在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SERPINA5 Antibody

SERPINA5 Antibody

  • 中文名稱：
    SERPINA5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA561778
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells, using Serpin A5 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SERPINA5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human Serpin A5.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類(lèi)型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
  • 基因功能參考文獻(xiàn)：
    1. the snp rs1955656 in the SERPINA5 were associated with the development of severe acute kidney injury (KDIGO stage 2-3) in critically ill patients with septic shock PMID: 28270177
    2. Data show that the methylation degree of five CpG sites significantly correlated with lower SERPINA5 expression levels. PMID: 29187436
    3. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer PMID: 27207655
    4. host protein C inhibitor expressed in mouse has a role in inhibiting tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability PMID: 25887633
    5. These findings highlight an important role of SERPINA5 in the regulation of migratory and metastatic potentials of HCC and suggest a potential application of SERPINA5 in cancer treatment. PMID: 24388360
    6. These results suggest that HIV resistance in some exposed patients is the result of a balance between downregulation of serine proteinases and upregulation of their inhibitors. PMID: 24928035
    7. A novel protein C inhibitor gene mutation in pediatric stroke patients after bone marrow transplantation. PMID: 23670045
    8. Decreased SERPINA5 expression due to DNA promoter methylation is associated with papillary thyroid carcinoma. PMID: 24222120
    9. the SERPINA5 gene, which codes for the protein C inhibitor involved in many biological processes including inflammation, may be a new susceptibility locus for PTC. PMID: 23520464
    10. One of the monomers, 52-kDa PCI, formed a stable complex with activated protein C, urokinase, plasma and tissue kallikrein, but the dimer species and 48-kDa PCI were inactive. PMID: 22206708
    11. the effects of N-glycans and the NH-terminus on a PCI function PMID: 22205989
    12. SerpinA5 expression is significantly reduced in advanced-stage serous borderline tumors and serous carcinomas. PMID: 21102419
    13. This study was undertaken to further understand the structural micro-heterogeneity of PCI. Individuals of two different ethnicities possess a similar PCI pattern, verifying that the micro-heterogeneity is conserved among humans. PMID: 21056543
    14. APC-PCI complex levels were higher in peripheral arterial disease patients than in controls, but did not predict the clinical outcome. PMID: 20409682
    15. function for PCI in innate immunity PMID: 20019810
    16. In men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0). PMID: 19765701
    17. PCI can up regulate TAFI activation by inhibiting the protein C activation. PCI may therefore be an important regulator in the balance between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of protein C. PMID: 11686324
    18. Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor. PMID: 11864713
    19. Protein C inhibitor regulates the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by these cells PMID: 14696115
    20. PCI may be involved in regulating key serine proteases involved in metastatic prostate disease PMID: 15878512
    21. exposure of oxidized PE and/or PS may be important for the local regulation of protein C inhibitor activity in vivo PMID: 17332248
    22. anti-angiogenic activity of PCI was strong as cleaved antithrombin, and slightly stronger than that of plasminogen activator inhibitor-1 and pigment epithelium-derived factor PMID: 17450526
    23. Patients with abdominal aortic aneurysm have increased thrombin generation reflected by an increase in the activated protein C-protein C inhibitor complex, which correlates with aneurysm size. PMID: 18184931
    24. In human renal tissues, PCI and urinary plasminogen activator colocalized in the cytoplasm of renal proximal tubular epithelial cells PMID: 18193533
    25. A crystallographic structure of the Michaelis complex of PCI, thrombin, and heparin to 1.6 A resolution, was determined. PMID: 18362344
    26. The heparin binding site of protein C inhibitor is protease-dependent. PMID: 18974053

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted, extracellular space. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8723

    OMIM: 601841

    KEGG: hsa:5104

    STRING: 9606.ENSP00000333203

    UniGene: Hs.159628



主站蜘蛛池模板： 国产白嫩漂亮美女在线观看 | 在线观看肉片av网站免费| 成人免费一区二区三区| 成人麻豆日韩在无码视频| 国产精品女同一区二区在线| 做性久久久久久| 免费床视频大全叫不停欧美| 久久久精品国产免大香伊| 无码人妻一区二区三区一| 国产三级韩国三级日产三级| 日本久久综合久久鬼色| 99re6这里有精品热视频| 国产av成人一区二区三区| 精产国品一区二区三产区| 国产一区二区亚洲精品 | 亚洲国产午夜精品理论片| 92午夜少妇极品福利无码电影| 8x国产精品视频| 久久99国产亚洲高清观看首页| 99国产精品久久久蜜芽| 国产精品久久久久9999不卡| 午夜无码人妻av大片色欲| 播放男人添女人下边视频| 九九热线有精品视频| 尤物tv国产精品看片在线| 国产av一区二区三区日韩| 99精品国产兔费观看久久99| 国产情侣草莓视频在线| 人人妻人人超人人| 五月天中文字幕mv在线| 99热久久这里只有精品| 午夜福利啪啪无遮挡免费| 久久久国产乱子伦精品| 激情综合色五月丁香六月亚洲| 色综合天天综合网中文| 热99re久久国超精品首页| 亚洲综合久久一区二区| 人妻少妇av无码一区二区| 东京热加勒比视频一区| 中文字幕av一区二区三区| 久久精品久久电影免费理论片|