在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RXFP2 Antibody

  • 中文名稱:
    RXFP2兔多克隆抗體
  • 貨號:
    CSB-PA006978
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using Relaxin Receptor 2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    RXFP2; GPR106; GREAT; LGR8; Relaxin receptor 2; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Relaxin Receptor 2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
  • 基因功能參考文獻:
    1. In the TMD discovery cohort, sex-stratified analysis identified 2 additional genome-wide significant loci in females. One lying upstream of the relaxin/insulin-like family peptide receptor 2 ( RXP2) (chromosome 13, rs60249166,[OR] = 0.65, P = 3.6 x 10(-8)) was replicated among females in the meta-analysis (1-tailed P = 0.052). The other (chromosome 17, rs1531554, OR = 0.68, P = 2.9 x 10(-8)) was replicated among f PMID: 28081371
    2. Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation. PMID: 24983702
    3. Findings suggest a novel and gender-specific role for INSL3 and cognate receptor RXFP2 signaling in ocular surface homeostasis. PMID: 23539510
    4. haplotype analysis of the RXFP2 gene in T222P carriers and their parents showed that this variant is linked to the previously inferred C-C-G-A-13 haplotype and consequently provides further support to the 'founder effect' hypothesis PMID: 20636340
    5. higher expression of LGR8 may facilitate tumor invasiveness in the early clinical stage of hepatocellular carcinoma. PMID: 21789898
    6. Data show that synthetic parallel dimer of the B-chain of INSL3 is a potent inhibitor of the native peptide's binding to its receptor, RXFP2. PMID: 20560146
    7. the only clinical consequence of alterations of the INSL3-LGR8 system seems to be failure of the testis to normally descend in the scrotum during embryonic development, without affecting the spermatogenic and endocrine components of the testis itself PMID: 12970298
    8. mutations involving the human LGR8 gene do not represent a frequent cause of cryptorchidism in the Finnish population PMID: 14656401
    9. recurrent T222P mutation in the LGR8 gene was not found in any of the patients. These data show for the first time a lack of association between genetic factors necessary for correct testicular descent and anorchia. PMID: 15579790
    10. LGR8 signal is activated by the relaxin-like factor PMID: 15708846
    11. LGR8.1 spliced isoform is expressed at the cell surface, unable to stimulate cAMP production. PMID: 16051677
    12. Alanine-substituted analogs were used to identify the key residues of INSL3 that are responsible for the interaction with the ectodomain of LGR8. These include Arg(B16) and Val(B19), with His(B12) and Arg(B20) playing a secondary role. PMID: 16867980
    13. Novel allele of LGR8 (R223K) found in one patient with retractile testes. PMID: 16926383
    14. The V18M mutation in the insulin-like factor 3 signal peptide had a significant deleterious effect in activating LGR8 receptor in ex vivo studies PMID: 17437853
    15. predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229 PMID: 17473281
    16. negative cooperativity is present and that INSL3-RXFP2 binding shows both similarities and differences with insulin binding to the insulin receptor PMID: 18063691
    17. T222P mutation cannot be considered either causative or a susceptibility factor for cryptorchidism. PMID: 18073304
    18. No association between T222P/LGR8 mutation and cryptorchidism in the Moroccan population PMID: 18772597
    19. relaxin binds with high affinity to the leucine-rich repeats of RXFP2 in a manner similar to INSL3 binding to its receptor PMID: 19416162
    20. Several missense mutations were described in both the INSL3 and RXFP2 genes and a novel V39G INSL3 mutation in a patient with cryptorchidism was identified PMID: 19416188
    21. This study confirmed the association between INSL3 and RXFP2 gene mutations and human cryptorchidism. PMID: 19416190
    22. Data link RXFP2 gene mutations with human osteoporosis. PMID: 19416191

    顯示更多

    收起更多

  • 相關疾病:
    Cryptorchidism (CRYPTO)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.
  • 數據庫鏈接:

    HGNC: 17318

    OMIM: 219050

    KEGG: hsa:122042

    STRING: 9606.ENSP00000298386

    UniGene: Hs.680763



主站蜘蛛池模板: 亚洲欧美日韩成人综合一区| 日本无遮挡边做边爱边摸| 7777奇米四色成人眼影| 69sex久久精品国产麻豆| 亚洲欧洲无码一区二区三区| 国产成人精品久久久久精品日日| 天天躁夜夜躁狠狠综合2020| 国产人妻久久精品二区三区老狼 | 忍着娇喘人妻被中出中文字幕| 人妻avav中文系列久久| 日本边添边摸边做边爱边| 131美女爱做视频免费| 精品久久国产字幕高潮| 真人祼交二十三式视频| 天天爽亚洲中文字幕| 亚洲成av人片在线观l看福利1| 国产精品久久一区二区三区| 国产99在线 | 中文| 国产av福利第一精品| 久久久国产乱子伦精品| 艳妇臀荡乳欲伦交换h在线观看| 国产精品igao视频网网址| 亚洲精品无码国产| 中文字幕制服丝袜第57页| 午夜影视免费| 伊人狠狠色丁香婷婷综合| 成人午夜福利院在线观看| 中文字幕一区在线观看视频| 极品少妇xxxx| 蜜桃av无码免费看永久| 免费啪视频在线观看视频日本 | 一二三四在线观看视频韩国| 99久热在线精品视频观看| 国内裸体无遮挡免费视频| 欧美成人天天综合在线| 国产 国语对白 露脸| 激情内射日本一区二区三区| 天堂在/线资源中文在线| 2020年无码国产精品高清免费| 国产内射爽爽大片| 尤物视频在线观看|