在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SFRP5 Antibody

  • 中文名稱:
    SFRP5兔多克隆抗體
  • 貨號:
    CSB-PA830021
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA830021(SFRP5 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA830021(SFRP5 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    SFRP5 antibody; FRP1B antibody; SARP3 antibody; Secreted frizzled-related protein 5 antibody; sFRP-5 antibody; Frizzled-related protein 1b antibody; FRP-1b antibody; Secreted apoptosis-related protein 3 antibody; SARP-3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human SFRP5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
  • 基因功能參考文獻:
    1. results revealed the epigenetic silencing of SFRP5 by promoter methylation plays pivotal roles in chondrosarcoma development and metastasis through SFRP5/Wnt/beta-catenin signaling axis; modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of chondrosarcoma PMID: 30125549
    2. Sfrp5 may be an adipokine that is associated with the pathogenesis of Metabolic Syndrome in humans. PMID: 28303637
    3. Higher serum SFRP5 was inversely associated with multiple risk factors for type 2 diabetes and cardiovascular disease. PMID: 28851362
    4. This review article focuses on the effects of SFRP5 on the major systems of the body and on its association with the Wnt signaling pathways--{review} PMID: 25003224
    5. SFRP5 confers protection against oxidative stress-induced apoptosis through inhibition of beta-catenin activation and downregulation of Bax. PMID: 28834606
    6. serum concentration correlated with blood pressure in obese children and increased in response to lifestyle intervention PMID: 27882931
    7. The inverse association of serum Sfrp5 with beta-cell function suggests a detrimental role of Sfrp5 for insulin secretion also in humans. The severity of NAFLD does not appear to affect this relationship. The weak association between serum Sfrp5 and insulin sensitivity was partially explained by body mass. PMID: 27019073
    8. Results identify several coding and non-coding variants in the sFRP5 gene region, the majority of which resulted in a non-synonymous amino acid change in the protein. One of the variants (c.-3G[A) shows a trend towards association between the variant frequency and the obese phenotype. PMID: 27497818
    9. Results indicate that miR-125b can regulate SFRP5 expression and thus influence the growth and activation of cardiac fibroblasts. PMID: 27592695
    10. Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of gestational diabetes mellitus. PMID: 26100762
    11. Report reduced hepatic SFRP5 expression in morbidly women with NAFLD. PMID: 26256895
    12. Data suggest that serum SFRP5 levels are up-regulated in subjects with newly diagnosed type 2 diabetes as compared to prediabetic or control subjects; subjects were matched for obesity/overweight/body mass index. PMID: 25139699
    13. Sfrp5 represents a candidate for a mature adipocyte marker gene. PMID: 25324487
    14. The wnt5a/sFRP5 system is altered in human sepsis and might therefore be of interest for future studies on molecular pathophysiology of this common human disease. PMID: 25382802
    15. Serum SFRP5 is regulated by weight status and seems to be correlated with metabolic disorders in children. PMID: 24330025
    16. We were able to show a significant association of sFRP5 with both total abdominal and subcutaneous fat. The association signal was only seen in obese males in which the minor allele of rs7072751 explains 1.8 % of variance in total abdominal fat. PMID: 24287795
    17. SFRP5 and WNT5A comprise a balanced duo that may regulate metabolic homeostasis in prepubertal children. PMID: 24603290
    18. Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase. PMID: 24764263
    19. Serum SFRP5 levels significantly correlated with body mass index, the homeostasis model of assessment of insulin resistance, adiponectin levels, and CAD severity. Low SFRP5 levels may contribute to CAD. PMID: 24530778
    20. Therefore, cytokine release and insulin signaling were analyzed to investigate the impact of Sfrp5 on inflammation and insulin signaling in primary human adipocytes and skeletal muscle cells (hSkMC). PMID: 24465779
    21. SFRP5 gene methylation in leukemia cells activates Wnt/ss-catenin signaling to upregulate mdr1/P-gp expression and cause multidrug resistance. PMID: 24434572
    22. Wnt5a overproduction and SFRP5 deficiency in gastric mucosa may together play an important role in gastric inflammation and carcinogenesis. PMID: 24416340
    23. Epigenetic silencing of SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway PMID: 24374650
    24. Sfrp5 may play a role in the pathogenesis of T2 Diabetes mellitus. PMID: 23653377
    25. Plasma levels of SFRP5 were decreased in Chinese obese and T2DM subjects. SFRP5 was an independent factor affecting glucolipid metabolism, inflammation and insulin resistance. PMID: 23290274
    26. Patients with unmethylated SFRP5 are more likely to benefit from EGFR-TKI therapy. PMID: 23009178
    27. Circulating Sfrp5 is likely to play a major role in insulin resistance in humans. PMID: 23185036
    28. findings suggest that epithelium-derived SFRP5 may play a probable defensive role in impeding gastric cancer progression, characteristically by inhibiting GEC migration induced by macrophage-derived Wnt5a via JNK signaling activation PMID: 23054609
    29. Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects PMID: 22384249
    30. Promoter hypermethylation of SFRP5 is associated with Acute myeloid leukemia. PMID: 20795789
    31. data suggested that epigenetic silencing of SFRP5 leads to oncogenic activation of the Wnt pathway and contributes to ovarian cancer progression and chemoresistance through the TWIST-mediated EMT and AKT2 signaling PMID: 19957335
    32. The SFRP5 protein gene plays an important role in the pathogenesis of bladder tumor and can be detected using cellular DNA extracted from urine samples. PMID: 16609023
    33. In its role as tumor suppressor gene. SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management. PMID: 18356147
    34. Loss of SFRP5 is associated with oral squamous cell carcinoma PMID: 18497987
    35. SFRP5 promoter hypermethylation was significantly more frequent in microsatellite unstable colorectal neoplasms. PMID: 18795670
    36. In multiple myeloma cell lines, hypermethylation of SFRP5 was associated with transcriptional silencing. SFRP5 methylation was restricted to advanced MM stages & plasma-cell leukemia and may play a role in disease progression. PMID: 19299079
    37. SFRP5 is downregulated and inversely correlated with MMP-7 and MT1-MMP in gastric cancer PMID: 19586554

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Secreted frizzled-related protein (sFRP) family
  • 組織特異性:
    Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
  • 數據庫鏈接:

    HGNC: 10779

    OMIM: 604158

    KEGG: hsa:6425

    STRING: 9606.ENSP00000266066

    UniGene: Hs.279565



主站蜘蛛池模板: 久久99热人妻偷产国产| 男人下部进女人下部视频| 成 人影片 免费观看| 亚洲国产成人久久综合碰| 香港台湾经典三级a视频| 亚洲国产一区二区三区在观看| 麻豆视传媒精品av| 精品无人乱码高清| 男人狂躁进女人下面免费视频| 五月天中文字幕mv在线| 无码国产精品一区二区高潮| 中国女人和老外的毛片| 日韩无套内射视频6| 野花在线无码视频在线播放| 无码日日模日日碰夜夜爽| 大香伊人久久精品一区二区| 在办公室被c到呻吟的动态图| 好湿好紧太硬了我太爽了视频| 人妻无码中文字幕| 婷婷五月综合丁香在线| 熟妇人妻激情偷爽文| 成年午夜无码av片在线观看| 精品国产av色一区二区深夜久久| 四虎一区二区成人免费影院网址 | 欧美一道本一区二区三区| 四虎永久在线精品免费无码| 国产偷国产偷亚洲清高app | 久久久久国产精品人妻aⅴ果冻 | 国产成人理论无码电影网| 熟妇高潮精品一区二区三区| 少妇无码吹潮| 无码人妻aⅴ一区二区三区有奶水| 又黄又硬又湿又刺激视频免费 | 久久国产精品久久精品国产| 久久精品黄aa片一区二区三区| 婷婷久久香蕉五月综合| 国产无套水多在线观看| 狠狠色噜噜狠狠狠狠777米奇小说| 亚州av综合色区无码一区| 九九视频在线观看视频6| 成 人 免 费 黄 色|