在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RSPO3 Antibody, Biotin conjugated

  • 中文名稱:
    RSPO3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA887154LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) RSPO3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RSPO3
  • 別名:
    CRISTIN1 antibody; hPWTSR antibody; hRspo3 antibody; Protein with TSP type-1 repeat antibody; PWTSR antibody; R-spondin 3 homolog antibody; R-spondin-3 [Precursor] antibody; R-spondin-3 antibody; Roof plate specific spondin-3 antibody; Roof plate-specific spondin-3 antibody; RSPO3 antibody; RSPO3_HUMAN antibody; Thrombospondin type I domain containing 2 antibody; Thrombospondin type-1 domain-containing protein 2 antibody; THSD2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human R-spondin-3 protein (22-272AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells. Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.
  • 基因功能參考文獻(xiàn):
    1. Knockdown of RSPO3 resulted in significantly increased mRNA expression levels of RUNX2, ALP and OCN and no effects on the proliferation of human adipose-derived stem cells. PMID: 28220828
    2. For liver transplant-free survival, a genome-wide significant signal was identified and expression of the candidate gene RSPO3 was demonstrated in key liver-resident effector cells and may play a role in primary sclerosing cholangitis disease progression. PMID: 28779025
    3. The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA) and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA. PMID: 28543708
    4. RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway PMID: 27572318
    5. Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. PMID: 28100566
    6. Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt/beta-catenin signaling. PMID: 27350215
    7. High RSPO3 expression is associated with breast cancer. PMID: 26735887
    8. A genome-wide association study of bone mineral density (BMD) found a new BMD locus that harbors the PTCH1 gene, that associates with reduced spine BMD and the RSPO3 associates with increased spine BMD. PMID: 26733130
    9. results suggest that the expression of RSPO fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population PMID: 24847761
    10. using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours PMID: 22895193
    11. the gene is a novel member of thrombospondin type I repeat supergene family (hPWTSR) PMID: 12463421
    12. a polymorphism in thrombospondin subtly but significantly sensitizes the calcium-binding repeats to removal of Ca2+ and thermal denaturation PMID: 12643280

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    R-spondin family
  • 組織特異性:
    Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. Highly expressed in endothelial cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20866

    OMIM: 610574

    KEGG: hsa:84870

    STRING: 9606.ENSP00000349131

    UniGene: Hs.135254



主站蜘蛛池模板: 国产真人作爱免费视频道歉| 久久一本久综合久久爱| 亚洲欧美v国产蜜芽tv| 伊人婷婷六月狠狠狠去| 国产精品久久久久9999爆乳| 成人网站免费观看| 男女啪啪免费观看的网址| 成在人线无码aⅴ免费视频| 337p日本欧洲亚洲大胆裸体艺术| 熟女丰满老熟女熟妇| 国产日产欧产精品精品免费| 18禁美女裸体无遮挡免费观看国产| 亚洲国产av美女网站| 国产成人精品高清在线观看99| 国产巨大爆乳在线观看| 人妻少妇88久久中文字幕| 亚洲另类无码一区二区三区| 国产午夜大地久久| 亚洲熟妇av一区二区三区浪潮| 印度女人狂野牲交| 国产av仑乱内谢| 无码少妇一区二区浪潮免费| 久久www成人免费直播| 久久综合久久综合九色| 亚洲中文字幕无码专区| 亚洲中文字幕av每天更新 | 国产一区二区不卡老阿姨| av天堂永久资源网亚洲高清| 国产精华av午夜在线观看| 亚洲国产成人无码av在线| 伊人色综合九久久天天蜜桃| 日产精品久久久一区二区| 性生交大片免费看女人按摩摩| 全部露出来毛走秀福利视频| 成人无码亚洲精品无码| 色八区人妻在线视频| 久久香蕉综合色一综合色88| 国产精品无码久久四虎| 无码国产精品一区二区免费i6| 乱人伦xxxx国语对白| 97无码免费人妻超级碰碰碰碰 |