在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SESN1 Antibody, Biotin conjugated

SESN1 Antibody, Biotin conjugated

  • 中文名稱：
    SESN1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA021095LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SESN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    1110002G11Rik antibody; AU044290 antibody; MGC118148 antibody; MGC138241 antibody; MGC142129 antibody; OTTMUSP00000022799 antibody; p53 activated gene 26 antibody; p53 regulated PA26 nuclear protein antibody; p53 regulated protein PA26 antibody; p53-regulated protein PA26 antibody; PA26 antibody; RP11-787I22.1 antibody; sesn1 antibody; SESN1_HUMAN antibody; SEST1 antibody; sestrin 1 antibody; Sestrin-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sestrin-1 protein (224-337AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
  • 基因功能參考文獻(xiàn)：
    1. Study shows that SESN1 mRNA, UHRF1BP11 mRNA and miRNA-377-3p levels are prognostically relevant in human papillomavirus-negative head and neck squamous cell carcinoma patients. PMID: 28886272
    2. The antitumor efficacy of pharmacological EZH2 inhibition depends on SESTRIN1, indicating that mTORC1 control is a critical function of EZH2 in lymphoma. PMID: 28659443
    3. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR) of affinity purified sesn1 and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 and sesn2 have a predominant a-helical structure. PMID: 28707664
    4. this study shows that sestrin1 genetic ablation results in broad reconstitution of immune function in stressed T cells and enhanced vaccine responsiveness in old mice PMID: 28114291
    5. Rapamycin may prohibit sestrin1 downregulation through targeting mTORC2 in appeasing low shear stress induced EC oxidative apoptosis PMID: 24587596
    6. PA26 mutations are an infrequent cause of heterotaxia (situs inversus) in humans. PMID: 12607115
    7. results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H PMID: 15105503

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Sestrin family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21595

    OMIM: 606103

    KEGG: hsa:27244

    STRING: 9606.ENSP00000393762

    UniGene: Hs.591336



主站蜘蛛池模板： 中文天堂在线www| 俺去俺来也www色官网| 色老头在线一区二区三区| 国产成人亚洲精品无码h在线| 国产精品成人永久在线四虎| 成人片黄网站a毛片免费观看| 中文字幕韩国三级理论| 无码人妻一区二区三区在线| 免费人成年激情视频在线观看 | 精品国产自在现线电影| 成人福利国产精品视频| 国产精品v片在线观看不卡| 日韩中文字幕在线一区二区三区| 青草青草久热国产精品| 国产精品aⅴ视频在线播放| 在教室伦流澡到高潮hgl视频| 久久精品亚洲日本波多野结衣| 2020最新国产在线不卡a| 精品综合久久久久久97| 真实国产乱啪福利露脸| 国产精品福利自产拍在线观看| 无码av岛国片在线播放| 精品麻豆丝袜高跟鞋av| 欧洲 亚洲 国产图片综合| 久久国产人妻一区二区| 免费看成人aa片无码视频羞羞网| 狠狠色丁香久久婷婷综合五月| 欧美综合自拍亚洲综合区| 欧美自拍另类欧美综合图片区| 波多野吉衣av无码| 欧美黑人又粗又硬xxxxx喷水| 亚洲日韩一中文字暮av| 亚洲人成电影网站色www| 法国啄木乌av片在线播放| 国偷自产一区二区三区在线视频| 中文字幕精品一区二区2021年| 国语对白做受xxxxx在线中国| 成年轻人电影免费无码| 农村乱人伦一区二区| 成品人视频ww入口| 日本少妇高潮喷水免费可以看|