在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEC14L2 Antibody, FITC conjugated

  • 中文名稱:
    SEC14L2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA020937LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SEC14L2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SEC14L2
  • 別名:
    Alpha tocopherol associated protein antibody; Alpha-tocopherol-associated protein antibody; C22orf6 antibody; hTAP antibody; KIAA1186 antibody; KIAA1658 antibody; MGC65053 antibody; OTTHUMP00000198972 antibody; OTTHUMP00000198973 antibody; OTTHUMP00000198974 antibody; OTTHUMP00000199021 antibody; S14L2_HUMAN antibody; SEC14 (S. cerevisiae) like 2 antibody; SEC14 like 2 (S. cerevisiae) antibody; SEC14 like protein 2 antibody; SEC14-like protein 2 antibody; Sec14l2 antibody; SPF antibody; Squalene transfer protein antibody; Supernatant protein factor antibody; TAP antibody; TAP1 antibody; tocopherol-associated protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human SEC14-like protein 2 protein (233-358AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
  • 基因功能參考文獻:
    1. Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC). PMID: 28463110
    2. hTAP1 reduces the in vitro activity of the phosphatidylinositol-3-kinase gamma (PI3Kgamma) indicating the formation of a stalled/inactive hTAP1/PI3Kgamma heterodimer. PMID: 24983950
    3. PI3Kgamma-induced VEGF expression was reduced when the human tocopherol-associated protein 1 (hTAP1/SEC14L2) was overexpressed suggesting formation of an inactive PI3Kgamma/hTAP1 heterodimer. PMID: 25290554
    4. SEC14L2 enabled RNA replication of diverse HCV genotypes in several human hepatoma cell lines PMID: 26266980
    5. novel association between the rs737723 polymorphism (SEC14L2/TAP) and higher primary open-angle glaucoma risk PMID: 23401652
    6. TAP expression was significantly correlated with Her2/neu receptor expression and breast cancer stage. PMID: 23411208
    7. Discusses cloning of rat SEC14-like protein 3 and mentions three human SPF-related genes, known as SEC14-like protein 1, 2 and 3. PMID: 15033454
    8. SPF has two domain topology, and the ligand binding cavity has a peculiar horseshoe-like shape PMID: 12429094
    9. phosphorylation enhances its ability to stimulate microsomal squalene monooxygenase; phosphorylation may provide a means for the rapid short term modulation of cholesterol synthesis PMID: 12454003
    10. Data report the three-dimensional crystal structure of human supernatant protein factor in complex with RRR-alpha-tocopherylquinone, the major physiological oxidation product of RRR-alpha-tocopherol, at a resolution of 1.95A. PMID: 12972248
    11. TAP not only mediates vitamin E absorption to facilitate vitamin E antiproliferation effect in prostate cancer cells, but also functions like a tumor suppressor gene to control cancer cell viability through a non-vitamin E manner. PMID: 16267002
    12. reduced expression of TAP was associated with the cell proliferation status of prostate cancer, adverse pathological parameters and the increased risk of recurrence PMID: 17334589
    13. Genetic variation in TTPA and SEC14L2 is associated with serum alpha-tocopherol but does not have a direct effect on prostate cancer when vitamin E is administered. PMID: 19190344
    14. These findings are consistent with alpha-tocopherol-associated protein acting as an antiproliferative factor in estrogen-receptor-positive luminal cells in normal/benign breast tissue PMID: 19305383
    15. Fndings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis. PMID: 19909011

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
  • 組織特異性:
    Widely expressed. Strong expression in liver, brain and prostate.
  • 數據庫鏈接:

    HGNC: 10699

    OMIM: 607558

    KEGG: hsa:23541

    STRING: 9606.ENSP00000316203

    UniGene: Hs.335614



主站蜘蛛池模板: 国产在热线精品视频99公交| 国产午夜亚洲精品国产成人| 国产午夜福利内射青草| 综合激情五月综合激情五月激情1| 已婚少妇美妙人妻系列| 国产丶欧美丶日本不卡视频| 日韩一区二区三区精品| 人妻精品制服丝袜久久久| 欧美另类又黄又爽的a片| 男女啪啪网站大全免费| 日韩激情无码不卡码| 免费无码va一区二区三区| 在线观看麻豆国产成人av在线播放| 美女mm131午夜福利在线| 亚洲欧洲日产国码无码| 天天躁夜夜躁av天天爽| 久久久久噜噜噜亚洲熟女综合| 欧美日韩精品无码一本二本三本色| 国产成人毛片无码视频软件| 日本污ww视频网站| 午夜dv内射一区区| 国产精品久久久国产盗摄| 日本一道一区二区视频| 国产成人18黄网站| 亚洲欧美在线观看| 美女露出奶头扒开尿口免费网站| 久久精品免费国产大片| 男女做爰猛烈啪啪吃奶伸舌头下载| 真人与拘做受免费视频一| 豆国产97在线 | 亚洲| 丝袜自慰一区二区三区| 日本丰满老妇bbw| 999久久久国产精品| 亚洲精品成人无码中文毛片不卡| 无码av中文字幕免费放| 美女又大又黄www免费网站| 亚洲国产成人久久综合区| 国产成人精品日本亚洲77上位| 精品国产你懂的在线观看| 在线天堂最新版资源| 亚洲精品色在线网站|