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  4. SCN3A Antibody

SCN3A Antibody

  • 中文名稱：
    SCN3A兔多克隆抗體
  • 貨號：
    CSB-PA885761ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA885761ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA885761ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SCN3A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SCN3A
  • 別名：
    brain III voltage-gated sodium channel antibody; NAC3 antibody; Nav1.3 antibody; SCN3A antibody; SCN3A_HUMAN antibody; Sodium channel protein brain III subunit alpha antibody; Sodium channel protein type 3 subunit alpha antibody; Sodium channel protein type III subunit alpha antibody; Sodium channel protein, brain III subunit alpha antibody; sodium channel, brain type III, alpha subunit antibody; sodium channel, neuronal type III, alpha subunit antibody; sodium channel, voltage-gated, type III, alpha polypeptide antibody; sodium channel, voltage-gated, type III, alpha subunit antibody; Voltage gated sodium channel subtype III antibody; Voltage gated sodium channel subunit alpha Nav1.3 antibody; Voltage-gated sodium channel subtype III antibody; Voltage-gated sodium channel subunit alpha Nav1.3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sodium channel protein type 3 subunit alpha protein (274-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells. In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion.
  • 基因功能參考文獻：
    1. SCN3A is involved in development of the human brain and oral motor development. When SCN3A is mutated, patients present with polymicrogyria and speech deficits. PMID: 30146301
    2. Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp mice display increased seizure susceptibility, hypoactivity, and impaired motor learning. PMID: 28235671
    3. sodium channel currents in oocytes expressing either wild-type or mutant (A4V) SOD1 protein PMID: 27072680
    4. Discovery of a common biophysical defect among variants identified in unrelated pediatric epilepsy patients suggests that SCN3A may contribute to neuronal hyperexcitability and epilepsy. PMID: 24157691
    5. Upregulation of Nav1.3 protein and a specific cellular distribution of Nav1.3 proteins in focal cortical dysplasia type IIb(FCDIIb) lesion tissue samples suggest that Nav1.3 may be involved in the generation of epileptic activity in FCDIIb. PMID: 22494998
    6. Deletions in SCN3A gene is associated with autistic features and developmental delay. PMID: 20346423
    7. In trigeminal neuralgia (TN) there is a reduction in the expression of Nav1.7 and an increase in the expression of Nav1.3, Nav1.8 expression not significantly different; TN can be, at least in part, a channelopathy. PMID: 19699781
    8. in autism families, two polymorphic coding variants of SCN3A are described PMID: 12610651
    9. Characterization of 5' untranslated regions SCN3A, and identification of cis-conserved noncoding sequences. PMID: 17544618

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, Nav1.3/SCN3A subfamily
  • 組織特異性：
    Expressed in enterochromaffin cells in both colon and small bowel (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10590

    OMIM: 182391

    KEGG: hsa:6328

    STRING: 9606.ENSP00000283254

    UniGene: Hs.435274



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