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  4. SEMA6A Antibody

SEMA6A Antibody

  • 中文名稱：
    SEMA6A兔多克隆抗體
  • 貨號：
    CSB-PA247632
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA247632(SEMA6A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SEMA6A
  • 別名：
    HT018 antibody; SEM6A_HUMAN antibody; SEMA antibody; Sema domain; transmembrane domain (TM); and cytoplasmic domain; (semaphorin) 6A antibody; Sema Q antibody; Sema VIA antibody; SEMA6A 1 antibody; Sema6a antibody; SEMA6A-1 antibody; SEMA6A1 antibody; Semaphorin 6A 1 antibody; Semaphorin Q antibody; Semaphorin VIA antibody; Semaphorin-6A antibody; Semaphorin-6A-1 antibody; SEMAQ antibody; VIA antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human SEMA6A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.; (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
  • 基因功能參考文獻：
    1. describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function PMID: 27787863
    2. miR-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A. PMID: 28982852
    3. our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of Glioblastoma multiforme PMID: 26014517
    4. Data suggest that Sema6A and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma. PMID: 25576923
    5. We identified the SEMA6A and HLA-DP loci as significant contributors to risk for granulomatosis with polyangiitis. PMID: 23740775
    6. Data show that miR-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3'-untranslated region of SEMA6A. PMID: 22184411
    7. Strong expression of SEMA6A is associated with langerhans cells of histiocytosis or dermatopathic lymphadenitis PMID: 16436660
    8. NANOG-, SOX2-, and POU5F1 (OCT3/OCT4)-binding sites within intron 1 of the SEMA6A gene PMID: 17671748
    9. findings suggest for SEMA6A a novel function in the cytoskeleton and a role in modulating tubulin isotype composition and microtubule dynamics PMID: 18187809

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Semaphorin family
  • 數據庫鏈接：

    HGNC: 10738

    OMIM: 605885

    KEGG: hsa:57556

    STRING: 9606.ENSP00000345512

    UniGene: Hs.156967



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