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  4. SCN4B Antibody

SCN4B Antibody

  • 中文名稱：
    SCN4B兔多克隆抗體
  • 貨號：
    CSB-PA004055
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using Scn4b Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SCN4B
  • 別名：
    SCN4B antibody; Sodium channel subunit beta-4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Scn4b.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
  • 基因功能參考文獻：
    1. SCN4B overexpression reduces cancer cell invasiveness and tumour progression. PMID: 27917859
    2. Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID: 29723302
    3. Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion. PMID: 28655765
    4. The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption PMID: 25450227
    5. results suggest the presence of a docking site that is maintained by a cysteine bridge buried within the hydrophobic core of beta4. PMID: 24297919
    6. this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene. PMID: 23604097
    7. SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells. PMID: 22842345
    8. The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis. PMID: 20226894
    9. The paroxysmal extreme pain disorder associated Nav1.7 missense mutations M1627K, T1464I and V1299F increase Navbeta4 peptide-mediated resurgent sodium currents, in contrast to the erythromelalgia associated I848T and L858H Nav1.7 missense mutations. PMID: 21115638
    10. molecular cloning and characterization of sodium channel beta4 PMID: 12930796
    11. SCN4B is a long QT syndrome susceptibility gene. PMID: 17592081
    12. Co-expression of the beta1 subunit impeded slow inactivation elicited by a 30-s depolarization, such that the voltage dependence was right shifted (depolarized) and recovery was hastened. PMID: 18941776

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  • 相關疾病：
    Long QT syndrome 10 (LQT10); Atrial fibrillation, familial, 17 (ATFB17)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
  • 組織特異性：
    Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
  • 數據庫鏈接：

    HGNC: 10592

    OMIM: 608256

    KEGG: hsa:6330

    STRING: 9606.ENSP00000322460

    UniGene: Hs.65239



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