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Rgn Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    Rgn兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA019630LB01RA
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Rattus norvegicus (Rat) Rgn Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    Rgn
  • 別名:
    Rgn antibody; Smp30 antibody; Regucalcin antibody; RC antibody; Gluconolactonase antibody; GNL antibody; EC 3.1.1.17 antibody; Senescence marker protein 30 antibody; SMP-30 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Rat
  • 免疫原:
    Recombinant Rat Regucalcin protein (1-299AA)
  • 免疫原種屬:
    Rattus norvegicus (Rat)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities.
  • 基因功能參考文獻(xiàn):
    1. The renal SMP30 expression levels positively correlated with plasma testosterone levels in the kidney. PMID: 27553527
    2. Melatonin may produce a neuroprotective effect through its antioxidant action and by increasing hippocampal expression of SMP30 and osteopontin. PMID: 29602294
    3. n. These results showed the effect of RGN in inhibiting the glycolytic metabolism in rat prostate, which was underpinned by a reduced cell proliferation index. The present findings also suggest that the loss of RGN may predispose to a hyper glycolytic profile and fostered proliferation of prostate cells PMID: 26553531
    4. results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa. PMID: 26171977
    5. RGN overexpression protects germ cell from apoptosis induced by noxious stimuli, which could be a relevant mechanism for fertility preservation in situations of oncological treatments. PMID: 24519986
    6. A diminished influx of Ca2+ in epididymal tissues of RGN-overexpressing rats resulted in compromised sperm motility. PMID: 23615721
    7. Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging PMID: 22652898
    8. existence of multiple forms of SMP30 PMID: 21347421
    9. Rgn is a novel androgen-target gene in rat testis and may have a role in male reproductive function, particularly in the control of spermatogenesis. PMID: 21680783
    10. Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function. PMID: 21431902
    11. SMP30 protein levels were not altered in cortex and cerebellum of young (6 months) and old (21 months) rats. PMID: 19437547
    12. effect of regucalcin, a regulatory protein of Ca2+ signaling, on guanosine-5'-triphosphatase (GTPase) activity in isolated rat liver plasma membranes was investigated; GTPase activity was significantly increased by the addition of Ca2+ PMID: 11693188
    13. study demonstrates that endogenous regucalcin has a suppressive effect on DNA synthesis in the nuclei of rat renal cortex PMID: 11936841
    14. endogenous regucalcin plays a suppressive role in the enhancement of nuclear DNA synthesis activity in regenerating liver with cell proliferation after partial hepatectomy in rats. PMID: 11967991
    15. Role of regucalcin as an activator of sarcoplasmic reticulum Ca2+-ATPase activity in rat heart muscle PMID: 12112029
    16. Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity PMID: 12210758
    17. endogenous regucalcin has a suppressive effect on the enhancement of RNA synthesis activity in the nucleus of regenerating rat liver with proliferative cells PMID: 12397604
    18. recombinant RGPR-p117 did not bind directly to the TTGGC sequence of the regucalcin gene promoter region in liver PMID: 12647292
    19. has a suppressive effect on nitric oxide synthase activity in the liver cytosol; may play important role as a regulatory protein of NO synthase in liver cells PMID: 12647304
    20. Endogenous regucalcin has an inhibitory effect on NO synthase activity in the brain cytosol of young and aged rats PMID: 12686401
    21. The present study demonstrates that endogenous regucalcin has a suppressive effect on NO synthase activity in the kidney cortex cytosol of rats PMID: 12851718
    22. endogenous regucalcin plays a suppressive role in the regulation of liver nuclear function in rats PMID: 12851719
    23. endogenous regucalcin plays a suppressive role in the regulation of brain function in rats PMID: 12964038
    24. regucalcin is expressed in rat bone marrow cells, and osteoclastic bone resorption is stimulated in regucalcin transgenic rats with increasing age PMID: 14767576
    25. overexpression of regucalcin has a suppressive effect on cell death induced by TNF-alpha or thapsigargin PMID: 15108356
    26. Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver PMID: 15251439
    27. regucalcin modulates the transcriptional process by binding to protein and DNA in the nucleus PMID: 15254778
    28. Endogenous rgn suppresses protein tyrosine phosphatase activity in rat liver microsomes in transgenic rats. PMID: 15289895
    29. Osteoclastic bone resporption is stimulated in regucalcin transgenic male and female rats with increasing age. PMID: 15289899
    30. The effect of regucalcin in increasing superoxide dismutase (SOD) activity may not involve the sulfhydryl group of SOD. PMID: 15340235
    31. hyperlipidemia is uniquely induced in regucalcin TG rats with increasing age PMID: 15375596
    32. regucalcin increases superoxide dismutase activity in the heart cytosol of rats, and its effect is not related to the sulfhydryl group of enzymes PMID: 15375603
    33. This study demonstrates that regucalcin directly stimulates osteoclast-like cell formation in mouse marrow culture in vitro, and that the protein stimulates bone resorption in rat femoral tissues in vitro PMID: 15578574
    34. Overexpression of regucalcin suppresses sulforaphane-induced apoptotic cell death which is partly mediated through caspase-3. PMID: 15806309
    35. study demonstrates that regucalcin regulates the function of osteoblastic cells, and that the protein suppresses cell differentiation and mineralization PMID: 16052480
    36. Results demonstrate that overexpression of regucalcin has a suppressive effect on cell proliferation, which is mediated through various signaling pathways. PMID: 16142398
    37. This study demonstrates that overexpression of RGPR-p117 enhances the expression of regucalcin mRNA and its protein level in NRK52E cells. RGPR-p117 may play a role as a transcriptional factor. PMID: 16273285
    38. RGPR-p117 can enhance the regucalcin promoter activity which is related to the NF-1 consensus sequences including TTGGC motif, and its enhancing effect is partly mediated through phosphorylation and dephosphorylation PMID: 16676356
    39. the SMP30 transcriptional process is redox-sensitive and its modulation occurs at DNA binding sites 3 and 5 in the promoter region PMID: 16677110
    40. This study demonstrates that overexpression of regucalcin caused a remarkable increase in its nuclear localization, and that it has suppressive effects on the gene expression of L-type Ca(2+) channel or CaR. PMID: 16767692
    41. Results suggest regucalcin has a role in the regulation of heart mitochondrial function. PMID: 16786169
    42. Regucalcin does not have effects as the suppressor for free radical stress and the scavenger for free radical in rats. PMID: 17334641
    43. Leptin mRNA expression in the adipose or liver tissues was significantly decreased in 50-week-old regucalcin transgenic rats. PMID: 17671736
    44. This study demonstrates that overexpression of regucalcin suppresses the enhancing effect of insulin or glucose on the gene expression of insulin signaling-related proteins in the cloned rat hepatoma H4-II-E cells. PMID: 17912465
    45. Data show that regucalcin mRNA and protein are present in rat mammary gland that estradiol down-regulates regucalcin expression. PMID: 18157649
    46. regucalcin has a role in the regulation of Ca(2+)-ATPase activity in the brain mitochondria of rats PMID: 18181158
    47. These studies provide novel insights into the mechanism that regulate SMP30 gene expression. PMID: 18442420

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  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    SMP-30/CGR1 family
  • 組織特異性:
    Detected in liver (at protein level). Hepatocytes and renal proximal tubular epithelium.
  • 數(shù)據(jù)庫鏈接:


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