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  4. SERP1 Antibody

SERP1 Antibody

  • 中文名稱：
    SERP1兔多克隆抗體
  • 貨號：
    CSB-PA237602
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA237602(SERP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA237602(SERP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SERP1
  • 別名：
    D3Ucla1 antibody; Ramp4 antibody; Ribosome associated membrane protein 4 antibody; Ribosome attached membrane protein 4 antibody; Ribosome-attached membrane protein 4 antibody; Serp1 antibody; SERP1_HUMAN antibody; Stress associated endoplasmic reticulum protein 1 antibody; Stress-associated endoplasmic reticulum protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human SERP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
  • 基因功能參考文獻：
    1. Study demonstrated that SERP1 expression level was significantly upregulated in human pancreatic ductal adenocarcinoma (PDAC) tissues which positively associated with advanced clinical stage and shorter survival time (OS and DFS). Downregulated SERP1 expression promoted PDAC cell apoptosis and inhibited NF-kappaB activation probably by upregulating SRPRB expression. PMID: 28902358
    2. expression of SFRP1 mRNA and protein correlates with the Gleason score, survival rate and response for endocrine therapy of prostate cancer. PMID: 25719802
    3. SFRP1 DNA methylation, accumulates with age in normal-appearing kidney tissues and is associated with increased renal cancer risk. PMID: 22419128
    4. SERP1 is a novel cochaperone and regulator of ENaC expression. PMID: 22526458
  • 亞細胞定位：
    Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
  • 蛋白家族：
    RAMP4 family
  • 數據庫鏈接：

    HGNC: 10759

    OMIM: 617674

    KEGG: hsa:27230

    STRING: 9606.ENSP00000239944

    UniGene: Hs.518326



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