在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SAV1 Antibody

SAV1 Antibody

  • 中文名稱：
    SAV1兔多克隆抗體
  • 貨號：
    CSB-PA875672ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate, MCF-7 whole cell lysate
      All lanes: SAV1 antibody at 3.64µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA875672ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA875672ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA875672ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • IHC image of CSB-PA875672ESR1HU diluted at 1:364 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SAV1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    1700040G09Rik antibody; 45 kDa WW domain protein antibody; hWW 45 antibody; hWW45 antibody; Protein salvador homolog 1 antibody; salvador family WW domain containing protein 1 antibody; salvador homolog 1 (Drosophila) antibody; Salvador homolog 1 antibody; Salvador, Drosophila, homolog of antibody; SAV 1 antibody; SAV antibody; SAV1 antibody; SAV1_HUMAN antibody; WW 45 antibody; WW domain containing antibody; WW domain-containing adaptor 45 antibody; WW domain-containing protein, 45-KD antibody; WW45 antibody; WW45 protein antibody; WWP 4 antibody; WWP4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein salvador homolog 1 protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
  • 基因功能參考文獻：
    1. These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway. PMID: 29519817
    2. Here, the authors discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2 activation. PMID: 29063833
    3. WW45 has suppressive roles in lung cancer through a pathway involving Hedgehog/Gli1 signaling. PMID: 27661123
    4. SAV1 represses the activation of the Akt-mTOR signalling, and rapamycin treatment blunts the effects of SAV1 on in vitro and in vivo growth of colorectal cancer cells. PMID: 28618450
    5. using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 refolded under acidic pH. PMID: 25814670
    6. MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes. PMID: 25367221
    7. Mst2 and the Ser-3 residue of human WW45 function independently of each other in the regulation of the stability of human WW45. PMID: 23524264
    8. We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells. PMID: 22570112
    9. downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade clear cell renal cell carcinoma. PMID: 22185343
    10. MST and hSAV act as novel co-regulators of ERalpha and may play an important role in breast cancer pathogenesis. PMID: 21104395
    11. hSav1 interacts with HAX1 and attenuates its protective role against apoptosis in MCF-7 breast cancer cells. PMID: 21567072
    12. a role for Salvador as a human tumor suppressor and RASSF1A effector and show that Salvador allows RASSF1A to modulate p73 independently of the hippo pathway. PMID: 21489991
    13. Study reports that two Hippo pathway components, Mst2 and the scaffold protein hSav1, directly interact with Nek2A and regulate its ability to localize to centrosomes, and phosphorylate C-Nap1 and rootletin. PMID: 21076410
    14. hSav1 is a newly identified protein that interacts with Mst1 and augments Mst1-mediated apoptosis. PMID: 19950692
    15. Salvador gene is not frequently mutated in human carcinoma tissues. PMID: 12969014
    16. Together these results show that hSav can bind to, and be phosphorylated by, Mst, and that the stabilizing effect of Mst on hSav requires its interaction with hSav but is probably not due to phosphorylation of hSav by Mst. PMID: 16930133
    17. hWW45 is required to enhance MST1-mediated apoptosis in vivo and thus is a critical player in an MST1-driven cell death signaling pathway. PMID: 19212654

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
  • 數據庫鏈接：

    HGNC: 17795

    OMIM: 607203

    KEGG: hsa:60485

    STRING: 9606.ENSP00000324729

    UniGene: Hs.642842



主站蜘蛛池模板： 色欧美片视频在线观看| 亚洲偷精品国产五月丁香麻豆 | 性色a∨人人爽网站hdkp885| 2020久久超碰国产精品最新| 国产全是老熟女太爽了| 狠狠躁夜夜躁人人爽超碰97香蕉 | 成人爱做日本视频免费 | 不卡无码av一区二区三区| 国产麻豆精品精东影业av网站| 人妻无码精品久久亚瑟影视 | 99久久精品国产一区二区三区| 日韩a毛片免费观看| 国产成人精品日本亚洲语音| 久久精品国产精品亚洲艾草网| 少妇又紧又色又爽又刺激视频| 中文字幕aav| 无码专区—va亚洲v专区| 人妻少妇精品视频二区| 欧美高清精品一区二区| av片亚洲国产男人的天堂| 377p欧洲日本亚洲大胆| 女人18片毛片60分钟| 国产精品 自在自线| 日本一本一区二区免费播放| 欧美午夜一区二区福利视频| 亚洲精品国精品久久99热| av无码久久久精品免费| 性欧美老妇另类xxxx| 99久久人妻无码精品系列| 日韩国产精品无码一区二区三区| 精品国产卡一卡2卡3卡| 中文字幕亚洲无线码在线一区 | 日本电影一区二区三区| 丁香五月缴情在线| 亚洲精品久久久久午夜福利| 看免费真人视频网站| 又色又爽又高潮免费观看| 最新亚洲一卡二卡三卡四卡| 三个男吃我奶头一边一个视频| 99久久久无码国产精品古装| 日韩精品无码人成视频|