在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SAR1A Antibody

  • 中文名稱:
    SAR1A兔多克隆抗體
  • 貨號:
    CSB-PA020702GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    COPII associated small GTPase antibody; COPII-associated small GTPase antibody; GTP binding protein SAR1a antibody; GTP-binding protein SAR1a antibody; Masra 2 antibody; Masra2 antibody; SAR 1 antibody; SAR1 gene homolog A antibody; SAR1 homolog A (S. cerevisiae) antibody; SAR1A antibody; SAR1a gene homolog (S cerevisiae) 1 antibody; SAR1a gene homolog 1 (S cerevisiae) antibody; SAR1a gene homolog 1 antibody; SAR1A_HUMAN antibody; SARA 1 antibody; Sara antibody; SARA1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SAR1A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
  • 基因功能參考文獻:
    1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
    2. Study shows that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which blocks COPII vesicle fission from the endoplasmic reticulum. PMID: 29718541
    3. No associations were observed between any of the secretion associated Ras related GTPase 1A (SAR1a) promoter variants and baseline fetal hemoglobin HbF among sickle cell disease (SCD) patients. PMID: 28499394
    4. Sar1 is a novel regulator of endoplasmic reticulum-mitochondrial contact sites in the metazoans. PMID: 27101143
    5. SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin, arresting PDIA3 in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture. PMID: 26607390
    6. Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin expression, predominantly through the Gialpha/JNK/Jun pathway. PMID: 24914133
    7. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
    8. Sar1 mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization. PMID: 22605651
    9. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
    10. Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils. PMID: 23019651
    11. lipid-directed and tether-assisted Sar1 organization controls membrane constriction to regulate ER export. PMID: 20624903
    12. the intracellular trafficking of hCaR from the endoplasmic reticulum is Sar1-dependent via coat protein complex-II vesicles. PMID: 20457124
    13. The Sec31 fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 and Sec23 residues at the Sar1 GTPase active site explains how GTP hydrolysis is triggered leading to COPII coat disassembly. PMID: 17981133
    14. Sar 1 H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. PMID: 19135528
    15. Kir6.2 contains a di-acidic endoplasmic reticulum exit signal, which promotes endoplasmic reticulum exit via a process that requires Sar1. PMID: 19357197

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族:
    Small GTPase superfamily, SAR1 family
  • 數據庫鏈接:

    HGNC: 10534

    OMIM: 607691

    KEGG: hsa:56681

    STRING: 9606.ENSP00000362335

    UniGene: Hs.499960



主站蜘蛛池模板: 最新精品香蕉在线| 亚洲婷婷五月激情综合app| 国产做a爰片久久毛片a片美国| 欧美人和黑人牲交网站上线| 中国猛少妇色xxxxx| 成人欧美一区二区三区| 日韩亚洲欧美中文在线| 大学生被内谢粉嫩无套| 日本亚洲欧美日韩国产ay| 一区二区三区四区在线 | 欧洲| 国产美女久久久亚洲综合| 无卡无码无免费毛片| 精品无码无人网站免费视频| 免费观看又色又爽又黄的韩国| 无码专区天天躁天天躁在线| 秋霞电影网午夜鲁丝片无码| 中文字幕奈奈美被公侵犯| 亚洲开心婷婷中文字幕| 久久精品一区二区免费播放| 三级特黄60分钟在线播放| 五月开心播播网| 欧美人牲口杂交在线播放免费| 末发育娇小性色xxxxx| 亚洲成成熟女人专区| 艳妇臀荡乳欲伦交换h在线观看 | 两个人看的www视频免费完整版| 妺妺窝人体色www聚色窝仙踪| 亚洲日本va午夜中文字幕久久| 末成年毛片在线播放| 亚洲hdmi高清线| 无码精品人妻一区二区三区漫画| 精品国产精品久久一区免费式| 亚洲欧洲无码av电影在线观看| 国产v片在线播放免费无遮挡| 国产md视频一区二区三区| 狠狠色综合tv久久久久久| 亚洲精品国产品国语在线观看| 伊人久久精品在热线热| 女狠狠噜天天噜日日噜| 18禁无遮挡啪啪无码网站| 亚洲成a人片77777kkkk|