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  4. SF3B6 Antibody

SF3B6 Antibody

  • 中文名稱：
    SF3B6兔多克隆抗體
  • 貨號：
    CSB-PA004047
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using SAP 14 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SF3B6
  • 別名：
    Ht006 antibody; P14 antibody; PM14_HUMAN antibody; Pre mRNA branch site protein p14 antibody; Pre-mRNA branch site protein p14 antibody; SAP14 antibody; SF3B 14 kDa subunit antibody; SF3B14 antibody; SF3B14a antibody; Splicing factor 3B, 14 kDa subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human SAP 14.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.
  • 基因功能參考文獻：
    1. the p14-RNA interaction screens charges on the backbone of the branch site during spliceosome assembly. PMID: 26784522
    2. determined the high resolution structure of a complex between SF3b14 and a peptide derived from SF3b155 and proposed a model for recognition of the pre-mRNA branch sequence adenosine. PMID: 16432215
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SF3B6 family
  • 數據庫鏈接：

    HGNC: 30096

    OMIM: 607835

    KEGG: hsa:51639

    STRING: 9606.ENSP00000233468

    UniGene: Hs.177861



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