在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SCG5 Antibody

  • 中文名稱:
    SCG5兔多克隆抗體
  • 貨號:
    CSB-PA020810GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SCG5
  • 別名:
    SCG5 antibody; SGNE1Neuroendocrine protein 7B2 antibody; Pituitary polypeptide antibody; Secretogranin V antibody; Secretogranin-5 antibody; Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SCG5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
  • 基因功能參考文獻:
    1. Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5-GREM1 duplication. PMID: 27984123
    2. FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
    3. 7B2 chaperones blocked the cytotoxic effects of exogenous hIAPP PMID: 24042052
    4. conclude that 7B2 is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers PMID: 22947085
    5. data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease PMID: 23172224
    6. the significant effects of SGNE1/7B2 on the growth and apoptosis of glioblastoma cells provide a first proof for a functional implication of SGNE1/7B2 inactivation in the molecular pathology of gliomas. PMID: 21901745
    7. SGNE1 was overexpressed in gastrointestinal peptide-independent ACTH-independent macronodular adrenal hyperplasia. hyperplasia PMID: 14767469
    8. SGNE1 identified as a novel epigenetically silenced gene in medulloblastomas and its inactivation, as well as its inhibitory effect on tumor cell proliferation and focus formation strongly argues for a significant role in medulloblastoma development. PMID: 17334394
    9. SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity PMID: 17617923
    10. Secretogranins V assays failed to detect increased concentrations in any of the patients with neuroendocrine tumours. PMID: 18448176

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族:
    7B2 family
  • 數據庫鏈接:

    HGNC: 10816

    OMIM: 173120

    KEGG: hsa:6447

    STRING: 9606.ENSP00000300175

    UniGene: Hs.156540



主站蜘蛛池模板: 午夜精品一区二区三区免费视频| 国产精品天堂avav在线| 国产 国语对白 露脸| 精品久久国产字幕高潮| 自拍性旺盛老熟女| 女的被弄到高潮娇喘喷水视频| 香蕉伊蕉伊中文视频在线| 国内精品久久久久影院免费| 日产a一a区二区www| 久久婷婷五月综合97色| 日韩欧美成人免费观看| 亚洲人成无码区在线观看| 国内精品久久久久影院中文字幕| 天天爽夜夜爽视频精品| 欧美内射深喉中文字幕| 久久99精品国产.久久久久| 欧美日韩亚洲tv不卡久久| 伊人久久久大香线蕉综合直播| 成人精品视频99在线观看免费| 日本三级理论久久人妻电影| 九九线精品视频在线观看| 亚洲va在线∨a天堂va欧美va| 欧美疯狂性受xxxxx另类| 人妻丝袜av中文系列先锋影音 | 无码中文字幕波多野结衣 | 在线 亚洲 国产 欧美| 国产综合一区二区三区黄页秋霞| 久久久久久成人毛片免费看| 中文无码熟妇人妻av在线| 国语对白做受xxxxx在| 99久久人妻精品免费一区| 亚洲综合无码一区二区三区| 久久亚洲中文字幕伊人久久大| 俄罗斯少妇性xxxx另类| 国产欧美亚洲精品a| 国产高清av首播原创麻豆| 色综合 图片区 小说区| 久久天天躁狠狠躁夜夜爽| 欧美激情精品久久| 亚洲伊人丝袜精品久久| 麻豆成人久久精品综合网址 |