在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SENP2 Antibody, HRP conjugated

  • 中文名稱:
    SENP2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA888026LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SENP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Axam2 antibody; DKFZp762A2316 antibody; KIAA1331 antibody; Senp2 antibody; SENP2_HUMAN antibody; Sentrin specific protease 2 antibody; Sentrin-specific protease 2 antibody; Sentrin/SUMO specific protease SENP2 antibody; Sentrin/SUMO-specific protease SENP2 antibody; SMT3 specific isopeptidase 2 antibody; SMT3-specific isopeptidase 2 antibody; Smt3ip2 antibody; SUMO1/sentrin/SMT3 specific peptidase 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sentrin-specific protease 2 protein (138-324AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB.
  • 基因功能參考文獻:
    1. research achievements of SENP2 are reviewed in order to understand its related functions and the underlying molecular mechanisms and provide a clue for future research on SENP2 PMID: 29908207
    2. Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. PMID: 29146736
    3. Data demonstrate that downregulation of SENP2 is correlated with poor prognosis in bladder cancer; SENP2 inhibits TGF-beta signaling and TGF-beta-induced EMT of bladder cancer cell; and that its overexpression contributes to suppress bladder cancer cell invasion and metastasis through deSUMOylation of TGF-betaRI. PMID: 28574613
    4. The variability of the SENP1 and SENP2 genes may play a role in breast cancer occurrence. PMID: 27178176
    5. SENP2 inhibits MMP13 expression in BC cells through de-SUMOylation of TBL1/TBLR1, which inhibits nuclear translocation of beta-catenin. PMID: 26369384
    6. miR-181b targets SENP2 and positively regulated NF-kappaB activity. NF-kappaB activation by DNA damage in GBM cells confers resistance to radiation-induced death. PMID: 25633526
    7. data identify SENP2 as an important regulator of fatty acid metabolism in skeletal muscle PMID: 25784542
    8. SENP2 regulates the transcriptional function of MEF2A via direct de-SUMOylation. PMID: 25483061
    9. p90RSK-mediated SENP2-T368 phosphorylation is a master switch in disturbed-flow-induced signaling. PMID: 25689261
    10. ESR1 repression by SENP2 is independent of its SUMO protease activity. PMID: 24422630
    11. Many nucleoporins are mislocalized and, in some cases, reduced in level when SENP1 and SENP2 are codepleted. PMID: 24196834
    12. Chromosome segregation depends on precise spatial and temporal control of sumoylation in mitosis; SENP1 and SENP2 are important mediators of this control. PMID: 24048451
    13. The SENP1 levels are influenced by the presence of Nup153, whereas SENP2 is not sensitive to changes in Nup153 abundance. PMID: 22688647
    14. SENP2 inhibited bladder cancer cells migration and invasion by regulating the expression of MMP13. PMID: 24008762
    15. SENP2 plays an important role in determining the dynamics and functional outcome of MEF2A SUMOylation and transcriptional activation. PMID: 23224591
    16. SENP2 represses glycolysis and shifts glucose metabolic strategy PMID: 23691130
    17. SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of beta-catenin. PMID: 23098437
    18. cardiac overexpression of SENP2 in the mice with Nkx2.5 haploinsufficiency promoted embryonic lethality and severity of congenital heart diseases (CHDs). PMID: 22155005
    19. Data suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity. PMID: 22028379
    20. SENP2 null cells display biphasic NEMO SUMOylation and activation of IKK and NF-kappaB PMID: 21777808
    21. a mechanism underlying the SENP2-mediated regulation of Mdm2 that is critical for genome integrity in p53-dependent stress responses. PMID: 21183956
    22. Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity. PMID: 20337593
    23. association with the pore plays an important negative role in the regulation of SENP2 PMID: 11896061
    24. Restricting SENP2 in the nucleus by mutations in the NES impairs its polyubiquitination, whereas a cytoplasm-localized SENP2 made by introducing mutations in the NLS can be efficiently polyubiquitinated. PMID: 16738331
    25. Mutational analysis and biochemistry provide a mechanism for SENP2 substrate preferences that explains why SENP2 catalyzes SUMO deconjugation more efficiently than processing PMID: 17099700

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm.
  • 蛋白家族:
    Peptidase C48 family
  • 數據庫鏈接:

    HGNC: 23116

    OMIM: 608261

    KEGG: hsa:59343

    STRING: 9606.ENSP00000296257

    UniGene: Hs.401388



主站蜘蛛池模板: 国产爆乳成av人在线播放| 丰满护士巨好爽好大乳| 亚洲精品久久片久久久久| 亚洲线精品一区二区三八戒| 人人妻人人澡人人爽精品欧美 | 四虎永久在线精品884aa| 超清中文乱码一区| 亚洲人成网站18禁止无码| 久久日本三级韩国三级| 欲香欲色天天综合久久| 好男人在线社区www在线影院| 无码丰满熟妇| 久久精品国产99国产精2020丨 | 成熟老妇女毛茸茸的做性| 在线成人一区二区| 午夜无码乱码在线观看| 亚洲大尺度无码无码专线| 色屁屁www影院免费观看| 乌克兰少妇videos高潮| 女人被做到高潮免费视频| 人人妻碰人人免费| 无码av免费网站| 久久久婷婷五月亚洲97号色| 久久伊99综合婷婷久久伊| 在线看片国产日韩欧美亚洲| 亚洲人成在线影院| 少妇被粗大的猛烈进出图片| 国产又粗又黄又爽的大片| 久久无码专区国产精品| 免费无码不卡视频在线观看| 国产在线无码一区二区三区| 亚洲国产成人无码精品| 日本丰满熟妇videos| 久久精品人妻无码一区二区三区v 国产薄丝脚交视频在线观看 | 亚洲精品乱码久久久久久按摩| 国产精品兄妹在线观看麻豆| 啊轻点内射在线视频| 久久精品日韩av无码| 色噜噜狠狠色综合久夜色撩人| 中文字幕久久久久人妻中出| 国产成人精品自在线拍|