在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SCP2 Antibody

  • 中文名稱:
    SCP2兔多克隆抗體
  • 貨號:
    CSB-PA020856DA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: SCP2 antibody at 2µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 59, 16, 35, 51, 7, 55, 57 kDa
      Observed band size: 59 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA020856DA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SCP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DKFZp686C12188 antibody; DKFZp686D11188 antibody; NLTP antibody; NLTP_HUMAN antibody; Non-specific lipid-transfer protein antibody; Nonspecific lipid transfer protein antibody; NSL TP antibody; NSL-TP antibody; OTTHUMP00000010488 antibody; OTTHUMP00000231766 antibody; OTTHUMP00000231767 antibody; OTTHUMP00000231768 antibody; OTTHUMP00000231769 antibody; OTTHUMP00000231770 antibody; OTTHUMP00000231772 antibody; OTTHUMP00000231773 antibody; OTTHUMP00000231774 antibody; OTTHUMP00000231776 antibody; OTTHUMP00000234662 antibody; Propanoyl CoA C acyltransferase antibody; Propanoyl-CoA C-acyltransferase antibody; SCP 2 antibody; SCP chi antibody; SCP X antibody; SCP-2 antibody; SCP-chi antibody; SCP-X antibody; SCP2 antibody; SCPchi antibody; SCPX antibody; Sterol carrier protein 2 antibody; Sterol carrier protein X antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Non-specific lipid-transfer protein (1-143AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,SCP2 Antibody (CSB-PA020856DA01HU),的標記方式是Non-conjugated。對于SCP2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA020856DB01HU SCP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA020856DC01HU SCP2 Antibody, FITC conjugated
    Biotin CSB-PA020856DD01HU SCP2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.; Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
  • 基因功能參考文獻:
    1. We (1) analyzed the structural basis of the fold and the classification of SCP2 domains; (2) identified structure-determined sequence features; (3) compared the lipid binding cavity of SCP2 and other lipid binding proteins; (4) surveyed proposed mechanisms of SCP2 mediated lipid transfer between membranes; and (5) uncovered a possible new function of the SCP2 domain as a protein-protein recognition device. PMID: 28284963
    2. imported protein sterol carrier protein 2 (SCP2) occupies only a subregion of larger peroxisomes, highlighting the heterogeneous distribution of proteins even within the peroxisome. PMID: 27311714
    3. Mice harboring a deletion of the Scp2 locus present a modulated diurnal accumulation of lipids in the liver and a perturbed activation of several signaling pathways including PPARalpha, SREBP, LRH-1, TORC1 and its upstream regulators. PMID: 27097688
    4. We conclude that SCP-2 is a low affinity binding protein for arachidonylethanolamine that can facilitate its cellular uptake but does not contribute significantly to intracellular sequestration of AEA. PMID: 24510313
    5. cellular SCP-2 not only binds and translocates cholesterol but also cholesterol hydroperoxides, thus expanding their redox toxicity and signaling ranges under oxidative stress conditions PMID: 20656919
    6. Statistical analysis indicated that six genes, NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. PMID: 20677014
    7. data for the first time showed that while the N-terminal membrane binding domain of SCP(2) was itself inactive in mediating intermembrane sterol transfer, it nevertheless potentiated the ability of SCP(2) to enhance sterol transfer PMID: 12356316
    8. plays a hitherto unrecognized role in intracellular phosphatidylinositol transfer, distribution, and signaling PMID: 12641450
    9. SCP2 in the cellular defense against oxidative damage and found that a fluorescent fatty acid analog bound to SCP2 is protected against H2O2/Cu2+-induced oxidative damage PMID: 14563822
    10. Overexpression of human SCP-2 in murine fibroblasts significantly alters the sterol dynamics of caveolae/lipid rafts, but not nonlipid raft domains, to facilitate retention of cholesterol within the cell. PMID: 14661971
    11. By trafficking cholesterol hydroperoxides and phospholipid hydroperoxides in addition to parent lipids, SCP2 may exacerbate cell injury under oxidative stress conditions PMID: 15449949
    12. Long chain fatty acyl-coenzyme A (CoA)s are confirmed to be high affinity ligands for SCP2, while long chain fatty acyl-carnitines are demonstrated for the first time not to interact with SCP2. PMID: 17418802
    13. the importance of the N-terminal presequence in regulating SCP-2 structure, cholesterol localization within the ligand binding site, membrane association, and, potentially, intracellular targeting PMID: 18465878
    14. Results describe the dynamical effect of sterol carrier protein-2 (SCP-2) interacting between aqueous dispersions of dehydroergosterol monohydrate microcrystal donors and acceptors. PMID: 19020914

    顯示更多

    收起更多

  • 相關疾病:
    Leukoencephalopathy with dystonia and motor neuropathy (LKDMN)
  • 亞細胞定位:
    [Isoform SCP2]: Peroxisome. Cytoplasm. Mitochondrion. Endoplasmic reticulum. Mitochondrion.; [Isoform SCPx]: Peroxisome.
  • 蛋白家族:
    Thiolase family
  • 組織特異性:
    Liver, fibroblasts, and placenta.
  • 數據庫鏈接:

    HGNC: 10606

    OMIM: 184755

    KEGG: hsa:6342

    STRING: 9606.ENSP00000360569

    UniGene: Hs.476365



主站蜘蛛池模板: 人人妻人人澡人人爽人人精品97| 欧美亚洲日韩国产人成在线播放| 免费看美女被靠到爽的视频| 亚洲综合日韩久久成人av| 日韩欧美精品有码在线| 国产美女裸体无遮挡免费视频| 射死你天天日| 在线不卡日本v二区到六区| 中文字幕v亚洲日本在线电影| 国产成人精品无码免费看| 97在线视频人妻无码 | 午夜福利精品亚洲不卡| 曰韩a∨无码一区二区三区| 无码爆乳护士让我爽| 乱码av麻豆丝袜熟女系列| 中文字幕无码专区一va亚洲v专区在线 | 欧美日韩欧美| 99久久国产自偷自偷免费一区| 国产福利酱国产一区二区| 五月婷婷久久草丁香| 日本妇人成熟免费| 国产成人8x人在线视频软件| 亚洲中文在线精品国产| 天天做天天摸天天爽天天爱| 国产未发育呦交视频| 亚洲成αv人片在线观看| 大陆极品少妇内射aaaaa| 无码h片在线观看网站| 亚洲国产精品一区二区动图 | 久久和欧洲码一码二码三码| 久久www免费人成_看片中文| 国产一三四2021不卡| 无码熟熟妇丰满人妻啪啪| 亚洲中文精品久久久久久| 欧美拍拍视频免费大全| 丰满诱人的人妻3| 大陆国产乱人伦| 又大又硬又黄的免费视频| 日韩精品人妻中文字幕有码| 国产女人高潮抽搐叫床视频| 日韩人妻中文无码一区二区三区|