在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEPT9 Antibody

  • 中文名稱:
    SEPT9兔多克隆抗體
  • 貨號:
    CSB-PA286864
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA286864(SEPT9 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA286864(SEPT9 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SEPT9
  • 別名:
    AF17q25 antibody; Cell division control protein septin D1 antibody; KIAA0991 antibody; MLL septin like fusion protein antibody; MLL septin-like fusion protein antibody; MLL septin-like fusion protein MSF-A antibody; MSF antibody; MSF1 antibody; NAPB antibody; Ov/Br septin antibody; Ovarian/breast septin alpha antibody; Ovarian/Breast septin antibody; PNUTL4 antibody; SEPT9 antibody; SEPT9_HUMAN antibody; SeptD1 antibody; Septin 9 antibody; Septin D1 antibody; Septin-9 antibody; SINT1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human SEPT9
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
  • 基因功能參考文獻:
    1. Thus our data indicate that Sept9_i2 is a negative regulator of breast tumorigenesis. We propose that Sept9 tumorigenic properties depend on the balance between Sept9_i1 and Sept9_i2 expression levels. PMID: 28338090
    2. The plasma levels of septin-9 and clusterin in ovarian cancer patients were abnormally elevated, which might be used as potential candidates of peripheral blood tumor biomarkers for early diagnosis of EOC and septin-9 might be related to distal metastases of EOC. PMID: 29970704
    3. The primary aim of this study was to evaluate the diagnostic accuracy of a PCR-based assay for the analysis of SEPT9 promoter methylation in circulating cell-free DNA (mSEPT9) for diagnosing hepatocellular carcinoma. PMID: 29627389
    4. Septin 9 regulates lipid droplet growth through binding to phosphatidylinositol-5-phosphate in Hepatitis C virus infected cells.Septin 9 regulates lipid droplets growth and perinuclear accumulation in a manner dependent on dynamic microtubules.Septin 9 regulates Hepatitis C virus replication. PMID: 27417143
    5. The SEPT9 assay exhibited satisfactory performance in colorectal cancer diagnosis and screening, while more evidence is needed for therapeutic effect monitoring and prognosis prediction. PMID: 28128742
    6. Studies indicate that methylated Septin 9 ((m)SEPT9) can be consistently detected in plasma samples derived from whole blood samples collected with S-Monovette(R) K3E and BD Vacutainer (R) K2EDTA tubes stored at 2-8 degrees C for a maximum of 24 h and for samples collected in S-Monovette CPDA tubes stored at 18-25 degrees C for up to 48 h. PMID: 27753040
    7. our study has validated a new SEPT9 assay and combined testing as an aid in cancer detection, providing a new approach for opportunistic CRC screening. PMID: 27133379
    8. Study shows a stepwise increase of SEPT9 methylation from non-cancerous to cancerous tissue in colorectal adenocarcinoma. PMID: 27660666
    9. Study found SHOX2 and SEPT9 frequently methylated in biliary tract cancers. PMID: 27999621
    10. These results indicate that SEPT9_v2 promoter hypermethylation, which silences the expression of SEPT9_v2 mRNA, is observed in a significant proportion of breast tumors, and that methylated SEPT9_v2 may serve as a novel tumor marker for breast cancer. PMID: 27499429
    11. The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 modulates the interactions of KIF17 with membrane cargo. PMID: 26823018
    12. SEPT9 promoter methylation and MN frequency, both measured in peripheral blood, occur at an early stage compared to carcinoma development, indicating that the approach might be suitable to monitor CRC development. PMID: 26633373
    13. KRAS mutations and SEPT9 promoter methylation were present in 34% (29/85) and in 82% (70/85) of primary tumor tissue samples. PMID: 25946211
    14. SEPT9_i1 is expressed in high-grade prostate tumors suggesting it has a significant role in prostate tumorigenesis. PMID: 25898316
    15. we demonstrate that SEPT9 negatively regulates EGFR degradation by preventing the association of the ubiquitin ligase Cbl with CIN85, resulting in reduced EGFR ubiquitylation PMID: 25472714
    16. provide a full overview of the theoretical basis, development, validation, and clinical applications of the SEPT9 assay for both basic science researchers and clinical practitioners PMID: 26471083
    17. Results show that in plasma samples, elevated methylated SEPT9 (mSEPT9) values were detected in colorectal cancer, but not in adenomas. Tissue levels of mSEPT9 alone are not sufficient to predict mSEPT9 levels in plasma. PMID: 25526039
    18. Authors report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion. PMID: 25293760
    19. Our results suggest that SEPT9 gene methylation is a valuable biomarker for screening CRC in the Chinese population PMID: 24535900
    20. SEPT9 promoter methylation is detected in free circulating DNA of lung cancer patients PMID: 24633736
    21. The study shows increased SEPT9 expression as a consequence of genomic amplification and is the first study to profile SEPT9_v1 through SEPT9_v7 isoform-specific mRNA expression in tumor and nontumor tissues from patients with breast cancer. PMID: 24127542
    22. prognostic value of SHOX2 and SEPT9 DNA methylation in benign, paramalignant and malignant pleural effusions PMID: 24386354
    23. epigenetic deregulation of SEPT9 plays a role in the development of colorectal cancer. Aberrant hypermethylation of this gene occurs only in one of its CpG islands and this hypermethylation likely is an early event in the adenoma-carcinoma sequence. PMID: 23988185
    24. SEPT9 repeat motifs bind and bundle MTs, and thereby promote asymmetric neurite growth. PMID: 24344182
    25. SEPT9 isoform 1 is required for the association between HIF-1alpha and importin-alpha to promote efficient nuclear translocation. PMID: 24067372
    26. SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9. PMID: 23572511
    27. Serum methylation levels of TAC1, SEPT9, and EYA4 were significant discriminants between stage I colorectal cancer and healthy controls. PMID: 23862763
    28. SEPT9 plays multiple roles in abscission, one of which is regulated by the action of Cdk1 and Pin1. PMID: 23990466
    29. The identification of a SEPT9 mutation in a neonate with respiratory distress due to vocal cord paralysis expands the differential diagnosis in these patients. PMID: 22981636
    30. Matrix stiffness regulates endothelial cell proliferation through septin 9 PMID: 23118862
    31. SEPT9 in plasma has a role in both left- and right-sided colon cancers PMID: 23049919
    32. Myeloid K562 cells express three SEPT9 isoforms, all of which have an equal propensity to hetero-oligomerize with SEPT7-containing hexamers to generate octameric heteromers. PMID: 22956766
    33. SEPT9_v4 expression may be clinically relevant and contribute to some forms of drug resistance. PMID: 22278362
    34. SEPT9 gene amplification and overexpression during human breast tumorigenesis PMID: 21831286
    35. Data illustrated roles of SEPT9 that might contribute to hetero-trimeric septin complex formation. SEPT9 can substitute for septins of the SEPT2 group and partially for SEPT7. PMID: 21767235
    36. SEPT9 holds a terminal position in the septin octamers, mediating abscission-specific polymerization during cytokinesis. PMID: 22123865
    37. uneven distribution of SEPT9 among core septin heteromers causes heterogeneity with respect to both subunit number and polymerization interfaces PMID: 21737677
    38. Increased methylation of septin 9 resulting in decreased mRNA and protein expression is associated with colorectal cancer. PMID: 21267688
    39. Data demonstrate that SEPT9 mediates the localization of the vesicle-tethering exocyst complex to the midbody, providing mechanistic insight into the role of SEPT9 during cell division. PMID: 21059847
    40. A total of seven heterogeneous SEPT9 duplications have been identified in this study as a causative factor of hereditary neuralgic amyotrophy. PMID: 19939853
    41. New insights and validation are provided for applying SEPT9 transcript variant 1 as a potential target for antitumor therapy via interruption of the HIF-1 pathway. PMID: 20407014
    42. Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. PMID: 20140221
    43. Case represents an additional MLL-SEPT9-positive AML that was considered to be related to therapy. RT-PCR and sequencing analyses demonstrated MLL-SEPT9 fusion transcripts with the breakpoint of MLL exon 8/SEPT9 exon 2 and MLL exon 9/SEPT9 exon 2. PMID: 20682395
    44. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    45. Coexistence of alternative MLL-SEPT9 fusion transcripts in an acute myeloid leukemia with t(11;17)(q23;q25). PMID: 20113838
    46. Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25). PMID: 12095151
    47. These results reveal that MSF is required for the completion of cytokinesis and suggest a role that is distinct from that of Nedd5. PMID: 12388755
    48. Filament formation of MSF-A, a mammalian septin, in human mammary epithelial cells depends on interactions with microtubules PMID: 12626509
    49. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption PMID: 15485874
    50. overexpression of SEPT9 in neoplasia is not simply a proliferation-associated phenomenon, despite its role in cytokines PMID: 15782116

    顯示更多

    收起更多

  • 相關疾病:
    Hereditary neuralgic amyotrophy (HNA)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
  • 蛋白家族:
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
  • 組織特異性:
    Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expres
  • 數據庫鏈接:

    HGNC: 7323

    OMIM: 162100

    KEGG: hsa:10801

    STRING: 9606.ENSP00000391249

    UniGene: Hs.440932



主站蜘蛛池模板: 男女做爰猛烈啪啪吃奶动| 国产精品久久久久久亚洲影视| 天堂а√中文最新版在线| 亚洲人成电影网站色| 亚洲欧美日韩国产另类电影| 日本免费一区二区三区四区五区 | 乱人伦中文视频在线| 免费情侣作爱视频| 国产午夜无码片在线观看网站| 柠檬福利第一导航在线| 亚洲国产精品久久久久秋霞影院 | 欧美老人巨大xxxx做受视频| av无码东京热亚洲男人的天堂| 色欲来吧来吧天天综合网| 手机国产乱子伦精品视频| 欧美精品亚洲精品日韩传电影| 人人模人人爽人人喊久久| 少妇无码精油按摩专区| 中文字幕亚洲欧美在线不卡| 免费无码国产v片在线观看| 人人狠狠综合久久88成人| 亚洲日韩精品无码专区加勒比海| 女人被狂c躁到高潮视频| 国产亚洲精品久久久久久久软件| 丝袜老师高潮呻吟高潮| 亚洲成av人片在线观看不卡| 人妻夜夜爽天天爽三区丁香花| 超碰国产精品人人做人人爱| 亚洲人成电影综合网站色www| 国产又粗又猛又黄又爽无遮挡| 伊人蕉久中文字幕无码专区| 国内精品免费久久久久软件| 69国产成人精品午夜福中文| 特黄aaaaaaaaa毛片免费视频| 法国白嫩大屁股xxxx| 波多老师无码av中字专区| 日本高清视频wwww色| 国产看真人毛片爱做a片| 国产福利姬喷水福利在线观看| 日韩乱码人妻无码中文视频| 丰满爆乳一区二区三区|