在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SETD1A Antibody, Biotin conjugated

SETD1A Antibody, Biotin conjugated

  • 中文名稱：
    SETD1A兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA021101HD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SETD1A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SETD1A
  • 別名：
    Histone-lysine N-methyltransferase SETD1A antibody; hSET1A antibody; KMT2F antibody; Lysine N methyltransferase 2F antibody; Lysine N-methyltransferase 2F antibody; SET domain containing 1A antibody; SET domain containing protein 1A antibody; SET domain-containing protein 1A antibody; SET1 antibody; Set1 Ash2 histone methyltransferase complex subunit SET1 antibody; Set1/Ash2 histone methyltransferase complex subunit SET1 antibody; SET1A antibody; SET1A_HUMAN antibody; SETD1A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase SETD1A protein (188-304AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated.
  • 基因功能參考文獻(xiàn)：
    1. SETD1A contributes to retinoic acid -induced thrombomodulin expression in vascular endothelial cells by modulating the activity and expression of KLF4. PMID: 29940355
    2. Study showed that repressed HBV cccDNA chromatin state is activated by Set1A which mediates its activation by methylating H3K4. Also, Set1A was showed to be recruited to viral promoters in an HBx dependent manner. PMID: 27174370
    3. Rare loss-of-function variants in SETD1A are associated with Schizophrenia and Developmental disorders. SETD1A is the only gene implicated to date by whole-exome sequencing studies. PMID: 28969442
    4. data indicate that Setd1a and NURF complexes are specifically targeted to and coordinately regulate erythroid promoter chromatin dynamics during erythroid lineage differentiation PMID: 27141965
    5. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. PMID: 27563068
    6. Study provides evidence that increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates CREMA in systemic lupus erythematosus. PMID: 27904655
    7. the expression of hSETD1A occurs at a high rate in hepatocellular carcinoma patients. The expression state of hSETD1A may be a prognostic factor in hepatocellular carcinoma. PMID: 27656834
    8. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. PMID: 28229975
    9. Given the critical tumor suppressor role of p53, SETD1A-mediated suppression of this pathway (even in the absence of p53 mutations), would be predicted to have profound consequences on tumorigenesis. PMID: 26865005
    10. Findings provide evidence that SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically. PMID: 26581161
    11. Loss-of-function variants in SETD1A cause a range of neurodevelopmental disorders in a Finnish population. PMID: 26974950
    12. Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors PMID: 26691508
    13. This study demonstrated that SETD1A mutation showing the highest statistical significance in Autism and Schizophrenia. PMID: 26938441
    14. suppresses BTG2 expression through its induction of several BTG2-targeting miRNAs PMID: 26394836
    15. Set1/MLL complex is indispensable for the transcriptional ability of HSF2. PMID: 26478434
    16. Study reveals that SETD1A controls tumor metastasis by activating matrix metalloproteinases (MMP) expression and provides an epigenetic link among SETD1A, MMPs, and metastasis of breast cancer. PMID: 25373480
    17. Co-immunoprecipitation demonstrated LANA association with endogenous hSET1 complexes in both lymphoid and endothelial cells suggesting that LANA may contribute to the epigenetic profile of KSHV episomes PMID: 25033463
    18. Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS PMID: 25542209
    19. these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo. PMID: 25561738
    20. This study demonistrated that Loss-of-function variants of loss of function variants of SETD1A is a canadate susceptibility of Schizophrenia. PMID: 24853937
    21. hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells. PMID: 24247718
    22. These results demonstrate that the increase of H3K4me3 by human Set1 complex is involved in activation of lytic genes during the lytic infection of KSHV. PMID: 23306522
    23. A synergistic role of hSET1 and NURF in regulating the USF-bound barrier insulator to prevent erythroid genes from encroachment of heterochromatin. PMID: 21653943
    24. HCF-1 was required for recruitment of the histone methyltransferases Set1 and MLL1, leading to histone H3K4 trimethylation and transcriptional activation. PMID: 17578910
    25. suggest a model for how the mammalian RNA polymerase II machinery is linked with histone H3-Lys4 histone methyltransferase complexes at transcriptionally active genes PMID: 17998332
    26. Data show that Wdr82, which associates with chromatin in a histone H2B ubiquitination-dependent manner, is a specific component of Set1 complexes but not that of MLL1-4 complexes. PMID: 18838538

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29010

    OMIM: 611052

    KEGG: hsa:9739

    STRING: 9606.ENSP00000262519

    UniGene: Hs.297483



主站蜘蛛池模板： 激情综合色综合啪啪五月丁香| 2021国产精品成人免费视频| 欧美毛多水多肥妇| 亚洲熟妇无码av不卡在线播放| 中文字幕制服丝袜第57页| 日日碰狠狠添天天爽无码| 欧美人与动牲交xxxxbbbb| 国产成人影院一区二区三区| 无遮挡18禁啪啪免费观看| 亚洲一区二区三区四区五区六区| 欧美性插b在线视频网站| 亚洲国产欧美在线人成大黄瓜| 中文字幕无码中文字幕有码a| 女人脱了内裤趴开腿让男躁| 亚洲伊人色欲综合网| 一本一道av中文字幕无码| 国内自拍久久久久影院| 18禁止看的免费污网站| 亚洲熟妇无码八av在线播放| 97久久婷婷五月综合色d啪蜜芽| 亚洲国产色播av在线| 欧美乱大交xxxxx潮喷l头像 | 国产肉体xxxx裸体137大胆| 2020年国产精品| 中国白嫩丰满人妻videos | 丝袜老师办公室里做好紧好爽| 亚洲日韩穿丝袜在线推荐| 国产成人无码午夜视频在线播放 | 久久精品国产精油按摩| av一区二区国产在线视频| 成人免费国产精品视频| 国内精品久久久久久久影视| 狼友网精品视频在线观看| 日日夜夜撸啊撸| 男人的天堂av网站| 97人妻免费碰视频碰免| 亚洲精品国偷拍自产在线麻豆| 女人与拘性猛交视频| 2019久久视频这里有精品15| 色欲综合久久躁天天躁| 99久久无码一区人妻|