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SDF4 Antibody, FITC conjugated

  • 中文名稱:
    SDF4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA861120LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SDF4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SDF4
  • 別名:
    45 kDa calcium-binding protein antibody; Cab45 antibody; CAB45_HUMAN antibody; Calcium binding protein antibody; PSEC0034 antibody; SDF 4 antibody; SDF-4 antibody; SDF4 antibody; Stromal cell derived factor 4 antibody; Stromal cell-derived factor 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 45 kDa calcium-binding protein (37-362AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.; Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
  • 基因功能參考文獻:
    1. Ca(2+)-dependent changes in Cab45 mediate sorting of specific cargo molecules at the trans-Golgi network. PMID: 27138253
    2. Data reveal that the ability of Cab45S to inhibit SERCA2b activity is crucial for its role as a modulator of cell proliferation and tumor growth. PMID: 25772237
    3. The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia. PMID: 25509878
    4. Cab45S, a novel regulator of GRP78/BiP, suppresses endoplasmic reticulum stress-induced IRE1 activation and apoptosis by binding to and elevating GRP78/BiP, and has a role in the inhibition of ER stress-induced apoptosis. PMID: 24810055
    5. Calcium is required for the retention of Cab45 in the Golgi membranes, where Cab45 binds secretory cargo in a calcium-dependent reaction. PMID: 23266954
    6. In a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 was identified as an interaction partner of Munc18b. PMID: 17442889
    7. SDF-2, SDF-4 and SDF-5 are expressed in mammary tissues and cells and that a reduced level of SDF-2 and SDF-4 are associated with a poor clinical outcome. PMID: 19513569

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  • 亞細胞定位:
    [Isoform 1]: Golgi apparatus lumen.; [Isoform 5]: Cytoplasm. Cell membrane. Cell projection, bleb.
  • 蛋白家族:
    CREC family
  • 組織特異性:
    Ubiquitous. Isoform 5 is expressed in pancreas.
  • 數據庫鏈接:

    HGNC: 24188

    OMIM: 614282

    KEGG: hsa:51150

    STRING: 9606.ENSP00000353094

    UniGene: Hs.42806



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