在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SERPINB7 Antibody

  • 中文名稱:
    SERPINB7兔多克隆抗體
  • 貨號:
    CSB-PA070133
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SERPINB7
  • 別名:
    Megsin antibody; Mesangium predominant gene megsin antibody; MGC120014 antibody; MGC120015 antibody; Serpin B7 antibody; Serpin peptidase inhibitor clade B (ovalbumin) member 7 antibody; Serpinb7 antibody; SPB7_HUMAN antibody; TP55 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Megsin.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
  • 基因功能參考文獻:
    1. SERPINB7 mutations are related strictly to the PPKN phenotype. Our study indicates that screening for SERPINB7 mutations is useful to distinguish PPKN from other PPK types and from non-PPK keratinizing diseases with palmoplantar skin lesions. PMID: 28211129
    2. Direct sequencing of SERPINB7 revealed five homozygous founder mutations (c.796C>T) and four compound heterozygous mutations in nine patients, including one novel mutation (c.122_127delTGGTCC). PMID: 27666198
    3. Case Report: striate palmoplantar keratoderma showing transgrediens in a patient with heterozygote nonsense mutations in DSG1 and SERPINB7. PMID: 27786350
    4. Results show splice variants from the two recurrent splice-site mutations in SERPINB7, provide evidence for the pathogenicity of the mutations and suggest an in-frame deletion of exon 3 may cause NPPK and that the CD-loop could affect SERPINB7 function PMID: 25940237
    5. These results indicate that megsin gene variants may play a role in the severity, development, and/or progression of IgAN in Northwest Chinese population PMID: 26871801
    6. Recessive missense mutation of SERPINB7 gene was found in Japanese families diagnosed with palmoplantar keratosis. PMID: 26763456
    7. Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population PMID: 25007157
    8. These data clearly provide further evidence that NPPK is caused by loss-of-function mutations in SERPINB7. PMID: 24773080
    9. megsin 2093C/T C allele may be genetic marker for IgA nephropathy susceptibility [review] PMID: 24575807
    10. The mean concentration of serpin B7 at 28-32 weeks was 1.5-fold higher in women with subsequent preterm deliveries compared to controls. PMID: 24954659
    11. study reports on seven unrelated Chinese patients with Nagashima-Type Palmoplantar Keratosis with four underlying SERPINB7 mutations, of which one is a recurrent variant (c.796C>T) PMID: 24514002
    12. All of the identified mutants are predicted to cause premature termination upstream of the reactive site, which inhibits the proteases, suggesting a complete loss of the protease inhibitory activity of SERPINB7 in palmoplantar keratosis skin. PMID: 24207119
    13. A267G in 5'-untranslated region within the exon of megsin may be one of the substantial genetic basis for differentiating "deficiency of liver yin and kidney yin" syndrome and "deficiency of qi and yin" syndrome in primary immunoglobulin A nephropathy. PMID: 18471408
    14. Mesangial cell-predominant gene, megsin. Genetic manipulation of megsin engenders two elementary mesangial lesions, mesangial expansion and an increase in the number of mesangial cells. PMID: 12386281
    15. One positive regulatory motif, an incomplete activator protein-1 binding motif (CTGATTCAC) within the -120 to -112 region. This cis-acting element in the 5'-flanking region of megsin is involved in the activation of the megsin gene in mesangial cells. PMID: 12397041
    16. Megsin has a role in susceptibility to immunoglobulin A nephropathy PMID: 15213261
    17. in transgenic rats, overexpression of human megsin, a recently discovered serpin located in the kidney, produces renal and pancreatic lesions characteristic of serpinopathies PMID: 15788472
    18. In this Chinese population, the 2093C-2180T haplotype at the 3'UTR of MEGSIN gene is associated with more severe forms of IgA nephropathy, and more rapid disease progression PMID: 16431886
    19. The polymorphism of megsin A23167G is associated with susceptibility and progression of IgA nephropathy in Chinese population. GG genotype is associated with severe histological lesions and progression of the disease. PMID: 16550745
    20. study found out that the megsin TT haplotype (defined as T-2093, T-2180 alleles) could play a protective role in the progression of IgA nephropathy PMID: 18498720
    21. recombinant megsin did not affect the mRNA expressions of TGF- and PAI-1, and did not modify the enzymatic activity of PAI-1 PMID: 18580857
    22. Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients. PMID: 18793525

    顯示更多

    收起更多

  • 相關疾病:
    Keratoderma, palmoplantar, Nagashima type (PPKN)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Serpin family, Ov-serpin subfamily
  • 組織特異性:
    Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body.
  • 數據庫鏈接:

    HGNC: 13902

    OMIM: 603357

    KEGG: hsa:8710

    STRING: 9606.ENSP00000337212

    UniGene: Hs.138202



主站蜘蛛池模板: 久热中文字幕无码视频| 成人3d动漫一区二区三区| 国产一区丝袜在线播放| 日韩人妻无码精品专区综合网| 女厕厕露p撒尿八个少妇| 成人影片一区免费观看| 鲁丝片一区二区三区毛片| 欧美人与动zozo在线播放| 亚洲成a人片在线观看日本| 久久99亚洲精品久久99果| 99精品国产兔费观看久久| 丰满少妇被粗大猛烈进人高清| 国产精品无码午夜免费影院| 扒开双腿疯狂进出爽爽爽| 国内揄拍国内精品人妻| 亚洲中文无码永久免| 无码人妻丰满熟妇区bbbbxxxx| 亚洲 自拍 另类 欧美 综合| 忍着娇喘人妻被中出中文字幕| 国产成人8x人网站视频在线观看| 国产精品福利视频导航| 国语国产精精品国产国语清晰对话| 无码h黄动漫在线播放网站 | 性亚洲videofree高清| 亚洲综合另类小说色区一| 久久婷婷激情综合色综合俺也去| 欧美国产伦久久久久久久| 国产公开免费人成视频| 少妇太爽了在线观看免费视频| 在线亚洲精品国产一区麻豆| h人成在线看免费视频| 亚洲精品nv久久久久久久久久| 成人性生交大片免费| 国产精品国产午夜免费看福利| 精品一卡2卡三卡4卡免费网站| 无码av波多野结衣| 国产成人a区在线观看| 国产成人av在线免播放观看| 亚洲18禁私人影院| 九九九国产精品成人免费视频| 久久国产午夜精品理论片34页|