在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SGTA Antibody

  • 中文名稱:
    SGTA兔多克隆抗體
  • 貨號:
    CSB-PA021204ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021204ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA021204ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SGTA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SGTA
  • 別名:
    Alpha SGT antibody; Alpha-SGT antibody; AlphaSGT antibody; hSGT antibody; SGT antibody; Sgt1 antibody; SGTA antibody; SGTA_HUMAN antibody; Small glutamine rich protein with tetratricopeptide repeats 1 antibody; Small glutamine rich tetratricopeptide repeat containing protein alpha antibody; Small glutamine rich tetratricopeptide repeat TPR containing alpha antibody; Small glutamine rich tetratricopeptide repeat-containing protein antibody; Small glutamine-rich tetratricopeptide repeat-containing protein alpha antibody; Stg antibody; UBP antibody; Vpu binding protein antibody; Vpu-binding protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Small glutamine-rich tetratricopeptide repeat-containing protein alpha protein (1-120AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity.; (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70.
  • 基因功能參考文獻:
    1. evidence that the interaction can mediate the association of Rpn13 and SGTA in a cellular context. PMID: 27827410
    2. Coimmunoprecipitation studies indicated that non-glycosylated tetherin is stabilized through the formation of a ternary SGTA/Vpu/tetherin complex. Although the results do not provide support for a physiological function of SGTA in HIV-1 replication, they demonstrate that SGTA overexpression regulates tetherin expression and stability, thus providing insights into the function of SGTA in endoplasmic reticulum translocation PMID: 27103333
    3. study demonstrates a critical role of Hsc70 in SV40 endoplasmic reticulum-to-cytosol penetration and reveal how SGTA controls Hsc70 to impact this process PMID: 28356524
    4. the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation. PMID: 26169395
    5. data suggest that SGTA regulates the cellular fate of a range of hydrophobic polypeptides should they become exposed to the cytosol. PMID: 25179605
    6. Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT). PMID: 25415308
    7. SGTA overexpression may be involved in the pathogenesis of breast cancer which might serve as a future target for novel treatment in breast cancer. PMID: 25027991
    8. Our data suggest a role for SGTA at distinct steps in the chaperone-dependent modulation of androgen, glucocorticoid, and progesterone receptor activity. PMID: 24753260
    9. SGTA depletion decreased cyclin A and cyclin B levels. PMID: 23839012
    10. A role of SGTA in Non-Hodgkin's lymphoma (NHL) cell proliferation, adhesion and drug resistance, and it may pave the way for a novel therapeutic approach for cell adhesion-mediated drug resistance in NHL. PMID: 24974147
    11. High expression of SGTA in esophageal squamous cell carcinoma correlates with proliferation and poor prognosis. PMID: 23939810
    12. Univariate analysis showed that the low SGTB expression was associated with poor prognosis (P<0.001) PMID: 24195513
    13. showed a significant increase in the AR:SGTA ratio in cancerous lesions compared to patient-matched benign prostatic hyperplasia tissue PMID: 23740762
    14. High Small glutamine-rich tetratricopeptide repeat-containing protein alpha expression is associated with non-small-cell lung cancer tumorigenesis. PMID: 23857189
    15. SGTA is present in human ovaries and has the potential to modulate androgen receptor signalling, but it may not be differentially expressed in polycystic ovary syndrome. PMID: 23433514
    16. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. PMID: 23246001
    17. Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface. PMID: 23142665
    18. Homodimerizaion of SGTA is dependent on the structural integrity of amino acids 1-80, and a core evolutionary conserved peptide within this region (amino acids 21-40) necessary for an effect of SGTA on the activity of the androgen receptor. PMID: 22693264
    19. A BAG6/SGTA cycle operates during protein maturation and quality control in the cytosol. PMID: 23129660
    20. findings show that the HERV-K(HML-2) Rec protein binds to hSGT and interferes with its role as a negative regulator of the androgen receptor (AR), resulting in enhanced AR activity PMID: 22733359
    21. small glutamine-rich protein/viral protein U-binding protein (SGT/UBP) is a cochaperone that negatively regulates Hsp70. PMID: 12482202
    22. interaction with the ubiquitin-dependent endocytosis motif of the growth hormone receptor PMID: 12735788
    23. Complete backbone assignments of the 121 residues of hSGT were determined and deposited in BMRB 5709. PMID: 12815268
    24. SGT is a new pro-apoptotic factor PMID: 15710426
    25. CSP modulates G protein function by preferentially targeting the inactive GDP-bound form of G alpha(s) and promoting GDP/GTP exchange; the guanine nucleotide exchange activity of full-length CSP is regulated by Hsc70-SGT PMID: 15972823
    26. the sub-cellular localization of SGT was closely associated with Hsp90beta and apoptosis PMID: 16580629
    27. Interaction of hSGT with Hsc70, Hsp70 or Bag-6/Bat-3/Scythe was demonstrated in prometaphase, thereby suggesting a possible role for complexes containing hSGT and distinct (co)-chaperones during mitosis. PMID: 16777091
    28. For SNP rs1640262, homozygotes for minor allele were protected against PCOS. Haplotype 1 (G-A-T) associated with increased risk of PCOS. In PCOS, haplotype 2 (A-G-C) associated with increased insulin resistance, resulting in increased insulin secretion. PMID: 18332089
    29. The recombinant human small glutamine-rich tetratricopeptide-repeat protein SGT has been purified and crystallized and preliminary analysis of the tetratricopeptide-repeat (TPR) domain is reported. PMID: 18607086
    30. The TPR domain of SGT can bind Vpu and reduce the amount of HIV-1 virus p24, which is the viral capsid, secreted from cells transfected with the HIV-1 proviral construct. PMID: 18759457
    31. SGTA acts as a rheostat of androgen receptor signaling in prostate cancer PMID: 17942943
    32. SGTA (or hSGT) is essential for cell division. Knock down experiments show that cells with reduced levels of SGTA arrest in mitosis and die while undergoing cell division. PMID: 14729056

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    SGT family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 10819

    OMIM: 603419

    KEGG: hsa:6449

    STRING: 9606.ENSP00000221566

    UniGene: Hs.203910



主站蜘蛛池模板: 精品国产一区二区三区av色诱| 九九视频在线观看视频6| 国产69精品久久久久久妇女迅雷 | 熟女少妇丰满一区二区| 亚洲一区二区三区写真| 国产成av人片在线观看天堂无码| 动漫成人无码精品一区二区三区 | av片日韩一区二区三区在线观看| 久久久久国产精品人妻aⅴ天堂| 国产免费人成视频在线播放播| 人澡人人澡人人澡欧美| 久久久久久久97| 四虎亚洲中文字幕无码永久 | 国产老熟女网站| 99国产在线精品视频| 97熟女毛毛多熟妇人妻aⅴ| 夜夜爽日日澡人人添| 久久精品人妻少妇一区二区三区 | 中文字幕人妻丝袜乱一区三区| 亚洲乱码中文字幕综合| 日本丰满护士bbw| 国产午夜福利精品一区| 国产成人av男人的天堂| 日日拍夜夜嗷嗷叫国产| 超碰国产天天做天天爽| 综合偷自拍亚洲乱中文字幕 | 久久久久成人精品无码| 成人国产三级在线观看| 一边做一边喷17p亚洲乱妇50p| 国产成人精品无码免费看| av怡红院一区二区三区| 无码人妻精品丰满熟妇区| 无码国产精品一区二区vr| 亚洲 欧美 国产 日韩 中文字幕| 国内精品久久久久影院嫩草| 国产精品嫩草99av在线| 欧美日韩在线视频一区| 欧美午夜精品久久久久久浪潮| 亚洲国产精品久久久天堂不卡海量 | 国产免费爽爽视频在线观看| 久久国产精品无码网站|