在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SGO1 Antibody, Biotin conjugated

  • 中文名稱:
    SGO1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA688764LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SGO1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SGO1
  • 別名:
    hSgo 1 antibody; hSgo1 antibody; NY BR 85 antibody; Serologically defined breast cancer antigen NY BR 85 antibody; Serologically defined breast cancer antigen NY-BR-85 antibody; SGO 1 antibody; SGO antibody; SGO L1 antibody; SGO1 antibody; SGOL 1 antibody; SGOL1 antibody; SGOL1_HUMAN antibody; Shugoshin 1AB protein antibody; Shugoshin 1CD protein antibody; Shugoshin 1EFprotein antibody; Shugoshin 1GH protein antibody; Shugoshin 1KL protein antibody; Shugoshin like 1 (S. pombe) antibody; Shugoshin like 1 antibody; Shugoshin-like 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Shugoshin 1 protein (260-439AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
  • 基因功能參考文獻:
    1. Aurora B kinase interacts with and phosphorylates Sgo1. Aurora B-mediated phosphorylation of Sgo1 regulates the distribution of Sgo1 between centromeres and chromosome arms. PMID: 25451264
    2. SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. PMID: 24146025
    3. Cohesin complex is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A recruitment. PMID: 26365192
    4. Sgo1 co-recruits Aurora B and PP2A to centromeres of unattached chromosomes. PMID: 25892238
    5. Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC). PMID: 25638162
    6. Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription. PMID: 26190260
    7. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. PMID: 25282101
    8. Bub1-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation. PMID: 24055156
    9. The most significant association with MaxDrinks was observed with SNP rs11128951 (p = 4.27 x 10(-8)) near SGOL1 gene at 3p24.3. PMID: 23953852
    10. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
    11. SGO1 promotes multidrug resistance of gastric cancer cells and may be useful as a novel therapeutic target for preventing or reversing multidrug resistance PMID: 23564482
    12. Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth PMID: 22161216
    13. These results suggest that SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability. PMID: 21532624
    14. HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres. PMID: 21346195
    15. Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export. PMID: 20384790
    16. Bub1 protects centromeric cohesion through Shugoshin in mitosis PMID: 15604152
    17. A shugoshin-like protein associates with centromeres during prophase and disappears at the onset of anaphase PMID: 15737064
    18. a specific subtype of serine/threonine protein phosphatase 2A (PP2A) associates with human shugoshin PMID: 16541025
    19. Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1. PMID: 16580887
    20. depletion of Sgo1 results in precocious chromosomal segregation and massive mitotic arrest PMID: 16628005
    21. Mutation in the SGOL1 D-box causes transient metaphase arrest, and leads to defects in chromosome alignment and segregation. PMID: 17448445
    22. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. PMID: 17617734
    23. Results suggest that NEK2A-mediated phosphorylation of Sgo1 (SGOL1) provides a link between centromeric cohesion and spindle microtubule attachment at the kinetochores. PMID: 17621308
    24. Centriole splitting induced by Sgo1 depletion or expression of a dominant negative mutant is suppressed by ectopic expression of sSgo1 or by Plk1 knockdown. PMID: 18331714
    25. findings suggest that hSgo1-downregulated colorectal cancers have a clinicopathological character of chromosome instability (CIN), and hSgo1 downregulation leads to CIN in colorectal cancer cells. PMID: 18635744
    26. the direct link between HP1 and shugoshin is conserved in human cells PMID: 18716626
    27. the spindle checkpoint kinase Bub1 contributes to the maintenance of Sgo1 steady-state protein levels in an APC/C-independent mechanism. PMID: 19015261
    28. Report structure and function of the PP2A-shugoshin interaction. PMID: 19716788
    29. A comprehensive review of Sgo1 function in eukaryote at meiosis and mitosis. PMID: 16112668

    顯示更多

    收起更多

  • 相關疾病:
    Chronic atrial and intestinal dysrhythmia (CAID)
  • 亞細胞定位:
    Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    Shugoshin family
  • 組織特異性:
    Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested.
  • 數據庫鏈接:

    HGNC: 25088

    OMIM: 609168

    KEGG: hsa:151648

    STRING: 9606.ENSP00000263753

    UniGene: Hs.105153



主站蜘蛛池模板: 日本理伦片午夜理伦片| 在线播放偷拍一区精品| 久久久久国色av免费观看| 欧美牲交a欧美牲交| 精品国产乱码久久久久夜深人妻| 激情综合色综合久久综合| 欧美成va视频网站| 国内精品久久人妻无码网站| 无码帝国www无码专区色综合| 99久久亚洲精品无码毛片 | 少妇私密推油呻吟在线播放| 亚洲日韩乱码一区二区三区四区| 精品无码久久久久久久久| 亚洲第一成年免费网站| 天堂а√中文在线| 18禁午夜宅男成年网站| 无码一区二区| 国产激情综合五月久久| 国产成人最新三级在线视频| 国产精品区一区二区三在线播放| 欧美丰满熟妇xxxx性ppx人交| 国产av综合影院| 国产国产久热这里只有精品| 国产精品久久久久久av福利| 国产av国片精品jk制服丝袜| 乱妇乱女熟妇熟女网站| 免费无码不卡中文字幕在线| 中文字幕有码无码人妻在线| 免费无遮挡无码视频在线观看| 久久精品中文字幕无码| 秋霞鲁丝无码一区二区三区| 骚虎成人免费99xx| 在线观看人成视频免费| 精品久久久久久无码专区不卡| 国产爆乳无码视频在线观看| 国产婷婷丁香五月缴情成人网| 国产精品成人精品久久久| 性裸交a片一区二区三区| 成人国产片视频在线观看| 无码抽搐高潮喷水流白浆| 久久精品国产亚洲7777|