夜夜96流白浆 | 亚洲乱码一区二区三区在线观看 | 2018天天拍拍天天爽视频| 亚洲色婷婷久久精品av蜜桃久久 | 伊人成色综合网| 日本老妇人乱xxy| 国产v精品成人免费视频| 国产人成无码视频在线1000| 午夜性刺激免费看视频| 国产99视频精品免费视看9 | 9l国产精品久久久久麻豆| 久久综合给合久久狠狠97色| 国产佗精品一区二区三区| 欧美精品18videosex性欧美| 欧美最猛性xxxxx大叫| 欧美无人区码suv| 9l国产精品久久久久尤物| 天天碰免费上传视频| 国产精品人妻在线观看| 成人午夜福利视频镇东影视| 亚洲不乱码卡一卡二卡4卡5| 色综合a怡红院怡红院| 亚洲国产av精品一区二区蜜芽| 香港三级日本三级a视频|