在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RPS6KA4 (Ab-568) Antibody

RPS6KA4 (Ab-568) Antibody

  • 中文名稱：
    RPS6KA4 (Ab-568)兔多克隆抗體
  • 貨號：
    CSB-PA903004
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from RAW264.7 cells, treated with UV (5mins), using MSK2 (Ab-568) antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RPS6KA4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C).
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
  • 基因功能參考文獻：
    1. Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT PMID: 28930610
    2. KSHV activates the MSK1/2-CREB1 pathway during primary infection and that it depends on this pathway for viral lytic replication. I PMID: 26109721
    3. Data suggest that MSK1 and MSK2 are the major CREB kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 at Ser-133 plays a significant role in IL-8 production. PMID: 24792438
    4. MSK1 and MSK2 are required for maximal TFF 1 induction. PMID: 23675462
    5. MSK2 functions as an adaptor in mediating PKR activation, apparently independent of its catalytic activity. PMID: 21385567
    6. MSK1 and MSK2 are differentially regulated by CK2 during the UV response and that MSK2 is the major protein kinase responsible for the UV-induced phosphorylation of p65 at Ser(276) that positively regulates NF-kappaB activity in MDA-MB-231 cells PMID: 19933278
    7. Dimethylfumarate specifically inhibits MSK1 and 2 activations and subsequently inhibits NF-kappaB-induced gene-transcriptions, which are believed to be important in the pathogenesis of psoriasis PMID: 17495961

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 數據庫鏈接：

    HGNC: 10433

    OMIM: 603606

    KEGG: hsa:8986

    STRING: 9606.ENSP00000333896

    UniGene: Hs.105584



主站蜘蛛池模板： 久久婷婷六月综合色液啪| 人人做人人爽人人爱| 国产精品videossex久久发布 | 国产精欧美一区二区三区| 国产精品岛国久久久久| 人人爽人人爽人人片av东京热| 成人无码午夜在线观看| 漂亮人妻被中出中文字幕| 无码国产精成人午夜视频一区二区 | 国产成人vr精品a视频| 新区乱码无人区二精东| 久久综合给合久久狠狠97色| 国产网红无码精品视频| 毛色毛片免费观看| 成人片黄网站a毛片免费观看| 人妻无码中字在线a| 成人免费国产精品视频| www亚洲精品久久久| 欧美人与动牲交欧美精品| 天堂资源中文| 成人亚洲精品久久久久软件| 国产sm调教折磨视频失禁| 色琪琪av中文字幕一区二区| 中文字幕高清免费日韩视频在线 | 精品玖玖玖视频在线观看| 亚洲va天堂va欧美片a在线| 精品人妻伦一二三区久久aaa片| 欧美精品一区二区蜜臀亚洲| 亚洲人成亚洲精品| 久久精品香蕉绿巨人登场| 丰满人妻熟妇乱又仑精品| 18禁黄污吃奶免费看网站| 在线亚洲日产一区二区| 亚洲综合久久无码色噜噜| 精品午夜福利无人区乱码一区| 欧美性猛交xxxx富婆| 免费人成再在线观看视频| 日韩毛片无码永久免费看| 免费观看18禁无遮挡真人网站| 9l国产精品久久久久麻豆| 中文字幕在线日亚洲9|